Results 71 to 80 of about 8,781 (261)

ACSL4‐Dependent Lysosomal Lipid Peroxidation Links WTAP‐Mediated m6A Modification to Intervertebral Disc Degeneration

Advanced Science, EarlyView.
IL‐1β upregulates the protein level of WTAP, which promotes the m6A modification of ACSL4 mRNA in an IGF2BP2‐dependent manner, thereby enhancing its stability. The increased ACSL4 drives lipid peroxidation, leading to lysosomal membrane permeabilization (LMP) and impaired mitophagy, which collectively accelerate intervertebral disc degeneration (IVDD).
Shu Jia, Xu Gao, Laimin Zhu, Haixia Song, Jing Wu, Shang Chen, Sheng Gao, Lu Zhang, Chunyang Meng   +8 more
wiley   +1 more source

Tau Aggregate Imaging and Transcriptomics of Alzheimer's Disease Brain at Different Stages of Disease

Advanced Science, EarlyView.
The protein aggregates and gene expression in the middle temporal gyrus (MTG) and somatosensory cortex (SOM) of the postmortem brains of 13 Alzheimer's disease patients were studied in detail, revealing that small hyperphosphorylated tau aggregates increase with Braak stage driven by microglial inflammation.
Elizabeth A. English, Dorothea Böken, Matthew W. Cotton, Matthew R. Cheetham, Johanna S. Jackson, Georg Meisl, John S. H. Danial, Paul M. Matthews, Nurun N. Fancy, David Klenerman   +9 more
wiley   +1 more source

Transfer Entropy for Nonparametric Granger Causality Detection: An Evaluation of Different Resampling Methods

Entropy, 2017
The information-theoretical concept transfer entropy is an ideal measure for detecting conditional independence, or Granger causality in a time series setting.
Cees Diks, Hao Fang
doaj   +1 more source

Seeing the Chemistry of Biomolecular Condensates: In Situ Mapping of Composition and Water Content

Advanced Science, EarlyView.
Raman hyperspectral imaging combined with spectral phasor analysis enables a label‐free quantification of proteins, polymers and water density within individual biomolecular condensates. By transforming complex vibrational fingerprints into intuitive compositional maps, the approach reveals the high water content and structural heterogeneity of ...
E. Sabri, A. Mangiarotti, C. N. Z. Schmitt, R. Dimova   +3 more
wiley   +1 more source

Bivariate tail estimation: dependence in asymptotic independence

Bernoulli, 2004
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Draisma, Gerrit, Drees, Holger, Ferreira, Ana, De Haan, Laurens   +3 more
openaire   +5 more sources

Low‐Power Control Of Resistance Switching Transitions in First‐Order Memristors

Advanced Electronic Materials, EarlyView.
Joule losses are a serious concern in modern integrated circuit design. In this regard, minimizing the energy necessary for programming memristors should be handled with care. This manuscript presents an optimal control framework, allowing to derive energy‐efficient programming voltage protocols for resistance switching devices. Following this approach,
Valeriy A. Slipko, Alon Ascoli, Fernando Corinto, Yuriy V. Pershin   +3 more
wiley   +1 more source

Asymptotic Independence in the Multivariate Central Limit Theorem

The Annals of Probability, 1979
Necessary and sufficient conditions are given for asymptotic independence in the multivariate central limit theorem. If $\{X_n\}$ is a sequence of independent, identically distributed random variables whose common distribution is symmetric, and if the distribution of $X^2_1$ is in the domain of attraction of a stable distribution of characteristic ...
Hudson, William N., Tucker, Howard G.
openaire   +2 more sources

Nonlinear Dynamics and Invariants of Motion in ReRAM Cells

Advanced Electronic Materials, EarlyView.
A second‐order cell, hosting one capacitor and two back‐to‐back ReRAMs, admits Invariants of Motion: its states lie on one‐dimensional manifolds at all times. The cell shows quiescent monostability or bistability, depending on the manifold index. At equilibrium, the capacitor voltage vanishes.
Mauro Di Marco, Mauro Forti, Luca Pancioni, Giacomo Innocenti, Alberto Tesi, Alon Ascoli   +5 more
wiley   +1 more source

An IID Test for Functional Time Series with Applications to High-Frequency VIX Index Data

Risks
To address a key issue in functional time series analysis on testing the randomness of an observed series, we propose an IID test for functional time series by generalizing the Brock–Dechert–Scheinkman (BDS) test, which is commonly used for testing ...
Xin Huang, Han Lin Shang, Tak Kuen Siu
doaj   +1 more source

Asymptotic Law of the jth Records in the Bivariate Exponential Case

Journal of Mathematics, 2014
We consider a sequence (Xi,Yi)1⩽i⩽n of independent and identically distributed random variables with joint cumulative distribution  H(x,y), which has exponential marginals F(x) and G(y) with parameter λ=1.
Grine Azedine
doaj   +1 more source