Results 121 to 130 of about 1,451,332 (395)

Increased Levels of Airway Neutrophils Reduces the Inhibitory Effects of Inhaled Glucocorticosteroids on Allergen-Induced Airway Eosinophils

Canadian Respiratory Journal, 2002
BACKGROUND: Treatment with inhaled glucocorticosteroids attenuates allergen-induced airway inflammation but is less effective in people with asthma who have noneosinophilic airway inflammation.
Gail M Gauvreau, Mark D Inman, Margaret Kelly, Richard M Watson, Sandra C Dorman, Paul M O’Byrne   +5 more
doaj   +1 more source

Identification of asthma phenotypes using cluster analysis in the Severe Asthma Research Program.

American Journal of Respiratory and Critical Care Medicine, 2010
RATIONALE The Severe Asthma Research Program cohort includes subjects with persistent asthma who have undergone detailed phenotypic characterization. Previous univariate methods compared features of mild, moderate, and severe asthma.
W. Moore, D. Meyers, S. Wenzel, W. G. Teague, Huashi Li, Xingnan Li, R. D'Agostino, M. Castro, D. Curran-Everett, Anne M. Fitzpatrick, B. Gaston, N. Jarjour, R. Sorkness, William J. Calhoun, K. Chung, S. Comhair, R. Dweik, E. Israel, Stephen P. Peters, William W. Busse, S. Erzurum, E. Bleecker   +21 more
semanticscholar   +1 more source

Asthma in the Elderly

Clinics in Geriatric Medicine, 2003
The older population has seen the greatest increase in the prevalence of current asthma in recent years. Asthma may begin at any age and when it occurs at an advanced as opposed to a young age, it is often nonatopic, severe, and unremitting. Unfortunately, geriatric-specific guidelines are not available for the diagnosis and treatment of asthma ...
openaire   +5 more sources

ER‐phagy Activation by AMFR Attenuates Cardiac Fibrosis Post‐Myocardial Infarction via mTORC1 Pathway

Advanced Science, EarlyView.
By catalyzing FAM134B ubiquitination and activating ER‐phagy, AMFR alleviates progressive fibrosis and cardiac dysfunction by inhibiting the mTORC1 pathway. Consequently, these findings underscore the essential role of AMFR‐driven ER‐phagy in mitigating the progression of fibrotic responses, offering a potential therapeutic target for preventing heart ...
Zhixiang Wang, Kaifan Niu, Wei Liu, Xinyun Wang, Boshen Yang, Taixi Li, Yizhi Chen, Yuanyuan Jin, Yu Chen, Yangyi Lin, Xian Jin   +10 more
wiley   +1 more source

The impact of modifiable risk factor reduction on childhood asthma development

Clinical and Translational Medicine, 2018
Childhood asthma is responsible for significant morbidity and health care expenditures in the United States. The incidence of asthma is greatest in early childhood, and the prevalence is projected to continue rising in the absence of prevention and ...
Andrew Abreo, Tebeb Gebretsadik, Cosby A. Stone, Tina V. Hartert   +3 more
doaj   +1 more source

Environmental public health tracking of childhood asthma using California health interview survey, traffic, and outdoor air pollution data. [PDF]

, 2008
BackgroundDespite extensive evidence that air pollution affects childhood asthma, state-level and national-level tracking of asthma outcomes in relation to air pollution is limited.ObjectivesOur goals were to evaluate the feasibility of linking the 2001 ...
Balmes, John, English, Paul, Meng, Ying-Ying, Ritz, Beate, Rull, Rudolph P, Wilhelm, Michelle   +5 more
core  

Oral glucocorticoid-sparing effect of mepolizumab in eosinophilic asthma.

New England Journal of Medicine, 2014
BACKGROUND Many patients with severe asthma require regular treatment with oral glucocorticoids despite the use of high-dose inhaled therapy. However, the regular use of systemic glucocorticoids can result in serious and often irreversible adverse ...
E. Bel, S. Wenzel, P. Thompson, C. Prazma, O. Keene, S. Yancey, H. Ortega, I. Pavord   +7 more
semanticscholar   +1 more source

Developing Biomaterial‐Based mRNA Delivery System for Lung Disease Treatment

Advanced Science, EarlyView.
Schematic illustration of biomaterial delivery mRNA for the treatment of lung diseases. Abstract Lung disease remains a persistent global health challenge. Advances in medical research have led to innovative strategies to combat these conditions, with biomaterials emerging as a promising platform for targeted drug delivery.
Qiancheng Gu, Huaqian Xue, Zhiyun Liu, Jiameng Rao, Lingyao Zeng, Chen Zhang, Lanjie Lei, Liyun Shi   +7 more
wiley   +1 more source

Identifying barriers and facilitators to improving prehospital care of asthma: views of ambulance clinicians [PDF]

, 2010
Background: In 2008/09 there were nearly 80,000 emergency hospital admissions for asthma. Current UK guidelines emphasise the importance of evidence-based prehospital assessment and treatment of asthma for improving patient outcomes and reducing ...
Knowles, Stacey, Shaw, Deborah, Siriwardena, A. Niroshan   +2 more
core  

Cumulative Impact of Environmental Pollution and Population Vulnerability on Pediatric Asthma Hospitalizations: A Multilevel Analysis of CalEnviroScreen. [PDF]

, 2019
The CalEnviroScreen created by the Office of Environmental Health Hazard Assessment, Sacramento, USA, is a place-based dataset developed to measure environmental and social indicators that are theorized to have cumulative health impacts on populations ...
Alcala, Emanuel, Brown, Paul, Capitman, John A, Cisneros, Ricardo, Gonzalez, Mariaelena   +4 more
core   +1 more source