Results 51 to 60 of about 752 (170)

ATAD3 duplications bridge mitochondrial diseases and Aicardi–Goutières syndrome

Developmental Medicine &Child Neurology, Volume 68, Issue 2, Page 287-294, February 2026.
ATAD3 locus duplications cause a severe neonatal mitochondrial disorder with neuroimaging features resembling interferonopathies, and suggest a mitochondrial nucleic acid‐triggered interferon response. Plain language summary: https://onlinelibrary.wiley.com/doi/10.1111/dmcn.16446 Abstract A recurrent 68‐kb heterozygous duplication of the ATAD3 locus ...
Pauline Planté‐Bordeneuve, Claire‐Marine Bérat, Sylvain Hanein, Cyril Gitiaux, ATAD3 Study Group, Julie Steffann, Isabelle Desguerre, Agnès Rötig, Nathalie Boddaert, Giulia Barcia, Brian Sperelakis‐Beedham, Zahra Assouline, Marie‐Thérèse Abi‐Warde, Rukhshona Abdullazoda, Agnès Guichet, Céline Bris, Aurélien Caux, Marlène Rio, Jérémy Bertrand, Pauline Gaignard, Alice Lepelley, Arnold Munnich, Manuel Schiff, Isabelle Desguerre, Agnès Rötig, Nathalie Boddaert, Giulia Barcia   +26 more
wiley   +1 more source

Real‐World Treatment Patterns in AERD: An Analysis of ATAD, Biologics, and Combination Therapy

International Forum of Allergy &Rhinology, Volume 16, Issue 1, Page 99-101, January 2026.
Key Points Contemporary aspirin exacerbated respiratory disorder (AERD) therapy commonly includes aspirin desensitization (55%) and biologics (48%). Aspirin desensitization therapy has higher discontinuation rates than biologics. Patients receiving biologics are younger, and ∼25% of the patients switch to other agents.
Nitish Kumar, Tyson Pace, Pedro Lança Gomes, Michael J. Marino, Amar Miglani, Devyani Lal   +5 more
wiley   +1 more source

A Dynamic Model of Predation

The RAND Journal of Economics, Volume 56, Issue 4, Page 738-755, Winter 2025.
ABSTRACT We study the feasibility and profitability of predation in a dynamic environment, using a parsimonious infinite‐horizon, complete information setting in which an incumbent repeatedly faces potential entry. When a rival enters, the incumbent chooses whether to accommodate or predate it; the entrant then decides whether to stay or exit.
Patrick Rey, Yossi Spiegel, Konrad Stahl
wiley   +1 more source

Swamped: On Depression and Vision

American Anthropologist, Volume 127, Issue 3, Page 415-423, September 2025.
ABSTRACT “Swamped” cracks open my experience of depression by exploring how a specific place—a swamp—acted on me to bring social and emotional injuries, but also modes of seeing that ultimately moved me out of the depression, to the fore. In writing from this specific place, I build on moments in which something—a desire for beauty, the luminosity of ...
Petra Rethmann
wiley   +1 more source

Memantine, Simvastatin, and Epicatechin Inhibit 7-Ketocholesterol-induced Apoptosis in Retinal Pigment Epithelial Cells But Not Neurosensory Retinal Cells In Vitro

Journal of Ophthalmic & Vision Research, 2020
Purpose: 7-ketocholesterol (7kCh), a natural byproduct of oxidation in lipoprotein deposits is implicated in the pathogenesis of diabetic retinopathy and age-related macular degeneration (AMD).
Aneesh Neekhra, Julia Tran, Parsa R. Esfahani, Kevin Schneider, Khoa Pham, Ashish Sharma, Marilyn Chwa, Saurabh Luthra, Ana L. Gramajo, Saffar Mansoor, Baruch D. Kuppermann, M. Cristina Kenney   +11 more
doaj   +1 more source

Longitudinal Impact of Parenting on Grit: Serial Mediating Effect of Gratitude and Life Satisfaction

International Journal of Psychology, Volume 60, Issue 4, August 2025.
ABSTRACT Despite previous research demonstrating the importance of positive parenting in fostering adolescents' grit levels, very little is known about the longitudinal pathway and underlying mechanism of this relationship. Therefore, we conducted a three‐wave longitudinal study over 18 months among a sample of Chinese adolescents.
Kelly Ka Lai Lam, Shan Zhao, Hongfei Du, Liuyue Huang, Peilian Chi   +4 more
wiley   +1 more source

ATAD (DIRECTIVE 2016/1164/EU) AND BEPS [PDF]

Challenges of the Knowledge Society, 2018
In the latest tax competition between the European countries, and not just them (as we will see that this is happening at a global level), made the private companies to chose the best optimization plan for their businesses in all areas so choosing the ...
Ancuta-Larisa TOMA
doaj  

Two‐Year Data of Tapered Dupilumab Shows High Effectiveness in Chronic Rhinosinusitis with Nasal Polyps With Nonsteroidal Anti‐inflammatory Drug‐Exacerbated Respiratory Disease

Allergy, Volume 80, Issue 6, Page 1737-1745, June 2025.
Two‐year data of tapered dupilumab shows high effectiveness in CRSwNP with NSAID‐exacerbated respiratory disease. We assessed whether dupilumab is equally effective in CRSwNP with NSAID‐exacerbated respiratory disease (N‐ERD) patients as in CRSwNP patients without N‐ERD (CRSwNP‐NOS; not otherwise specified).
H. B. E. Elzinga, J. J. Otten, M. E. Cornet, A. B. Rinia, R. J. L. Van Der Lans, W. J. Fokkens, S. Reitsma, PolyREG Consortium, F. C. A. Timmer, M. E. Cornet, A. B. Rinia, I. J. Kleiss, I. Krebbers, G. F. J. P. M. Adriaensen, L. B. L. Benoist, D. R. Hoven, S. Reitsma, W. J. Fokkens   +17 more
wiley   +1 more source

Quality of Life in NSAIDs-Exacerbated Respiratory Disease on or off Intranasal Lysine Aspirin Therapy

Applied Sciences
Background: Intranasal administration of lysine aspirin (LAS) is a safe and effective method for aspirin treatment after desensitisation (ATAD). Changes in quality of life (QoL) in patients on intranasal LAS have not been documented and we aimed to ...
Alfonso Luca Pendolino, Joshua Ferreira, Glenis K. Scadding, Peter J. Andrews   +3 more
doaj   +1 more source

Inpatient vaginal dinoprostone vs outpatient balloon catheters for cervical ripening in induction of labor: An individual participant data meta‐analysis of randomized controlled trials

Acta Obstetricia et Gynecologica Scandinavica, Volume 104, Issue 6, Page 1041-1055, June 2025.
Cervical ripening in the induction of labor with outpatient balloon catheters is probably less effective than inpatient vaginal dinoprostone, specifically in maternal overweight and obesity during pregnancy. The perinatal and maternal safety profiles are comparable.
Fei Chan, Malitha Patabendige, Michelle R. Wise, John M. D. Thompson, Lynn Sadler, Michael Beckmann, Amanda Henry, Madeleine N. Jones, Ben W. Mol, Wentao Li   +9 more
wiley   +1 more source