Results 1 to 10 of about 276,741 (208)
Space Radiation Biology for “Living in Space” [PDF]
BioMed Research International, 2020 Space travel has advanced significantly over the last six decades with astronauts spending up to 6 months at the International Space Station. Nonetheless, the living environment while in outer space is extremely challenging to astronauts. In particular, exposure to space radiation represents a serious potential long‐term threat to the health of ...
Satoshi Furukawa +21 more
europepmc +4 more sources
MicroRNAs Responding to Space Radiation [PDF]
International Journal of Molecular Sciences, 2020 High-energy and high-atom-number (HZE) space radiation poses an inevitable potential threat to astronauts on deep space exploration missions. Compared with low-LET radiation, high-energy and high-LET radiation in space is more efficient in inducing clustered DNA damage with more serious biological consequences, such as carcinogenesis, central nervous ...
Yujie Yan +3 more
openaire +3 more sources
Carcinogenesis induced by space radiation: A systematic review [PDF]
Neoplasia, 2022 Guangming Zhou, Wentao Hu
exaly +2 more sources
Radiation protection in space [PDF]
Acta Astronautica, 1995 Radiation environment, basic concepts of radiation protection, and specific aspects of the space radiation field are reviewed. The discussion of physico-chemical and subcellular radiation effects includes mechanisms of radiation action and cellular consequences.
Reitz, G., Facius, R., Sandler, H. (1)
openaire +5 more sources
Recent Advances and Challenges in Polymer-Based Materials for Space Radiation Shielding [PDF]
PolymersElisa Toto +2 more
exaly +2 more sources
Electromagnetic dissociation and space radiation [PDF]
Acta Astronautica, 2007 Relativistic nucleus-nucleus reactions occur mainly through the Strong or Electromagnetic (EM) interactions. Transport codes often neglect the latter. This work shows the importance of including EM interactions for space radiation applications.
Norbury, John W., Maung, Khin Maung
openaire +2 more sources
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source