Results 1 to 10 of about 2,542 (235)

W361R mutation in GaaR, the regulator of D‐galacturonic acid‐responsive genes, leads to constitutive production of pectinases in Aspergillus niger [PDF]

MicrobiologyOpen, 2019
Polysaccharides present in plant biomass, such as pectin, are the main carbon source for filamentous fungi. Aspergillus niger naturally secretes pectinases to degrade pectin and utilize the released monomers, mainly D‐galacturonic acid.
Ebru Alazi, Jing Niu, Simon B. Otto, Mark Arentshorst, Thi T. M. Pham, Adrian Tsang, Arthur F. J. Ram   +6 more
doaj   +3 more sources

Unraveling the regulation of sugar beet pulp utilization in the industrially relevant fungus Aspergillus niger [PDF]

iScience, 2022
Summary: Efficient utilization of agro-industrial waste, such as sugar beet pulp, is crucial for the bio-based economy. The fungus Aspergillus niger possesses a wide array of enzymes that degrade complex plant biomass substrates, and several regulators ...
Sandra Garrigues, Roland S. Kun, Mao Peng, Diane Bauer, Keykhosrow Keymanesh, Anna Lipzen, Vivian Ng, Igor V. Grigoriev, Ronald P. de Vries   +8 more
doaj   +2 more sources

Targeting lipid metabolism as a new therapeutic strategy for inherited cardiomyopathies [PDF]

Frontiers in Cardiovascular Medicine, 2023
Inherited cardiomyopathies caused by pathological genetic variants include multiple subtypes of heart disease. Advances in next-generation sequencing (NGS) techniques have allowed for the identification of numerous genetic variants as pathological ...
Karen R. Gaar-Humphreys, Karen R. Gaar-Humphreys, Alyssa van den Brink, Alyssa van den Brink, Mark Wekking, Mark Wekking, Folkert W. Asselbergs, Folkert W. Asselbergs, Frank G. van Steenbeek, Frank G. van Steenbeek, Frank G. van Steenbeek, Magdalena Harakalova, Magdalena Harakalova, Magdalena Harakalova, Jiayi Pei, Jiayi Pei, Jiayi Pei   +16 more
doaj   +2 more sources

Inducer-independent production of pectinases in Aspergillus niger by overexpression of the D-galacturonic acid-responsive transcription factor gaaR [PDF]

Applied Microbiology and Biotechnology, 2018
The transcription factor GaaR is needed for the expression of genes required for pectin degradation and transport and catabolism of the main degradation product, D-galacturonic acid (GA) in Aspergillus niger.
Ebru Alazi, Marcos Di Falco, Ian D Reid   +2 more
exaly   +3 more sources

Genetic Basis of Dilated Cardiomyopathy in Dogs and Its Potential as a Bidirectional Model [PDF]

Animals, 2022
Cardiac disease is a leading cause of death for both humans and dogs. Genetic cardiomyopathies, including dilated cardiomyopathy (DCM), account for a proportion of these cases in both species. Patients may suffer from ventricular enlargement and systolic
Karen R. Gaar-Humphreys, Talitha C. F. Spanjersberg, Giorgia Santarelli, Guy C. M. Grinwis, Viktor Szatmári, Bernard A. J. Roelen, Aryan Vink, J. Peter van Tintelen, Folkert W. Asselbergs, Hille Fieten, Magdalena Harakalova, Frank G. van Steenbeek   +11 more
doaj   +2 more sources

Revitalizing Pleurotus eryngii polysaccharides: gamma irradiation boosts antidiabetic and antioxidant potential [PDF]

Bioresources and Bioprocessing
Polysaccharides derived from Pleurotus eryngii possess various bioactive properties, including antioxidant, antidiabetic, anti-inflammatory, and immunomodulatory effects. In this study, polysaccharides were extracted from P.
Eman H. F. Abd El-Zaher, Ehab M. Tousson, Azza A. Mostafa, Enas M. El-Gaar, Galal Yahya, Yehia A.-G. Mahmoud   +5 more
doaj   +2 more sources

Species-specific, accession-specific, and common responses of foliar phytohormones and morphological traits to drought and herbivory [PDF]

BMC Plant Biology
Background Plants are exposed to various environmental challenges. Especially with ongoing climate change, droughts and insect outbreaks are expected to become more frequent.
Xue Xiao, Kruthika Sen Aragam, Andrea Bräutigam, Thomas Dussarrat, Selina Gaar, Maximilian Hanusch, Robin Heinen, Marvin Hildebrandt, Ruth Jakobs, Robert R. Junker, Radhika Keshan, Judit V. Mendoza Servín, Elikplim A. Setordjie, Yonca B. Seymen, Anke Steppuhn, Sybille B. Unsicker, Nicole M. van Dam, Baris Weber, Sarah K. Weirauch, Wolfgang W. Weisser, Dominik Ziaja, Jörg-Peter Schnitzler, J. Barbro Winkler, Caroline Müller   +23 more
doaj   +2 more sources

Diabetes distress is associated with adverse pregnancy outcomes in women with gestational diabetes: a prospective cohort study [PDF]

BMC Pregnancy and Childbirth, 2019
Background Around 12% of pregnant women develop gestational diabetes mellitus (GDM), which is associated with increased health risks for both mother and child and pre- and postpartum depression. Little is known about the relationship of GDM with diabetes-
Charlotte B. Schmidt, Ilse Voorhorst, Vital H. W. van de Gaar, Anne Keukens, Bert Jan Potter van Loon, Frank J. Snoek, Adriaan Honig   +6 more
doaj   +2 more sources

Countering unacceptable tax avoidance through general anti-avoidance rule in EU tax law [PDF]

Zbornik Radova Pravnog Fakulteta u Nišu, 2021
One of the greatest challenges modern states are faced with is finding a way to tackle unacceptable tax avoidance, especially aggressive tax planning schemes and the use of the so-called tax heavens.
Radić Irena
doaj   +1 more source

Gloss on the judgment of the Supreme Administrative Court in Warsaw of 22 August 2023, III FSK 354/23

Prawo Budżetowe Państwa i Samorządu, 2023
Nature of the gloss: partially approving. The gloss relates to a judgment of the Supreme Administrative Court covering the issue of the intertemporal provisions of the GAAR clause.
Oskar Bednarczyk, Patrycja Szkudlarek
doaj   +1 more source