Results 101 to 110 of about 40,225 (280)
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Generalizing Semi-n-Potent Rings
Қарағанды университетінің хабаршысы. Математика сериясыThe present article deals with the problem of characterizing a widely large class of associative and possibly non-commutative rings. So, we define and explore the class of rings R for which each element in R is a sum of a tripotent element from R and an
A. Javan, A. Moussavi, P. Danchev
doaj +1 more source
A Comparison of Deformations and Geometric Study of Varieties of Associative Algebras
International Journal of Mathematics and Mathematical Sciences, 2007 The aim of this paper is to give an overview and to compare the different deformation theories of algebraic structures. In each case we describe the corresponding notions of degeneration and rigidity.
Abdenacer Makhlouf
doaj +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Full Classification of Finite Singleton Local Rings
AxiomsThe main objective of this article is to classify all finite singleton local rings, which are associative rings characterized by a unique maximal ideal and a distinguished basis consisting of a single element.
Sami Alabiad, Yousef Alkhamees
doaj +1 more source
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
AAA+ protein unfoldases—the Moirai of the proteome
FEBS Letters, EarlyView.AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley +1 more source
GARDNER PROBLEM REVISITED: FURTHER PROPERTIES OF INDAH RADICAL
BarekengRadical theory arises naturally from the study of non-commutative rings and plays a central role in the structural analysis of ring classes. Among the radical classes that have received considerable attention are the prime radical β and the IndaH ...
Puguh Wahyu Prasetyo +1 more
doaj +1 more source