Results 271 to 280 of about 37,178 (323)
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Asymmetrical flow field-flow fractionation for the analysis of PEG-asparaginase
Talanta, 2016Monomethoxypolyethylene glycol L-asparaginase (PEG-ASNASE) is the PEGylated version of the enzyme L-asparaginase (ASNASE). Both are used for remission induction in acute lymphoblastic leukemia (ALL) and non-Hodgkin's lymphoma (NHL). The treatment control is generally carried out by performing activity assays, though methods to determine the actual ...
C, John +4 more
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Fractionation of Prion Protein Aggregates by Asymmetrical Flow Field‐Flow Fractionation
2006Achieving the successful separation and analysis of amyloid and other large protein aggregates can be a difficult proposition. Field-flow fractionation (FFF) is a flow-based separation method like chromatography; however, FFF is capable of high-resolution separations in the absence of a stationary matrix.
Jay R, Silveira +2 more
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Analysis of Peptides using Asymmetrical Flow Field-flow Fractionation (AF4)
Journal of Pharmaceutical Sciences, 2021While asymmetrical flow field-flow fractionation (AF4) has been widely used for separation of high molecular weight species and even particles, its ability to resolve lower molecular weight species has rarely been explored. Over the course of many projects, we have discovered that AF4 can be an effective analytical method for separating peptides from ...
Ryan R, Manning +6 more
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Asymmetric Flow Field-Flow Fractionation Investigation of Magnetopolyplexes
Macromolecular Chemistry and Physics, 2015Asymmetric flow field-flow fractionation (AF4) is an analytical separation technique capable of providing information on different parameters of complex systems in a single measurement. Although it shows promise to be an important tool in the field of gene therapy, AF4 has only occasionally been used to study gene delivery vectors such as polyplexes ...
Haladjova E. +6 more
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International journal of pharmaceutics
This study employs asymmetric flow field-flow fractionation online coupled with small angle X-ray scattering at a synchrotron beamline, along with multiple downstream detectors, including multi-angle light scattering, dual wavelength UV and dRI.
Anna-Maria Börjesdotter +6 more
semanticscholar +1 more source
This study employs asymmetric flow field-flow fractionation online coupled with small angle X-ray scattering at a synchrotron beamline, along with multiple downstream detectors, including multi-angle light scattering, dual wavelength UV and dRI.
Anna-Maria Börjesdotter +6 more
semanticscholar +1 more source
Journal of Chromatography A
Drug development is a complex multi-stage process that aims to deliver therapeutic products to the market. This process employs different analytical methods to separate and characterise compounds, monitor manufacturing, and validate the final drug ...
Klaus Richter +2 more
semanticscholar +1 more source
Drug development is a complex multi-stage process that aims to deliver therapeutic products to the market. This process employs different analytical methods to separate and characterise compounds, monitor manufacturing, and validate the final drug ...
Klaus Richter +2 more
semanticscholar +1 more source
Flow optimisations with increased channel thickness in asymmetrical flow field-flow fractionation
Journal of Chromatography A, 2018Retention in flow field-flow fractionation (flow FFF) is generally governed by the combination of crossflow and migration flowrates. Especially for an asymmetrical flow FFF (AF4) channel in which the channel-inlet flow is divided into crossflow and outflow, the separation of low-molecular-weight proteins or macromolecules requires a relatively high ...
Joon Seon Yang, Myeong Hee Moon
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Journal of Chromatography A, 2021
The steadily rising interest in the investigation of interactions between nanomaterials and biological media has also led to an increasing interest in asymmetrical flow field-flow fractionation (AF-FFF). The biggest strength of AF-FFF is the possibility to alter the flow profiles to suit a specific separation problem. In this paper, the influence of an
Martin Berger +6 more
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The steadily rising interest in the investigation of interactions between nanomaterials and biological media has also led to an increasing interest in asymmetrical flow field-flow fractionation (AF-FFF). The biggest strength of AF-FFF is the possibility to alter the flow profiles to suit a specific separation problem. In this paper, the influence of an
Martin Berger +6 more
openaire +2 more sources
Chromatography (Basel), 2015 In this report we demonstrate a practical multivariate design of experiment (DoE) approach for asymmetric flow field-flow fractionation (AF4) method optimization using separation of lipoprotein subclasses as an example.
Zsuzsanna Kuklenyik +2 more
exaly +2 more sources
Journal of Chromatography A, 2020
Aquatic ecosystems are facing multiple direct and indirect stressors from anthropogenic activities. Aquatic colloids, including natural and manufactured nanoparticles, have received global concern owing to their ability to transport metals, nutrients and
Yu Wang, C. Cuss, W. Shotyk
semanticscholar +1 more source
Aquatic ecosystems are facing multiple direct and indirect stressors from anthropogenic activities. Aquatic colloids, including natural and manufactured nanoparticles, have received global concern owing to their ability to transport metals, nutrients and
Yu Wang, C. Cuss, W. Shotyk
semanticscholar +1 more source