Results 221 to 230 of about 1,960,778 (332)

MOESM5 of Genome-wide association analysis and accuracy of genome-enabled breeding value predictions for resistance to infectious hematopoietic necrosis virus in a commercial rainbow trout breeding population

, 2019
Roger L. Vallejo, Hao Cheng, Breno Fragomeni, Kristy Shewbridge, Guangtu Gao, John B. MacMillan, Richard Towner, Yniv Palti   +7 more
openalex   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Association prediction of lncRNAs and diseases using multiview graph convolution neural network. [PDF]

Front Genet
Zhang W, Zeng Y, Xiang X, Zhao B, Hu S, Li L, Zhu X, Wang L.   +7 more
europepmc   +1 more source

DAEMDA: A Method with Dual-Channel Attention Encoding for miRNA-Disease Association Prediction. [PDF]

Biomolecules, 2023
Dong B, Sun W, Xu D, Wang G, Zhang T.
europepmc   +1 more source

TREX1, a predator for treating MSI‐H tumors?

Molecular Oncology, EarlyView.
Immunotherapy benefits many patients; yet, some with MSI‐H tumors remain unresponsive despite their high immunogenicity. Xu et al. reveal that TREX1 enables immune evasion by degrading cytosolic DNA and suppressing cGAS–STING–IFN‐I signaling. TREX1 loss restores DNA sensing, increases CD8+ T and NK cell infiltration, and boosts antitumor immunity ...
Elena Benidovskaya, Joséphine Deneft, Marc Van den Eynde   +2 more
wiley   +1 more source

CoupleMDA: Metapath-Induced Structural-Semantic Coupling Network for miRNA-Disease Association Prediction. [PDF]

Int J Mol Sci
Li Z, Chen G, Tan G, Chen CY.
europepmc   +1 more source

Realizing the promise of genome-wide association studies for effector gene prediction

Maria C. Costanzo, Laura W. Harris, Yue Ji, Aoife McMahon, Noël P. Burtt, Jason Flannick   +5 more
openalex   +2 more sources

RKNNMDA: Ranking-based KNN for MiRNA-Disease Association prediction

, 2017
Xing Chen, Qiao-Feng Wu, Guiying Yan
openalex   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

A Novel Drug-Disease Association Prediction Method Based on Deep Non-Negative Matrix Factorization with Local Graph Feature. [PDF]

Interdiscip Sci
Yang M, Yang B, Chen J, Tang X, Duan G.
europepmc   +1 more source