Results 121 to 130 of about 4,474,845 (304)

Initial Distance‐Dependent Mean Force Drives Synaptic Vesicle Motion Toward Fusion Sites in Stimulated Hippocampal Neurons

open access: yesAdvanced Science, EarlyView.
Synaptic vesicle (SV) motion and exocytosis dynamics in the presynaptic terminals of live neurons are intimately linked to synaptic transmission during neuronal activity. In this work, it is revealed that, during electrical stimulation, SVs located farther from their fusion sites exhibit greater straightness and experience larger mean forces directed ...
Gyunam Park   +7 more
wiley   +1 more source

Asymptotic expansions and effective boundary conditions: a short review for smooth and nonsmooth geometries with thin layers★

open access: yesESAIM: Proceedings and Surveys, 2018
Problems involving materials with thin layers arise in various application fields. We present here the use of asymptotic expansions for linear elliptic problems to derive and justify so-called ap-proximate or effective boundary conditions.
Auvray Alexis, Vial Grégory
doaj   +1 more source

An asymptotic optimality result for the multiclass queue with finite buffers in heavy traffic

open access: yesStochastic Systems, 2015
For a multiclass G/G/1 queue with finite buffers, admission and scheduling control, and holding and rejection costs, we construct a policy that is asymptotically optimal in the heavy traffic limit.
Rami Atar, Mark Shifrin
doaj   +1 more source

Engineered GM1 Intersects Between Mitochondrial and Synaptic Pathways to Ameliorate ALS Pathology

open access: yesAdvanced Science, EarlyView.
Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease driven by genetic and molecular disruptions affecting energy balance, protein homeostasis, and stress responses in nerve cells. Studies using human and rodent models identified convergent defects in mitochondria and synaptic function.
Federica Pilotto   +11 more
wiley   +1 more source

Lyapunov stabilizability of controlled diffusions via a superoptimality principle for viscosity solutions

open access: yes, 2005
We prove optimality principles for semicontinuous bounded viscosity solutions of Hamilton-Jacobi-Bellman equations. In particular we provide a representation formula for viscosity supersolutions as value functions of suitable obstacle control problems ...
Cesaroni, Annalisa
core  

OPTRACE: Optical Imaging–Guided Transplantation and Tracking of Cells in the Mouse Brain

open access: yesAdvanced Science, EarlyView.
OPTRACE establishes an optical, two‐step platform for intracerebral cell therapy. Transparent glass pipettes enable real‐time, image‐guided delivery, while multiplex genetic labeling with two‐photon and bioluminescence readouts supports longitudinal single‐cell tracking and host–graft dynamics.
Jinghui Wang   +10 more
wiley   +1 more source

Global dynamics of a cytokine-enhanced viral infection model with distributed delays and optimal control analysis

open access: yesAIMS Mathematics
This paper analyzed a cytokine-enhanced viral infection model incorporating three distributed delays: $ (1) $ Intracellular delays in infected $ {\rm CD4}^+ $ T cells induced by inflammatory cytokines and viruses, $ (2) $ delays in $ {\rm CD4}^+ $ T cell
Cuifang Lv, Xiaoyan Chen, Chaoxiong Du
doaj   +1 more source

Mathematical Prediction for Geometry‐Mediated Cell 3D In‐Growth on Bone Tissue Engineering Scaffolds

open access: yesAdvanced Science, EarlyView.
This study identifies a fundamental pore size dependent pattern of three dimensional bone marrow derived mesenchymal stem cell (BMSC) infiltration within porous scaffolds, where small pores promote horizontal cellular bridging and large pores facilitate vertical migration.
Xiang Gao   +15 more
wiley   +1 more source

Inference and Optimal Design on Partially Accelerated Life Tests for the Power Half-Logistic Distribution Under Adaptive Type II Progressive Censoring

open access: yesMathematics
This study explores accelerated life tests to examine the durability of highly reliable products. These tests involve applying higher stress levels, such as increased temperature, voltage, or pressure, that cause early failures.
Hanan Haj Ahmad, Mahmoud M. El-Awady
doaj   +1 more source

A Progressive Interval Type-I Censored Life Test Plan for Rayleigh Distribution

open access: yesAustrian Journal of Statistics, 2019
In this paper, we have considered the problem of optimal inspection times for the progressive interval type-I censoring scheme where uncertainty in the process is governed by the two-parameter Rayleigh distribution.
Arun Kaushik
doaj   +1 more source

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