Results 71 to 80 of about 698,577 (309)

Parametric study of a novel asymmetric micro-gripper mechanism

open access: yesJournal of Advanced Mechanical Design, Systems, and Manufacturing, 2015
Aiming at the requirements of micro-assembly for the microtubule (diameter of 0-200μm) components, a new type of asymmetric flexible micro-gripper mechanism based on flexure hinges was designed and studied.
Qingsong XING, Youhua GE
doaj   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

open access: yesFEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard   +12 more
wiley   +1 more source

Tuning the properties of coumarin-based small molecule donors via strong acceptor substitution for advanced donor/PCBM organic solar cells

open access: yesScientific African
In this study, we designed and evaluated high-efficiency coumarin-based small-molecule donors for organic solar cells (OSCs) using density functional theory (DFT) calculations to address the challenge of improving charge transfer and photovoltaic ...
Walid Taouali   +2 more
doaj   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

open access: yesFEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Optimal prediction under asymmetric loss [PDF]

open access: yes
Prediction problems involving asymmetric loss functions arise routinely in many fields, yet the theory of optimal prediction under asymmetric loss is not well developed.
Francis X. Diebold   +1 more
core  

Heterotropic regulation and negative homotropic cooperativity

open access: yesFEBS Open Bio, EarlyView.
We identified a structural module common to some proteins that couple negative cooperativity with heterotropic regulation, two features that rarely coexist. These proteins are ring‐like and present an ordered asymmetry whereby noncontacting subunits are symmetric, and their tertiary structure differs from that of contacting subunits.
Veronica Morea   +5 more
wiley   +1 more source

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

open access: yesAging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

Carbohydrate-Based Hydrogels: Weaving Nature’s Versatility into Biomedical Innovation

open access: yesInternational Journal of Nanomedicine
Camilla Maria Cova, Alessio Zuliani, Noureddine Khiar Asymmetric Synthesis and Nanosystems Group (Art&Fun), Institute for Chemical Research (IIQ), CSIC-University of Seville, Seville, 41092, SpainCorrespondence: Noureddine Khiar, Asymmetric Synthesis
Cova CM, Zuliani A, Khiar N
doaj  

Profound Leadership Strategies: Transcending the Leadership Crisis in the Age of Artificial Intelligence

open access: yesNew Directions for Adult and Continuing Education, EarlyView.
ABSTRACT This article examines the evolving role of organizational leadership amidst the rapid advancements in artificial intelligence (AI). It explores a broadly experienced and documented crisis in leadership, due in part to the disruptive nature of AI and emerging technology.
Rachel Wlodarsky, Davin Carr Chellman
wiley   +1 more source

Copper complex catalyzed asymmetric monosulfonylation of meso-vic-diols [PDF]

open access: yes, 2007
Asymmetric desymmetrization of meso-vic-diols was performed by tosylation in the presence of copper(II) triflate and (R,R)-Ph-BOX as a catalyst. The method was successfully applied to asymmetric desymmetrization of cyclic and acyclic meso-vic-diols in ...
Demizu, Yosuke   +3 more
core   +1 more source

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