Results 51 to 60 of about 9,951,458 (265)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Increasing the resolution of field flow fractionation with increasing crossflow gradients [PDF]

, 2023
The resolution of flow field flow fractionation (flow FFF) depends primarily on the crossflow rate and its change over time. In this work we demonstrate a method for modulation of the crossflow rate during separation increases the peak-to-peak resolution
George, Bou-Assaf, Nicholas, Larson
core   +1 more source

Impact of asymmetrical flow field-flow fractionation on protein aggregates stability [PDF]

Journal of Chromatography A, 2016
The impact of asymmetrical flow field-flow fractionation (AF4) on protein aggregate species is investigated with the aid of multiangle light scattering (MALS) and dynamic light scattering (DLS). The experimental parameters probed in this study include aggregate stability in different carrier liquids, shear stress (related to sample injection), sample ...
Carmen R M, Bria, S Kim Ratanathanawongs, Williams   +1 more
openaire   +2 more sources

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

The Contribution of Endmembers to Mixtures of Leaf Leachates and Riverine DOM can be Determined by Measuring Their Size and Fluorescence Properties

Frontiers in Environmental Chemistry, 2022
The molecular mass distribution (MMD) and fluorescence properties of dissolved organic matter (DOM) are important characteristics for tracing and predicting its pathways, processes, and fate in aquatic systems. For the first time, asymmetrical flow field-
C. W. Cuss, C. Guéguen
doaj   +1 more source

Comparative assessment of crystallographic and cryo‐EM models in the Protein Data Bank

FEBS Open Bio, EarlyView.
Raw data obtained by X‐ray crystallography or cryo‐EM result in experimental maps, ultimately fitted by atomic models. Although the physical principles are different, the final results can be viewed, compared, and evaluated in the same way. With cryogenic electron microscopy (cryo‐EM) on track to surpass X‐ray crystallography as the preferred method ...
Alexander Wlodawer, Pawel Rubach, Zbigniew Dauter, Wojciech Dec, Dariusz Brzezinski, Marta Kulik, Wladek Minor, Mariusz Jaskolski   +7 more
wiley   +1 more source

Comprehensive Characterization of 98 Chinese Cases of Genetic Creutzfeldt‐Jakob Disease With T188K Mutation

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To characterize the demographic, clinical, and laboratory features of the Chinese patients of genetic Creutzfeldt‐Jakob disease with T188K variant (T188K‐gCJD), the most common subtype of genetic prion diseases (gPrDs) in China. Methods In this nationwide retrospective study, data from 98 genetically confirmed T188K‐gCJD patients ...
Chun‐Jie Li, Dong‐Lin Liang, Li‐Ping Gao, Wei‐Wei Zhang, Wei Zhou, A. Ruhan, Bing Xu, Run‐Dong Cao, Kang Xiao, Cao Chen, Qi Shi, Xiao‐Ping Dong   +11 more
wiley   +1 more source

Turbulent structures, integral length scale and turbulent kinetic energy (TKE) dissipation rate in compound channel flow [PDF]

, 2017
In the present study, high data rate measurements were obtained for the streamwise and vertical velocity components using 2D Laser Doppler Velocimeter. The turbulent field in a straight compound-channel flow was characterized for three different uniform ...
Roja-Solórzano, Luís R., Bento Leal, João, Ricardo, Azevedo, Azevedo, Ricardo   +3 more
core   +1 more source

A clearer understanding of the dynamic structuring of different natural rubber genotypes on a macroscopic and mesoscopic scale by asymmetrical-flow field-flow fractionation (A4F) analysis

Polymer Testing
Unlike synthetic elastomers, the structure of natural rubber (NR) evolves (dynamic structuring) and so do its properties during the storage before reaching an industrial mixer. In the rubber industry this is known as storage hardening.
Siriluck Liengprayoon, Christine Char, Laurent Vaysse, Frédéric Bonfils   +3 more
doaj   +1 more source

Multiscale Structure of Starches Grafted with Hydrophobic Groups: A New Analytical Strategy

Molecules, 2020
Starch, an abundant and low-cost plant-based glucopolymer, has great potential to replace carbon-based polymers in various materials. In order to optimize its functional properties for bioplastics applications chemical groups need to be introduced on the
Chloé Volant, Alexandre Gilet, Fatima Beddiaf, Marion Collinet-Fressancourt, Xavier Falourd, Nicolas Descamps, Vincent Wiatz, Hervé Bricout, Sébastien Tilloy, Eric Monflier, Claude Quettier, Ahmed Mazzah, Agnès Rolland-Sabaté   +12 more
doaj   +1 more source