Results 171 to 180 of about 8,872 (261)

Reconsidering Volume‐Based Drug Procurement Policy: The Consequences of Manufacturers' Optimal Production Planning and Breach Strategies

Naval Research Logistics (NRL), EarlyView.
ABSTRACT This paper examines the impacts of Volume‐Based Procurement (VBP) policies on pharmaceutical supply chains, with a focus on the strategic behaviors of manufacturers. VBP aims to reduce costs and stabilize supplies by centralizing procurement through competition based on volumes and prices.
Nani Zhou, Tong Wang, Guohua Wan
wiley   +1 more source

On flexible covariate adjustment under covariate-constrained randomization. [PDF]

Clin Trials
Wang B, Li F.
europepmc   +1 more source

Optimal Designs and Inspection Time Decisions for Gamma Accelerated Degradation Tests

Naval Research Logistics (NRL), EarlyView.
ABSTRACT This study analytically derives optimal designs for gamma accelerated degradation tests while incorporating inspection time as a design variable under both D‐ and V‐optimality criteria. Under D‐optimality, we prove that the optimal design allocates test units exclusively to the lowest and highest stress levels and adopts the longest inspection
Hung‐Ping Tung, I‐Chen Lee
wiley   +1 more source

Deep learning for the change-point Cox model with current status data. [PDF]

Lifetime Data Anal
Huang Q, Feng A, Wu Q, Tong X.
europepmc   +1 more source

Optimal Control Analysis of Vertically Transmitted Infectious Diseases With Saturated Incidence and Nonlinear Treatment

Optimal Control Applications and Methods, EarlyView.
Schematic representation of the proposed disease transmission model incorporating vertical transmission, saturated incidence, and nonlinear treatment. The study combines theoretical analysis, bifurcation and stability investigations, and optimal control techniques to evaluate prevention and treatment interventions.
Oludolapo A. Olanrewaju, Sulaimon F. Abimbade   +1 more
wiley   +1 more source

Fast Estimation and Valid Statistical Inference for Mixed-Effect Location-Scale Models Using Variational Inference. [PDF]

Stat Med
Wu BP, Hedeker D.
europepmc   +1 more source

Leaf heat tolerance in a native Californian shrub responds in expected and unexpected ways to differences in range, season, and sunlight exposure

PLANTS, PEOPLE, PLANET, EarlyView.
Earth's ecosystems are experiencing wide‐ranging impacts from global climate change, including increased average and extreme temperatures. These temperature shifts can drastically affect plant physiology, threatening the future of even common plant species. Here, we focus on photosynthetic function in a native Southern California shrub species.
Anna K. M. Bowen, Helen Holmlund, Anna L. Jacobsen, R. Brandon Pratt, Christine Scoffoni, Ishan Ashford, Olivia Plumb, Casey Wisely, Gretchen North   +8 more
wiley   +1 more source

Non-Parametric Goodness-of-Fit Tests Using Tsallis Entropy Measures. [PDF]

Entropy (Basel)
Cadirci MS.
europepmc   +1 more source

Informing the potential of mature temperate forests as natural climate solutions: Changed fine root biomass and morphology under elevated CO2

PLANTS, PEOPLE, PLANET, EarlyView.
The land carbon sink absorbs approximately 25% of anthropogenic CO2 emissions, with forests accounting for most. Managing forests as Natural Climate Solutions is therefore a societal imperative, requiring models of where and how long carbon resides within these ecosystems. We investigated the effects of elevated CO2 on fine roots, the primary source of
Grace Handy, Angeliki Kourmouli, Marie Arnaud, Carolina Mayoral, Richard J. Norby, Michaela K. Reay, Sami Ullah, Iain P. Hartley, R. Liz Hamilton, Robert Grzesik, Andy R. Smith, Elena Vanguelova, A. Rob MacKenzie, Adriane Esquivel‐Muelbert   +13 more
wiley   +1 more source