Results 51 to 60 of about 34,554 (299)

Immune Cell Dysregulation in Hindlimb Unloading Mouse Model: Implications for Space Applications [PDF]

Journal of Biomedical Physics and Engineering
Background: Hindlimb unloading (HU) mice is a ground-based model that simulates the effects of microgravity. Since microgravity significantly affects the immune system, understanding immune cell function under these conditions is crucial for developing ...
Sadegh Masoudi, Mehdi Kalani, Ali Alavianmehr, Mohammad Amin Mosleh-Shirazi, Seyed Mohammad Javad Mortazavi, Shirin Farjadian   +5 more
doaj   +1 more source

The transcriptome response of astronaut leukocytes to long missions aboard the International Space Station reveals immune modulation

Frontiers in Immunology, 2023
IntroductionSpaceflight leads to the deconditioning of multiple body systems including the immune system. We sought to characterize the molecular response involved by capturing changes in leukocyte transcriptomes from astronauts transitioning to and from
Daniel Stratis, Guy Trudel, Guy Trudel, Guy Trudel, Lynda Rocheleau, Martin Pelchat, Odette Laneuville, Odette Laneuville   +7 more
doaj   +1 more source

Stability of Medicinal Nanoemulsions to Spaceflight: Insights From the StarMed Experiment

Advanced Healthcare Materials, EarlyView.
Chitosan‐coated melatonin nanoemulsions (MN) recovered from a sounding rocket mission preserve droplet size and controlled‐release behavior, whereas uncoated nanoemulsions show ageing‐driven droplet growth and increased accessible drug fraction. Simple polymer coatings thus enhance the flight resilience of liquid space medicines under cumulative launch
Modupe Adebowale, Nguyen Van Duc Long, Philip M. Williams, Jens Hauslage, Volker Hessel   +4 more
wiley   +1 more source

Modulation of neutrophil-to-lymphocyte ratio and gut microbiome balance in astronauts: potential benefits of novel beta-glucans during space missions

Frontiers in Immunology
Senthilkumar Preethy, Rajappa Senthilkumar   +1 more
exaly   +3 more sources

Multi-omic, Single-Cell, and Biochemical Profiles of Astronauts Guide Pharmacological Strategies for Returning to Gravity

Cell Reports, 2020
SUMMARY The National Aeronautics and Space Administration (NASA) Twins Study created an integrative molecular profile of an astronaut during NASA’s first 1-year mission on the International Space Station (ISS) and included comparisons to an identical ...
Monica Gertz, Christopher R. Chin, Delia Tomoiaga, M. Mackay, Christina L. Chang, D. Butler, Ebrahim Afshinnekoo, D. Bezdan, Michael A. Schmidt, C. Mozsary, A. Melnick, Francine E. Garrett-Bakelman, B. Crucian, S. M. Lee, S. Zwart, Scott M Smith, Cem Meydan, C. Mason   +17 more
semanticscholar   +1 more source

Photocatalytic Water Splitting on the Lunar Surface: Prospects for In Situ Resource Utilization

Advanced Materials Interfaces, EarlyView.
Water has been found in craters on the moon nearby locations which are illuminated >80% of the time. Photocatalysis uses energy from sunlight to drive chemical reactions such as water splitting to produce oxygen and hydrogen. It is a scalable technology that requires lighter equipment and utilizes resources available on the moon. ABSTRACT The discovery
Ranjani Kalyan, Thomas D. Small, Gregory F. Metha, Mahmoud Adel Hamza, Thomas J. O'Dea, Yideng Shen, Cameron J. Shearer   +6 more
wiley   +1 more source

Factors affecting flavor perception in space: Does the spacecraft environment influence food intake by astronauts?

Comprehensive Reviews in Food Science and Food Safety, 2020
The intention to send a crewed mission to Mars involves a huge amount of planning to ensure a safe and successful mission. Providing adequate amounts of food for the crew is a major task, but 20 years of feeding astronauts on the International Space ...
A. J. Taylor, J. Beauchamp, L. Briand, M. Heer, T. Hummel, C. Margot, S. McGrane, S. Pieters, P. Pittia, C. Spence   +9 more
semanticscholar   +1 more source

A Cryopreservation‐Based Supply Chain Strategy for Extrusion Bioprinting in Space

Advanced Materials Technologies, EarlyView.
Extrusion bioprinting on crewed space platforms requires a bioink that stays functional along the logistic chain. Here, cells and biomaterial ink travel separately, the cells cryopreserved and the ink cold stored, and are combined only minutes before printing.
Johannes Windisch, Max von Witzleben, Richard Frank Richter, Finn Dani, Constantin Greil, Sarah Duin, Anja Lode, Michael Gelinsky   +7 more
wiley   +1 more source

Optical Metabolic Imaging of Human Skin Using Multiphoton FLIM Tomography

IEEE Photonics Journal
Optical metabolic imaging (OMI) of human skin is based on the cellular autofluorescence, mainly due to two-photon excitation of fluorescent coenzymes such as NAD(P)H (reduced nicotinamide adenine dinucleotide) and FAD (flavin adenine dinucleotide), with ...
K. Koenig
doaj   +1 more source

Expedition Cognition: A Review and Prospective of Subterranean Neuroscience With Spaceflight Applications

Frontiers in Human Neuroscience, 2018
Renewed interest in human space exploration has highlighted the gaps in knowledge needed for successful long-duration missions outside low-Earth orbit.
Nicolette B. Mogilever, Lucrezia Zuccarelli, Ford Burles, Giuseppe Iaria, Giacomo Strapazzon, Loredana Bessone, Emily B. J. Coffey   +6 more
doaj   +1 more source