Results 21 to 30 of about 5,572 (72)

Urine‐Derived iPSC Neurospheres Uncover Proteomic Correlates of Clinical Severity in Dravet Syndrome

Journal of Neurochemistry, Volume 170, Issue 5, May 2026.
Urine epithelial cells from Dravet syndrome (DS) patients carrying distinct SCN1A variants were reprogrammed into induced pluripotent stem cells (iPSCs) and differentiated into neural stem cells (NSCs) to generate patient‐derived neurospheres. Three neurosphere lines were analyzed in biological triplicates using isobaric quantitative proteomics ...
Michele Martins, Guillaume Nugue, Andrey Aguiar, Leticia R. Q. Souza, Paulo V. Abrantes, Julia Rodrigues Trajano, Mariana Stelling, Magno Junqueira, Stevens Rehen, Marília Zaluar P. Guimarães   +9 more
wiley   +1 more source

Unraveling the role of TP53 mutations in myeloproliferative neoplasms: Molecular mechanisms of leukemic transformation

HemaSphere, Volume 10, Issue 3, March 2026.
Abstract TP53 mutations are found in over 50% of tumor types, including myeloproliferative neoplasms (MPNs). MPNs are characterized by a chronic phase, which may progress to secondary acute myeloid leukemia (sAML). Here, we discuss the physiological functions of p53 in hematopoiesis and its deregulation in MPNs.
Suzana da Silva‐Benedito, Paula Sabbo Bernardo, Jean‐Edouard Martin, Caroline Marty, Isabelle Plo, Iléana Antony‐Debré, Bárbara da Costa Reis Monte‐Mór   +6 more
wiley   +1 more source

Development and Psychometric Testing of the Breastfeeding Knowledge Scale (BKS) in Brazilian Healthcare Students

Journal of Evaluation in Clinical Practice, Volume 32, Issue 2, March 2026.
ABSTRACT Rationale Breastfeeding is recognized as a cornerstone of maternal and child health, yet health professionals frequently report insufficient knowledge to provide effective support. Strengthening the evaluation of educational outcomes in health professions training is therefore essential to improve clinical practice and patient care. This study
Patrícia Lima Pereira Peres, Rachele Simeon, Maria Helena do Nascimento Souza, Giovanni Galeoto, Thaís Emanuele da Conceição, Anna Berardi, Donatella Valente, Rosane Harter Griep   +7 more
wiley   +1 more source

Characterization of Complementary Feeding of Preterm Infants: Kangaroo Care Method Versus Conventional Care

Maternal &Child Nutrition, Volume 22, Issue 1, January 2026.
Complementary feeding (CF) in preterm infants (LBWI) has been discussed due to the need to balance the risks and benefits that permeate the age and quality of CF introduction. We conducted a cohort study in Brazil to compare CF among LBWI who participated or not in the Kangaroo Care Method. ABSTRACT In Brazil, the Kangaroo Care Method (KCM) is a public
Rejane Sousa Romão, Vivian Mara Gonçalves de Oliveira Azevedo, Rayany Cristina Souza, Eliziane Santos Medeiros, Priscilla Larissa Silva Pires, Leandro Alves Pereira, Ana Elisa Madalena Rinaldi   +6 more
wiley   +1 more source

Nurturing Care Systems Underlying Early Childhood Food Insecurity in Brazil: A Causal Loop Diagram Approach

Maternal &Child Nutrition, Volume 22, Issue 1, January 2026.
ABSTRACT Experiencing food insecurity in early childhood is associated with adverse health and nutrition outcomes. About 66% of Brazilian households with children are food insecure; however, interventions targeting early childhood have fallen short in addressing food insecurity due to a lack of funding and multisectoral coordination combined with the ...
Gabriela Buccini, Krystyna A. Stave, Katherine Marçal, Sonia Isoyama Venancio, Muriel Bauermann Gubert, Rafael Pérez‐Escamilla   +5 more
wiley   +1 more source

Use of DNA Methylation Profiling as a Molecular Classification Tool for Paediatric Central Nervous System Tumours: A Middle‐Income Country Population–Based Study

Neuropathology and Applied Neurobiology, Volume 51, Issue 5, October 2025.
ABSTRACT Paediatric central nervous system (CNS) tumours are the second most common childhood malignancy and the leading cause of cancer‐related mortality in this age group. Histopathological diagnosis can be challenging, particularly for rare or ambiguous tumours, and may result in misclassification.
Mayara F. Euzébio, Felipe L. T. Silva, Iva L. Hoffmann, Juliana S. Ruas, Larissa Akemi Kido, Dieila G. de Lima, Luciano Queiroz, Izilda A. Cardinalli, Ana Luiza Seidinger, Suelen Nascimento, Helder Tedeschi, Renato D. Puga, Priscila Pini Zenatti Sales, Patricia Y. Jotta, Mariana Maschietto   +14 more
wiley   +1 more source

Symptoms and Risk Factors for Long COVID: A Cross‐Sectional Study in Primary Care

Journal of Medical Virology, Volume 97, Issue 9, September 2025.
ABSTRACT This study aimed to determine the occurrence and risk factors for persistent symptoms after mild to moderate severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection in patients who presented in primary care during the 2021 pandemic.
Assel Muratovna Shigayeva Ferreira, Flávia Emília Leite de Lima Ferreira, Caio César Ferreira Alverga, João Agnaldo do Nascimento, André Luís Bonifácio de Carvalho, Gabriel Rodrigues Martins de Freitas, João Aurílio Cardoso de Moraes, Izabele da Silva Rocha, Lucas Tomaz da Silva, Beatriz Carolinny Pereira da Silva Alves, Cleidilaine Ramos de Oliveira, José Ricardo Araujo Cardoso, Ruth Maria Mendonça Anacleto, Leandro Pernambuco   +13 more
wiley   +1 more source

Comparative efficacy of selenoureido carbonic anhydrase inhibitors and azole antifungal drugs against clinical isolates of Malassezia pachydermatis

Veterinary Dermatology, Volume 36, Issue 3, Page 302-313, June 2025.
Background – Malassezia pachydermatis (MP) is implicated in severe dermatitis and otitis externa (OE) of companion animals and recently gained attention for its increasing resistance to azole compounds. For this reason, developing novel therapeutic strategies is of great interest. In a previous work, we used reference yeast isolates to evaluate several
Costanza Spadini, Nicolò Mezzasalma, Amienwanlen Eugene Odigie, Andrea Angeli, Fabrizio Carta, Silvia Selleri, Emanuele Gandolfo, Simone Taddei, Valentina Franceschi, Sergio Minesso, Claudiu T. Supuran, Clotilde Silvia Cabassi   +11 more
wiley   +1 more source

Biocultural Determinants of Mothers' Complementary Feeding Decisions in the Urban Brazilian Amazon

American Journal of Human Biology, Volume 37, Issue 5, May 2025.
ABSTRACT Objective Complementary feeding (CF) occurs during a critical period of infant growth and development with life‐long health implications. Despite international efforts, there remains significant variation in the adequacy of complementary diets across settings. In Brazil, there is marked variation in adherence to CF guidelines and infant growth
B. A. Piperata, S. F. Fannin, T. Cestonaro, A. C. Brito‐Azevedo, V. de Cássia Tavares da Silva, J. Mendonça Freire Pereira, R. Bittencourt Tavares Oliveira   +6 more
wiley   +1 more source

Relationship between vestibular alterations and cognitive performance in adults and older adults. [PDF]

Codas
Barreto TISS, d'Ávila JS, Mendonça SDS, Granzotti RBG, Comerlatto Junior AA, Duarte JL, Comerlatto MPDS, Panelli M, Mariotto LDF, Silva KD.   +9 more
europepmc   +1 more source