Results 91 to 100 of about 2,094,291 (308)

A Rare De Novo Missense Mutation in IFT122 Confers a Genetic Susceptibility Factor of Idiopathic Pediatric Uveitis Via Trio‐based Whole‐Exome Sequencing

Advanced Science, EarlyView.
A rare de novo IFT122‐A773E variant is identified in idiopathic pediatric uveitis and shown to exacerbate retinal inflammation and barrier dysfunction. Mechanistically, the variant enhances IFT43 interaction, elevates calcium signaling, and activates the MEK/ERK/FRA1 axis, revealing a previously unrecognized cilia‐associated pathway that may increase ...
Qian Zhou, Jiaxing Huang, Yilin Wang, Xingran Li, Xianyang Liu, Lingyu Dai, Hongshun Li, Qingfeng Wang, Jiangyi Liu, Guannan Su, Wanyun Zhang, Yang Deng, Qingfeng Cao, Yujie Lai, Xiang Luo, Changwei Huang, Ling Chen, Shengping Hou, Peizeng Yang   +18 more
wiley   +1 more source

The assessment of transmission efficiency and latent infection period in asymptomatic carriers of SARS-CoV-2 infection

International Journal of Infectious Diseases, 2020
Few studies have focused on the transmission efficiency of asymptomatic carriers of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Our follow-up study was performed on 147 asymptomatic carriers in Anhui Province.
Zhirong Liu, Ruilin Chu, Lei Gong, Bin Su, Jiabing Wu   +4 more
doaj   +1 more source

Prevalence and characteristics of asymptomatic norovirus infection in the community in England. [PDF]

, 2010
Norovirus is a major cause of infectious intestinal disease, and a substantial prevalence of asymptomatic infection has been reported. We describe the prevalence, seasonality and characteristics of asymptomatic norovirus infection in England.
Tam, CC, Phillips, G, Lopman, B, Rodrigues, LC   +3 more
core   +1 more source

Potential of Nanoparticle‐Based Phototherapies for Future Treatment of Uveal Melanoma

Advanced Science, EarlyView.
This review evaluates nanoparticle‐based phototherapies for uveal melanoma, highlighting emerging strategies to enhance tumor targeting, light delivery, and treatment precision. Preclinical data indicate improved efficacy and reduced toxicity, supporting their potential to enhance localized treatment and future translational advances. (Generated by the
Emilie Lambert, Christophe Nguyen, Sean Edward Dunn, Magali Gary‐Bobo, Jérôme Lacombe, Justin Moser, Frédéric Zenhausern, Jean‐Olivier Durand, Frédérique Cunin   +8 more
wiley   +1 more source

European multicentre study on outcome of surgery for sporadic primary hyperparathyroidism

BJS (British Journal of Surgery), EarlyView., 2020
Some 5861 patients undergoing first‐time surgery for sporadic primary hyperparathyroidism were registered in the Eurocrine® database between 2015 and 2018. The use of intraoperative parathyroid hormone measurement decreased the risk of conversion and persistent hypercalcaemia.
A. Bergenfelz, S. van Slycke, Ö. Makay, L. Brunaud   +3 more
wiley   +1 more source

Asymptomatic, Mild, and Severe Influenza A(H7N9) Virus Infection in Humans, Guangzhou, China [PDF]

, 2014
Targeted surveillance for influenza A(H7N9) identified 21 cases of infection with this virus in Guangzhou, China, during April 1, 2013–March 7, 2014. The spectrum of illness ranged from severe pneumonia to asymptomatic infection.
Liu, Y, Biao Di, Hui Wang, Chen, Z, Li, K, Luo, L, Yufei Liu, Di, B, Lu, J, Jianyun Lu, Yang, Z, Hui Liu, Eric H.Y. Lau, Zongqiu Chen, Wang, H, Liu, H, Zongqiu Chen, Zhicong Yang, Kuibiao Li, Lau, EHY, Lei Luo, Xiao, X, Xincai Xiao   +22 more
core   +1 more source

Gut Microbial Topology and Metabolic Signatures Associated With Colorectal Neoplasia

Advanced Science, EarlyView.
The gut microbiota organizes into two robust association patterns linked to colorectal neoplasia risk. Topological shifts in microbial networks are associated with metabolite alterations and may shape host responses during disease development. ABSTRACT Alterations of gut microbial communities impact health.
Kai Song, Youwen Qin, Jiahui Luo, Liping Liu, Chenyu Luo, Yinbin Qiu, Yiyi Zhong, Huanzi Zhong, Kui Wu, Meng Ni, Dong Wu, Min Dai, Shida Zhu, Hongda Chen   +13 more
wiley   +1 more source

Characterising temporal trends in asymptomatic Plasmodium infections and transporter polymorphisms during transition from high to low transmission in Zanzibar, 2005-2013. [PDF]

, 2015
BACKGROUND: Improved understanding of the asymptomatic malaria parasite reservoir is a prerequisite to pursue malaria elimination efforts. We therefore characterised temporal trends and transporter polymorphisms in asymptomatic Plasmodium infections ...
Msellem, Mwinyi, Mårtensson, Andreas, Bjorkman, A., Martensson, A., Petzold, Max,, Xu, W. P., Ali, A. S., Ali, Abdullah S, Bhattarai, A., Froberg, G., Xu, Weiping, Cook, Jackie, Bhattarai, Achuyt, Msellem, M. I., Abass, A., Björkman, Anders, Morris, Ulrika, Petzold, Max, Ali, Abdullah, Mårtensson, Andreas,, Cook, J., Abass, Ali, Shakely, Delér, Greenhouse, Bryan, Schwartz, Alanna, Schwartz, A., Shakely, D., Fröberg, Gabrielle, Greenhouse, B., Morris, U., Msellem, Mwinyi I, Msellem, MI, Petzold, M, Shakely, D, Cook, J, Greenhouse, B, Bhattarai, A, Xu, W, Morris, U,, Schwartz, A, Abass, A   +40 more
core   +1 more source

SARS-CoV-2 infection, clinical features and outcome of COVID-19 in United Kingdom nursing homes [PDF]

, 2020
OBJECTIVES: To understand SARS-Co-V-2 infection and transmission in UK nursing homes in order to develop preventive strategies for protecting the frail elderly residents.
McLaren, R, Graham, N.S.N., Sanderson, F., Wingfield, D., Storch, M., Storch, M, Elliott, P, Downes, R., Randell, P., Cameron, L, Lang, N, Junghans, C, Freemontl, P.S., Graham, Nsn, McKirdy, A., McLaren, R., Lai, H, Priestman, M., Sendall, C, Downes, R, Priestman, M, Ciechonska, M, Ladhani, S, Wingfield, D, Sanderson, F, Crone, MA, Lang, N., Sharp, DJ, Howard, R., Junghans, C., Elliott, P., Cameron, L., Sharp, D.J., Ladhani, S., McKirdy, A, Freemont, PS, Sendall, C., Crone, M.A., Lai, H., Ciechonska, M., Howard, R, Randell, P   +41 more
core   +1 more source

Metabolic Signatures for Liver Cancer Diagnosis and Mechanistic Insights: A Large‐Scale, Multicenter Study

Advanced Science, EarlyView.
A large‐scale multicenter serum metabolomics study (13 centers, n = 2,149) identified a 9‐metabolite + AFP diagnostic signature for liver cancer (AUC = 0.93). Among the signature, nicotinamide (NAM) was validated as an oncometabolite: NAM enhances NAD+ synthesis, activating SIRT1 to deacetylate and stabilize HIF1α, thereby driving glycolysis, MAPK ...
Yongjie Xu, Jiachen Wang, Chunmeng Ding, Changfa Xia, Yunyong Liu, Yuanjie Zheng, Sheng Chang, Shaokai Zhang, Yutong He, Ruifang Sun, Yunfeng Xi, Yan Liu, Kun Qian, Wanqing Chen   +13 more
wiley   +1 more source