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Long-term space missions’ effects on the human organism: what we do know and what requires further research

Frontiers in Physiology
Space has always fascinated people. Many years have passed since the first spaceflight, and in addition to the enormous technological progress, the level of understanding of human physiology in space is also increasing.
Marcin Tomsia, Julia Cieśla, Joanna Śmieszek, Szymon Florek, Agata Macionga, Katarzyna Michalczyk, Dominika Stygar, Dominika Stygar   +7 more
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Microgravity‐induced changes in skeletal muscle and possible countermeasures: What we can learn from bed rest and human space studies

Experimental Physiology
Despite exercise countermeasures to sustain health and performance in spaceflight, complete maintenance of muscle mass and functions in microgravity is still not possible for most astronauts.
Alessandra Bosutti, Bergita Ganse, Nicola A. Maffiuletti, Rob C. I. Wüst, Gustav J. Strijkers, Andy Sanderson, Hans Degens   +6 more
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The Biological Overview Effect: Our Place in Nature

Journal of Big History, 2019
While gazing at the Earth from orbit, some astronauts have described a cognitive shift known as the overview effect. Here we describe an analogous biological overview effect produced by looking at the tiny twig of humanity on the tree of life.
Charles H. Lineweaver, Aditya Chopra
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The Role of Mechanical Stimulation in Recovery of Bone Loss—High versus Low Magnitude and Frequency of Force

Life, 2014
Musculoskeletal pathologies associated with decreased bone mass, including osteoporosis and disuse-induced bone loss, affect millions of Americans annually.
Mamta Patel Nagaraja, Hanjoong Jo
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Microgravity and Cardiovascular Health in Astronauts: A Narrative Review

Health Science Reports
Background Space exploration has become a major interest for scientific and medical research. With increasing duration and frequency of manned space missions, it is crucial to understand the impact of microgravity on the cardiovascular health of ...
John Azariah, Umberto Terranova
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Cognitive performance in ISS astronauts on 6-month low earth orbit missions

Frontiers in Physiology
IntroductionCurrent and future astronauts will endure prolonged exposure to spaceflight hazards and environmental stressors that could compromise cognitive functioning, yet cognitive performance in current missions to the International Space Station ...
Sheena I. Dev, Alaa M. Khader, Sydney R. Begerowski, Steven R. Anderson, Gilles Clément, Suzanne T. Bell   +5 more
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Redefining space pharmacology: bridging knowledge gaps in drug efficacy and safety for deep space missions

Frontiers in Space Technologies
The space environment is incredibly hostile, and humans are vulnerable in such conditions. Astronauts encounter various stress factors during a space journey, including radiation, microgravity, forceful acceleration during launch, altered magnetic fields,
Karen Barchetti, Karen Barchetti, Karen Barchetti, Audrey Derobertmasure, Audrey Derobertmasure, Audrey Derobertmasure, Pierre Boutouyrie, Pierre Boutouyrie, Pierre Boutouyrie, Piero Sestili   +9 more
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Poor Understanding of Radiation Profiles in Deep Space Causes Inaccurate Findings and Misleading Conclusions [PDF]

Journal of Biomedical Physics and Engineering, 2019
The radiation environment in deep space, where astronauts are behind the shelter provided by the Earth’s magnetosphere, is a major health concern. Galactic cosmic rays (GCR) and solar particle events (SPE) are two basic sources of space radiation in the ...
J J Bevelacqua, S M J Mortazavi
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Exploring Similarities Across the Space and Theater Industries

Frontiers in Psychology, 2021
Konstantin Chterev, Konstantin Chterev, Maria Eugenia Panero   +2 more
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Phylogenetic Solutions to the Radiosensitivity of the Primordial Follicle Pool

Hanggong uju uihakoeji
Ionizing radiation presents a significant risk during long duration spaceflight. Unlike the renewal of the male germ line, female reproductive capacity relies on a finite and non-renewable pool of primordial follicles.
Ümmü Gülsüm Keser, Zerrin Kozma
doaj   +1 more source