Results 141 to 150 of about 887,968 (372)

Clinical Relevance of Drug–Drug Interactions With Antibiotics as Listed in a National Medication Formulary: Results From Two Large Population‐Based Case‐Control Studies in Patients Aged 65–100 Years Using Linked English Primary Care and Hospital Data

Clinical Pharmacology &Therapeutics, Volume 113, Issue 2, Page 423-434, February 2023., 2023
This study evaluated drug–drug interactions (DDIs) between antibiotic and nonantibiotic drugs listed with warnings of severe outcomes in the British National Formulary based on adverse drug reaction (ADR) detectable with routine International Classification of Diseases, Tenth Revision coding.
Tjeerd Pieter van Staa, Munir Pirmohamed, Anita Sharma, Iain Buchan, Darren M. Ashcroft   +4 more
wiley   +1 more source

Synthesis and Characterization of Photoswitchable Covalent Ligands for the β2‐Adrenoceptor

Angewandte Chemie, EarlyView.
A structure‐based design of a covalent photoswitchable ligand for the β2‐adrenergic receptor, a therapeutically relevant GPCR, is described. This tool facilitates the modification of the intrinsic activity of the protein by light. Computational analysis of its mechanism of action suggests that the photoswitch takes place within the binding pocket ...
Ulrike Wirth, Eduard Neu, Davide Provasi, Steffen Feustel, Maximilian F. Schmidt, Harald Hübner, Dorothée Weikert, Marta Filizola, Burkhard König, Peter Gmeiner   +9 more
wiley   +2 more sources

A Comprehensive Study on the Applications of Machine Learning for the Medical Diagnosis and Prognosis of Asthma [PDF]

arXiv, 2018
An estimated 300 million people worldwide suffer from asthma, and this number is expected to increase to 400 million by 2025. Approximately 250,000 people die prematurely each year from asthma out of which, almost all deaths are avoidable. Most of these deaths occur because the patients are unaware of their asthmatic morbidity.
arxiv  

Persistent Eosinophilic Inflammation Is Not a Feature of Type 2 CRS Patients Failing Anti‐IL‐5R Therapy and Requiring Class Switching to Anti‐IL‐4/13

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Type 2 inflammation dominates eosinophilic chronic rhinosinusitis (eCRS) and adult onset asthma. IL‐4, ‐5, and ‐13 are prominent disease mediators. Disease control can be achieved with biologic therapies. However, despite some patients entering remission, others experience poor control. Aim We aimed to describe eCRS patients treated
Peta‐Lee Sacks, Christian M Meerwein, Peter Earls, Cedric Thiel, Christine Choy, Raewyn G Campbell, Raymond Sacks, Larry Kalish, Richard J Harvey   +8 more
wiley   +1 more source

Obesity and asthma

Archives of Disease in Childhood, 2019
2 ) into quintiles and evaluated the relationship between BMI quintile and self-reported asthma, degree of airflow limitation and rescue bronchodilator use. In their analysis, individuals in the highest BMI quintile had the greatest odds of self-reported
D. Homnick
semanticscholar   +1 more source

Walkie talkies to aid health care workers’ compliance with personal protective equipment in the fight against COVID-19

Critical Care, 2020
Dominic Fenn, Jonny Coppel, Jessica Kearney, Lucy Everson, Simon Braithwaite, Rahul Chodhari   +5 more
doaj   +1 more source

Airway wall splice quantitative trait locus analysis reveals novel downstream mechanisms for known asthma single-nucleotide polymorphisms

ERJ Open Research, 2023
Tessa M. Kole, Simon D. Pouwels, Rene Bults, Marlies E. Ketelaar, Victor Guryev, Lisanne Koll, Huib A.M. Kerstjens, Martijn C. Nawijn, Alen Faiz, Maarten van den Berge   +9 more
doaj   +1 more source

Clinical Models to Compare the Safety and Efficacy of Inhaled Corticosteroids in Patients with Asthma

Canadian Respiratory Journal, 2003
There is no consensus on the methods to compare the clinical efficacy of different inhaled corticosteroids. A comparison needs to be made in terms of relative potency, and studies should include two-, or preferably, three-dose comparisons.
Krishnan Parameswaran, Richard Leigh, Paul M O'Byrne, Margaret M Kelly, Charlie H Goldsmith, Frederick E Hargreave, Myrna Dolovich   +6 more
doaj   +1 more source

Über die Beziehungen der Bronchitis fibrinosa oder mucinosa plastica und des Asthmas zur chronischen Lungentuberkulose [PDF]

, 1920
Georg Schröder
openalex   +1 more source

Mucus plugs in patients with asthma linked to eosinophilia and airflow obstruction

Journal of Clinical Investigation, 2018
BACKGROUND. The link between mucus plugs and airflow obstruction has not been established in chronic severe asthma, and the role of eosinophils and their products in mucus plug formation is unknown. METHODS.
E. Dunican, B. Elicker, D. Gierada, S. Nagle, M. Schiebler, J. Newell, W. Raymond, M. Lachowicz-Scroggins, S. Di Maio, E. Hoffman, M. Castro, S. Fain, N. Jarjour, E. Israel, B. Levy, S. Erzurum, S. Wenzel, D. Meyers, E. Bleecker, B. Phillips, D. Mauger, Erin D. Gordon, P. Woodruff, M. Peters, J. Fahy   +24 more
semanticscholar   +1 more source