Results 21 to 30 of about 1,145 (113)

A SELECTIVE AND SENSITIVE LC-MS/MS METHOD FOR QUANTIFICATION OF FOUR POTENTIAL GENOTOXIC IMPURITIES IN ATAZANAVIR SULFATE DRUG SUBSTANCE IN TRACE LEVEL

International Journal of Applied Pharmaceutics, 2021
Objective: The main objective of current research work is to develop and validate a rapid, sensitive and selective liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for the trace analysis of four potential genotoxic impurities in Atazanavir Sulfate drug substance. Methods: LC-MS/MS analysis of four potential genotoxic impurities ...
SIVA JYOTHI N., VENKATNARAYANA MUVVALA
openaire   +2 more sources

Advancing Antiviral Design: Integrating Natural Products, Computation and Targeted Delivery

Chemical Biology &Drug Design, Volume 108, Issue 1, July 2026.
A stepwise translational framework linking natural‐product discovery, computational prioritisation, experimental validation, lead optimisation and targeted delivery is proposed to advance antiviral design. ABSTRACT The COVID‐19 pandemic highlighted the role of rapid viral mutation and global connectivity in accelerating viral emergence and spread ...
Adedayo Ayodeji Lanrewaju, Abimbola Motunrayo Folami, Saheed Sabiu, Feroz Mahomed Swalaha   +3 more
wiley   +1 more source

Advancing Maternal Health with Long‐Acting Therapeutics: Priorities, Efficacy and Safety Considerations, and Emerging Technologies

Clinical Pharmacology &Therapeutics, Volume 119, Issue 5, Page 1179-1194, May 2026.
Maternal health remains a critical global concern, particularly in underserved populations and in low‐ and middle‐income countries where access to safe and effective therapeutics is limited. Despite the use of medications by most women during pregnancy, the exclusion of pregnant and lactating women from clinical trials has resulted in significant data ...
Rachel K. Scott, Sharon Nachman, Ethel D. Weld, Rachel Daley, Shakir Atoyebi, Robert Bies, Catriona Waitt, Adeniyi Olagunju   +7 more
wiley   +1 more source

The pharmacokinetics and safety of vonoprazan in adolescents and children with gastroesophageal reflux disease

Journal of Pediatric Gastroenterology and Nutrition, Volume 82, Issue 5, Page 1153-1161, May 2026.
Abstract Objectives Vonoprazan, a potassium‐competitive acid blocker, provides more rapid, potent, and durable elevations in gastric pH than proton pump inhibitors in adults and may be a treatment option for adolescents and children with gastroesophageal reflux disease (GERD).
Darcy J. Mulford, David A. Gremse, Yu‐Ming Chang, Eckhard Leifke, Thomas Wagner, Axel Facius, Galen Witt   +6 more
wiley   +1 more source

A Phase 1 Dose‐Escalation, Food Effect, and Drug–Drug Interaction Study Evaluating the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of the MALT1 Inhibitor, SGR‐1505, in Healthy Volunteers

Clinical Pharmacology in Drug Development, Volume 15, Issue 1, January 2026.
Abstract SGR‐1505 is a novel small‐molecule inhibitor of MALT1, a key mediator of NF‐κB signaling implicated in the pathogenesis of B‐cell malignancies. This study evaluated the safety, tolerability, pharmacokinetics, and pharmacodynamics of SGR‐1505 in healthy volunteers. In this four‐part, open‐label study, 73 participants received single or multiple
Vipul K. Gupta, Brian Yoo, Daniel Weiss, Frank G. Basile, Edgar Schuck, Christopher M. Rubino, Sen Zhang, Stephen E. Maxwell, Wenxin Zheng, Joanne B. L. Tan, David Stenehjem, Paul B. Watkins, Margaret Dugan, Wu Yin, D. Hamish Wright, Karen Akinsanya, Jason Lickliter   +16 more
wiley   +1 more source

Exposure the Hazardous Potential of Quinalphos: An In‐Depth Analysis for Environmental and Biological Effects on Human Health

IET Systems Biology, Volume 20, Issue 1, January/December 2026.
This study elucidates pesticide docking onto proteins encoded by differentially expressed genes, revealing interaction networks involving chemicals, genes, proteins, drugs and diseases. It highlights structural insights, regulatory pathways and potential therapeutic or environmental implications, providing a comprehensive understanding of the ...
Jyoti Kant Choudhari, Biju Prava Sahariah, Anand Kumar Jayapal, Jyotsna Choubey, Abhishek Tripathi   +4 more
wiley   +1 more source

Maternal Exposure to Medications and the Risk of Congenital and Early‐Onset Hearing Loss in Children: A Systematic Review and a Meta‐Analysis

Basic &Clinical Pharmacology &Toxicology, Volume 137, Issue 3, September 2025.
ABSTRACT Background Congenital hearing loss (CHL) affects approximately 1–2 in 1000 children and significantly impacts development. Exposure to medications during pregnancy may impact offspring hearing; however, the ototoxic effects of different drugs have not been systematically investigated.
Asli Sena Kücükyildiz, Mette Østergaard Thunbo, Christer Zøylner Swan, David P. Burgner, Jessica E. Miller, Therese Ovesen, Lars Henning Pedersen   +6 more
wiley   +1 more source

Ibrexafungerp: Mechanism of Action, Clinical, and Translational Science

Clinical and Translational Science, Volume 18, Issue 9, September 2025.
ABSTRACT Ibrexafungerp is a first‐in‐class triterpenoid antifungal that targets β‐(1,3)‐glucan synthase in fungal cell wall development. It is indicated for vulvovaginal candidiasis (VVC) and recurrent vulvovaginal candidiasis (RVVC) in adult and post‐menarchal pediatric females.
Adelynne H. Walley, Lauren N. Dupuis, Erica L. Woodahl, Shayna R. Killam   +3 more
wiley   +1 more source

Drug–drug interactions between gender‐affirming hormone therapy and antiretrovirals for treatment/prevention of HIV

British Journal of Clinical Pharmacology, Volume 90, Issue 10, Page 2366-2382, October 2024.
Transgender persons face a greater burden of HIV compared to cisgender counterparts. Concerns around drug–drug interactions (DDIs) have been cited as reasons for lower engagement in HIV care and lower pre‐exposure prophylaxis (PrEP) uptake among transgender populations.
Tessa Senneker
wiley   +1 more source

Enhancement of Solubility and Dissolution Rate of Atazanavir Sulfate by Nanocrystallization [PDF]

Indian Journal of Pharmaceutical Education and Research, 2021
Vedanshu Malviya, Prashant Burange, Yashdeepsingh Thakur, Mukund Tawar   +3 more
openaire   +1 more source