Results 51 to 60 of about 89,998 (265)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Scalable multi-metric association rule learning for explainable book recommendations

Frontiers in Computer Science
Digital reading platforms have grown rapidly, increasing information overload and highlighting the need for efficient and transparent recommendation systems.
Adel Hidri, Suleiman Ali AlSaif, Eman AlShehri, Minyar Sassi Hidri   +3 more
doaj   +1 more source

Synthesizing configuration file specifications with association rule learning [PDF]

Proceedings of the ACM on Programming Languages, 2017
System failures resulting from configuration errors are one of the major reasons for the compromised reliability of today's software systems. Although many techniques have been proposed for configuration error detection, these approaches can generally only be applied after an error has occurred.
Mark Santolucito, Ennan Zhai, Rahul Dhodapkar, Aaron Shim, Ruzica Piskac   +4 more
openaire   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Learning Weighted Association Rules in Human Phenotype Ontology [PDF]

, 2020
The Human Phenotype Ontology (HPO) is a structured repository of concepts (HPO Terms) that are associated to one or more diseases. The process of association is referred to as annotation. The relevance and the specificity of both HPO terms and annotations are evaluated by a measure defined as Information Content (IC).
Giuseppe Agapito, Mario Cannataro, Pietro H. Guzzi, Marianna Milano   +3 more
openaire   +2 more sources

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Exploring the Suitability of Rule-Based Classification to Provide Interpretability in Outcome-Based Process Predictive Monitoring

Algorithms, 2022
The development of models for process outcome prediction using event logs has evolved in the literature with a clear focus on performance improvement. In this paper, we take a different perspective, focusing on obtaining interpretable predictive models ...
Suhwan Lee, Marco Comuzzi, Nahyun Kwon
doaj   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

NiaAutoARM: Automated Framework for Constructing and Evaluating Association Rule Mining Pipelines

Mathematics
Numerical Association Rule Mining (NARM), which simultaneously handles both numerical and categorical attributes, is a powerful approach for uncovering meaningful associations in heterogeneous datasets.
Uroš Mlakar, Iztok Fister, Iztok Fister
doaj   +1 more source