Results 111 to 120 of about 56,095 (266)

A randomized concave programming method for choice network revenue management [PDF]

open access: yes
Models incorporating more realistic models of customer behavior, as customers choosing from an offer set, have recently become popular in assortment optimization and revenue management. The dynamic program for these models is intractable and approximated
Kalyan Talluri
core  

Management of assortment policy of the enterprise [PDF]

open access: yes, 2015
Проведено систематизацію визначень «асортиментна політика». Запропоновано класифікацію підходів до визначення сутності асортиментної політики. Розроблено концепцію управління асортиментною політикою підприємства.Authors are systematized the definitions ...
Савельєв, Денис Сергійович   +1 more
core  

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

open access: yesFEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil   +4 more
wiley   +1 more source

Explaining consumers' reactions to assortment size [PDF]

open access: yes, 2007
In this thesis we propose that the impact of assortment size on choice is moderated by goals (regulatory focus). We argue that if the choice is approached with a prevention focus, a consumer who lacks articulated preferences will concentrate on avoiding ...
Matyas, Lissa
core  

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

open access: yesFEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Assortment Variety: Attribute versus Product-Based

open access: yes
Retailers need to decide on the content and structure of their product assortments, and thereby on the degree of variety that they offer to their customers.This paper compares measures of assortment variety and relates them to underlying variety ...
Herpen, H.W.I. van, Pieters, R.
core  

How Assortment Variety Affects Assortment Attractiveness: A Consumer Perspective [PDF]

open access: yes, 2006
Variëteit is overal aanwezig. Telkens weer moeten mensen kiezen uit een enorme hoeveelheid mogelijkheden. Waarderen consumenten zoveel variëteit eigenlijk wel in al de keuzes die ze moeten maken?
Vries-van Ketel, E. de
core  

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

open access: yesFEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

open access: yesFEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

open access: yesFEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson   +6 more
wiley   +1 more source

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