Results 71 to 80 of about 110,863 (301)

Dynamical Ion Association and Transport Properties in PEO–LiTFSI Electrolytes: Effect of Salt Concentration

, 2022
The association of ions describes the formation of ion species in electrolyte solutions and is strongly related to the salt concentration. However, the discussion of ion species and their transport is ambiguous in some studies on electrolyte materials ...
Jinle Lan (2135185), Gang Sui (2946174), Peibin Kang (12421715), Yaotian Su (8668038), Yanyan Zhu (32035), Dongli Chen (2988357), Xiaoping Yang (460478), Lingyun Wu (144811)   +7 more
core   +1 more source

Unraveling the intercellular communication disruption and key pathways in Alzheimer’s disease: an integrative study of single-nucleus transcriptomes and genetic association

Alzheimer’s Research & Therapy
Background Recently, single-nucleus RNA-seq (snRNA-seq) analyses have revealed important cellular and functional features of Alzheimer's disease (AD), a prevalent neurodegenerative disease.
Andi Liu, Brisa S. Fernandes, Citu Citu, Zhongming Zhao   +3 more
doaj   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

ESR Line-width Alternation and Na+ Transfer in the Ion Pairs of 3,5-Dinitropyridine

, 1978
An ESR study of the ion pairs of 3,5-dinitropyridine with alkali metals in tetrahydrofuran and 1,2-dimethoxyethane is reported. The analysis of the ESR spectra of the ion pair with Na+ after the addition of sodium tetraphenylborate shows an ...
C.Oliva, G. Morosi, P. Cremaschi, A. Gamba, M. Barzaghi, M. Simonetta   +5 more
core   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Kinetics and equilibria of ion-molecule association reactions : studied using temperature variable high pressure ion sources [PDF]

Interest in termolecular association reactions of the type shown below, stems from their importance in the chemistry of planetary atmospheres, gas-cooled nuclear reactors and gas-phase cluster ions.
Gallagher, Richard Thomas
core  

Use of Genome-Wide Expression Data to Mine the "Gray Zone" of GWA Studies Leads to Novel Candidate Obesity Genes [PDF]

, 2009
To get beyond the “low-hanging fruits” so far identified by genome-wide association (GWA) studies, new methods must be developed in order to discover the numerous remaining genes that estimates of heritability indicate should be contributing to complex ...
Wichmann, Heinz-Erich, Cornelia M van Duijn, Wichmann, H. -Erich, Duijn, C.M. (Cornelia) van, Ripatti, S, Taskinen, MR, Hannele Yki-Järvinen, Veikko Salomaa, Surakka, I. (Ida), Salomaa, V. (Veikko), van Duijn, Cornelia M., Pietilainen, K.H., Naukkarinen, J., Surakka, I., Surakka, I, Kaprio Jaakko, Salomaa, Veikko, Yki-Järvinen Hannele, Marja-Riitta Taskinen, H.-Erich Wichmann, Wichmann, H.-E., Taskinen, M. (Marja Riitta), Rissanen, A., Yki-Jarvinen, H., Peltonen, L. (Leena Johanna), Ida Surakka, Jaakko Kaprio, van Duijn, C.M., Surakka Ida, Boomsma, D.I., Peltonen, L, Naukkarinen, Jussi, Duijn, C.M. van, Salomaa, V, Peltonen, L., Wichmann H.-Erich, null null, Rissanen, Aila, Kaprio, Jaakko, Jussi Naukkarinen, Peltonen, Leena, Salomaa, V., Taskinen Marja-Riitta, Duijn, Cornelia, Pietilainen, KH, Ripatti, S. (Samuli), Wichmann, HE, Kirsi H. Pietiläinen, ENGAGE Consortium, Salomaa Veikko, Pietiläinen Kirsi H., Taskinen, M.R., Ripatti, S., H-Erich Wichmann, Taskinen, Marja-Riitta, Rissanen, A, Rissanen Aila, Wichmann, H.E., Aila Rissanen, Leena Peltonen, Wichmann, H.E. (Heinz Erich), van Duijn Cornelia M., Naukkarinen, J, Rissanen, A. (Aila), Naukkarinen Jussi, Kaprio, J, Kaprio, J. (Jaakko), Ripatti, Samuli, Yki-Jarvinen, H. (Hannele), Kaprio, J., Kirsi H Pietiläinen, Cornelia M. van Duijn, Ripatti Samuli, Peltonen Leena, Pietiläinen, Kirsi H., Yki-Järvinen, Hannele, Boomsma, D.I.; id_orcid, Pietilainen, K.H. (Kirsi Hannele), Surakka, Ida, Samuli Ripatti, Naukkarinen, J. (Jussi), Yki-Jarvinen, H, Wichmann, H.-Erich   +82 more
core   +1 more source

Periodic Influences on the Charge‐Transfer and Radical Ion Pair Formation in Pnictogen‐Based Frustrated Lewis Pairs

ChemistryEurope
Frustrated Lewis pairs (FLPs) can undergo single‐electron transfer (SET) via photoexcitation of an intermolecular charge–transfer (CT) band, thereby generating highly reactive radical ion pairs (RIPs) with the potential for homolytic CH bond activation.
Lars J. C. van der Zee, Sven C. O. Dik, Joost M. van Gaalen, Demi D. Snabilié, Kevin Dollberg, Carsten von Hänisch, Andreas W. Ehlers, Albert M. Brouwer, J. Chris Slootweg   +8 more
doaj   +1 more source

Supporting the Concept of Genetic Predisposition to Prolonged Recovery Following a Concussion

Orthopaedic Journal of Sports Medicine, 2014
Objectives: During a concussion, mechanical forces cause neuron cell strain that initiates dysfunction through the indiscriminate movement of ions through protein channels.
Jane McDevitt PhD, Ryan Tierney PhD, Jacqueline Phillips MS, John Gaughan PhD, Joseph S. Torg MD, Evgeny Krynetskiy PhD   +5 more
doaj   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source