Results 161 to 170 of about 9,278,183 (294)

Lysyl oxidase (LOX)‐mediated remodeling of the extracellular matrix

open access: yesFEBS Letters, EarlyView.
The lysyl oxidase (LOX) family of enzymes drives extracellular matrix remodeling by oxidizing collagen, elastin, and fibronectin, promoting covalent cross‐link formation. This activity regulates tissue architecture and mechanical properties, while its dysregulation contributes to fibrosis, cardiovascular disease, glaucoma, connective tissue disorders ...
Fernando Rodríguez‐Pascual   +3 more
wiley   +1 more source

Incremental maintenance of ontology-exploiting association rules

open access: yes, 2012
[[abstract]]The problem of mining association rules incorporated with domain knowledge (ontology) has attracted lots of researchers’attention recently.
Jeng, Rong   +2 more
core  

Invisible but not inaccessible—Revealing transient oligomers formed by intrinsically disordered proteins with solution NMR and complementary methods

open access: yesFEBS Letters, EarlyView.
Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley   +1 more source

Goal association rule

open access: yes, 2010
碩士傳統的關聯式法則,是對所有的交易進行分析,將所有交易隱含的關聯找出來,在沒有針對特定目標處理的情況下,往往落入兩種困境,一是處理的時間過長,另外則是產生的關聯法則過多。使用傳統的關聯式法則,過程中需要同時處理龐大的非特定目標,再從中取得特定目標的結果,雖然最後也能取得特定目標的關聯,事實上,決策者可能只對及時的、特定目標發生的關聯有濃厚的興趣,例如:行銷人員於新促銷檔期開始後,觀察消費者對促銷型錄產品購買的行為,以預期銷售額能否達成營業目標。資訊的時效性與準確性,在選擇處理的方式時就已經決定 ...
張瑜紋; Chang, Yu-wen
core  

Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research

open access: yesFEBS Letters, EarlyView.
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

open access: yesMolecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce   +11 more
wiley   +1 more source

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