Results 61 to 70 of about 1,020,177 (314)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Asymmetric errors

Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment
We present a procedure for handling asymmetric errors. Many results in particle physics are presented as values with different positive and negative errors, and there is no consistent procedure for handling them. We consider the difference between errors quoted using pdfs and using likelihoods, and the difference between the rms spread of a measurement
Barlow R., Brazzale A. R., Volobouev I.
openaire   +2 more sources

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Catalytic enantioselective intramolecular hydroamination of alkenes using chiral aprotic cyclic urea ligand on manganese (II)

Nature Communications
Asymmetric catalysis for enantioselective intramolecular hydroamination of alkenes is a critical method in the construction of enantioenriched nitrogen-containing rings, often prevalent in biologically active compounds and natural products.
Bin Cui, Yuting Zheng, Hui Sun, Huijian Shang, Man Du, Yuxuan Shang, Cafer T. Yavuz   +6 more
doaj   +1 more source

Le limonène dans les huiles essentielles  : énantiomères et activités biologiques

Comptes Rendus. Chimie
Literature data are used to identify the enantiomeric diversity of limonene in 54 essential oils composed of between 0.3–99.7% of this molecule. Significant enantiomeric excesses are observed, either in (R)-(+)-, or in (S)-(–)-limonene, and more rarely ...
Aribi-Zouioueche, Louisa
doaj   +1 more source

Influence of friction coefficient asymmetry on vibration and stability of rolling mills during hot rolling

工程科学学报, 2019
The modern rolling industry has improved product quality, and the technical requirements of high accuracy and high dynamic performance have made the issue of rolling mill vibration more prominent.
Jin-lei HUANG, Yong ZANG, Zhi-ying GAO
doaj   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

An Eight-Step Continuous-Flow Total Synthesis of Vitamin B1

Engineering
Vitamin B1 is widely applied in the healthcare and food industry as an antineuritic and antioxidant to maintain the normal functioning of nerve conduction, the heart, and the gastrointestinal tract.
Meifen Jiang, Minjie Liu, Weijian Li, Yingqi Xia, Fen-Er Chen   +4 more
doaj   +1 more source

Parametric study of a novel asymmetric micro-gripper mechanism

Journal of Advanced Mechanical Design, Systems, and Manufacturing, 2015
Aiming at the requirements of micro-assembly for the microtubule (diameter of 0-200μm) components, a new type of asymmetric flexible micro-gripper mechanism based on flexure hinges was designed and studied.
Qingsong XING, Youhua GE
doaj   +1 more source