Results 151 to 160 of about 124,825 (308)

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

open access: yesFEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

REFRAMING THE SKILLED WORKER: THE PSYCHOLOGICAL AND INSTITUTIONAL ORIGINS OF THE GERMAN SKILLS MACHINE

open access: yesEssays in Economic and Business History, 2005
In 1926, shortly after the German economy had emerged from the fog of post-World War I hyperinflation, the principle employers’ groups, the National Association of German Industry and the Association of German Employers’ Organizations, founded a Working ...
David Meskill
doaj   +2 more sources

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

open access: yesFEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara   +3 more
wiley   +1 more source

Measuring the performance of equity-share schemes in South African agriculture: A focus on financial criteria

open access: yes
This study aims to develop a robust methodology for measuring financial performance of equity-share schemes. Several studies have investigated various aspects of performance of these schemes but no single study has yet measured their performance using an
Ferrer, Stuart R.D.   +2 more
core  

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

open access: yesFEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee   +7 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

On Generalized Semidirect Product of Association Schemes

open access: yes, 2003
In this paper, we introduce a new product operation of association schemes in order to generalize the notion of semidirect products and wreath product. We then show that our construction covers some association schemes which are neither wreath products ...
Sejeong Bang
core  

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Eigenspace embeddings of imprimitive association schemes

open access: yes
For a given symmetric association scheme $mathcal{A}$ and its eigenspace $S_j$ there exists a mapping of vertices of $mathcal{A}$ to unit vectors of $S_j$, known as the spherical representation of $mathcal{A}$ in $S_j$, such that the inner products of ...
Vidali, Janoš
core   +1 more source

Application of association rules and simulated annealing algorithms in optimizing traditional Chinese medicine placement schemes

open access: yesBMC Health Services Research
Background and aim China has used traditional Chinese medicine (TCM) to treat diseases for more than 2000 years. Traditionally, TCMs in medicine cabinets are arranged alphabetically or on the basis of experience, but this arrangement greatly affects ...
Fu-Xian Zou   +6 more
doaj   +1 more source

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