Results 91 to 100 of about 3,347 (305)

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

open access: yesFEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe   +3 more
wiley   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

(,)- Strongly Derivations Pairs on Rings

open access: yesIbn Al-Haitham Journal for Pure and Applied Sciences, 2016
        Let R be an associative ring. In this paper we present the definition of (s,t)- Strongly derivation pair and Jordan (s,t)- strongly derivation pair on a ring R, and study the relation between them.
I. A. Saed
doaj  

Uniformly Primal Submodule over Noncommutative Ring

open access: yesJournal of Mathematics, 2020
Let R be an associative ring with identity and M be a unitary right R-module. A submodule N of M is called a uniformly primal submodule provided that the subset B of R is uniformly not right prime to N, if there exists an element s∈M−N with sRB⊆N.The set
Lamis J. M. Abulebda
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

open access: yesFEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy   +4 more
wiley   +1 more source

Sheaves on Local Ringed Spaces Associated to Hilbert Rings

open access: yesTokyo Journal of Mathematics, 2001
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
SEKIGUCHI, Koji   +2 more
openaire   +2 more sources

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

The associated graded ring and the index of a Gorenstein local ring [PDF]

open access: yesProceedings of the American Mathematical Society, 1994
Let ( R , m ,
openaire   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Smarandache Non-Associative (SNA-) rings

open access: yes, 2008
this paper we introduce the concept of Smarandache non-associative rings, which we shortly denote as SNA-rings as derived from the general definition of a Smarandache Structure (i.e., a set A embedded with a week structure W such that a proper subset B ...
W.B. Vasantha Kandasamy
core  

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