Results 141 to 150 of about 1,451,332 (395)

The parasitic worm-derived immunomodulator, ES-62 and its drug-like small molecule analogues exhibit therapeutic potential in a model of chronic asthma [PDF]

open access: yes, 2016
Chronic asthma is associated with persistent lung inflammation and long-term remodelling of the airways that have proved refractory to conventional treatments such as steroids, despite their efficacy in controlling acute airway contraction and bronchial ...
Al-Riyami, L.   +6 more
core   +1 more source

Eosinophilic inflammation in asthma.

open access: yesNew England Journal of Medicine, 1990
BACKGROUND AND METHODS The importance of eosinophils in the pathogenesis of bronchial asthma is not established. In an attempt to evaluate the role of eosinophilic inflammation in asthma, we compared 10 normal subjects with 43 patients with chronic ...
J. Bousquet   +10 more
semanticscholar   +1 more source

R‐APEX: A Knowledge Graph–Based Platform for the Elucidation of the Toxicological Mechanisms of Ambient Particulate Matter

open access: yesAdvanced Intelligent Systems, EarlyView.
R‐APEX is a knowledge graph platform developed to investigate how air pollutants such as particularly fine particulate matter (PM2.5) affect human health. By integrating large‐scale biomedical data and using machine learning, it reveals pollutant–gene–disease associations.
Zhixing Zhu   +7 more
wiley   +1 more source

Asthma [PDF]

open access: yesPostgraduate Medical Journal, 1996
AbstractBronchial asthma is now recognised to be a major cause of morbidity and even mortality in people of all ages. Two important ideas have changed our approach to asthma management. The first is understanding that asthma is a chronic inflammatory disorder which needs regular treatment with anti-inflammatory drugs such as inhaled corticosteroids to ...
openaire   +2 more sources

Autonomous Recognition of Retained Secretions in Central‐Airway Based on Deep Learning for Adult Patients Receiving Invasive Mechanical Ventilation

open access: yesAdvanced Intelligent Systems, EarlyView.
This work presents a deep learning model to autonomously recognize and classify the secretion retention into three levels for patients receiving invasive mechanical ventilation, achieving 89.08% accuracy. This model can be implemented to ventilators by edge computing, whose feasibility is approved.
Shuai Wang   +6 more
wiley   +1 more source

Clinical Models to Compare the Safety and Efficacy of Inhaled Corticosteroids in Patients with Asthma

open access: yesCanadian Respiratory Journal, 2003
There is no consensus on the methods to compare the clinical efficacy of different inhaled corticosteroids. A comparison needs to be made in terms of relative potency, and studies should include two-, or preferably, three-dose comparisons.
Krishnan Parameswaran   +6 more
doaj   +1 more source

Allergens, germs and asthma [PDF]

open access: yes, 2015
Objective To explore asthma pathogenesis using data from upper and lower airways. Data Source English-language papers on human asthma and nasal polyp subjects from 1990 onwards.
Scadding, GK
core  

Harnessing halophyte‐derived allelochemicals and signaling molecules to enhance salinity tolerance in crops

open access: yesAmerican Journal of Botany, EarlyView.
Abstract Premise Soil salinization is a growing global challenge that significantly reduces agricultural productivity by impairing seed germination, growth, and yield. While conventional crops have limited tolerance to high salinity, halophytes are promising biological models for developing strategies to sustain agriculture in saline environments and ...
Gyöngyi Székely, Csengele Barta
wiley   +1 more source

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