Results 11 to 20 of about 10,511 (95)

Inhibition of kynurenine 3‐monooxygenase (KMO) reduces fentanyl and sucrose intake and relapse‐like behaviour in rats

open access: yesBritish Journal of Pharmacology, Volume 183, Issue 18, Page 5458-5475, September 2026.
Abstract Background and Purpose Opioid use disorder, particularly involving fentanyl, poses major challenges due to high relapse rates and limited effectiveness of pharmacotherapies. The kynurenine pathway has emerged as a target for addiction treatment through its modulation of glutamatergic and dopaminergic neurotransmission.
Carlos Núñez‐de la Calle   +12 more
wiley   +1 more source

Supervised Exercise Intervention Restores Physical Activity and MultiOMIC‐Derived Frailty Biomarkers in Older Adults

open access: yesJournal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 4, August 2026.
ABSTRACT Background The molecular mechanisms underlying frailty are under intense investigation. Independent observational studies revealed various biological processes and biomarkers differentially expressed in frail individuals and after interventions.
Diego Marcos‐Perez   +10 more
wiley   +1 more source

Adaptation of the International Consortium for Health Outcomes Measurement Standard Set for Inflammatory Bowel Disease for Routine Collection in Clinical Practice

open access: yesJCC Plus, Volume 1, Issue 4, July 2026.
ABSTRACT Background and Aims Value‐based healthcare (VBHC) is based on evaluating clinical interventions according to their ability to improve outcomes and costs to finally enhance quality of care. As part of an initiative to introduce VBHC in inflammatory bowel disease (IBD), our project aimed to adapt the International Consortium for Health Outcomes ...
Xavier Calvet   +33 more
wiley   +1 more source

Home‐Based Versus In‐Hospital Care in Pediatrics: A Systematic Review of Cost‐Effectiveness Studies

open access: yesWorld Medical &Health Policy, Volume 18, Issue 2, June 2026.
ABSTRACT Home‐based care has emerged as a potential alternative to traditional hospital‐based care for children and adolescents worldwide. This systematic review aimed to systematically gather and critically assess the available evidence on the cost‐effectiveness of home‐based versus in‐hospital care for pediatric populations globally.
Luís Carlos Lopes‐Júnior   +8 more
wiley   +1 more source

Endocannabinoid system gene expression in mesocorticolimbic brain regions of individuals with alcohol use disorder: A descriptive study

open access: yesAddiction, Volume 121, Issue 5, Page 1179-1189, May 2026.
Abstract Aims To describe differences in the expression of genes encoding cannabinoid receptors (CNR1, CNR2), the associated receptor GRP55 and the enzymes fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MGLL) between individuals with alcohol use disorder (AUD) and controls in key mesocorticolimbic brain regions.
María Salud García‐Gutiérrez   +5 more
wiley   +1 more source

Analysis of Obesity Care in Spanish Healthcare Settings: OBEQUIDAD Study

open access: yesObesity Science &Practice, Volume 12, Issue 2, April 2026.
ABSTRACT Background Obesity management remains influenced by misconceptions about the disease, which compromise care quality. Introduction The OBEQUIDAD study explores the clinical management of people with obesity in Spain based on the perspectives of healthcare professionals involved in its treatment across different medical specialties.
Ana de Hollanda   +7 more
wiley   +1 more source

Universal Cytomegalovirus Screening in the First Trimester of Pregnancy: The Multicentre Observational Cohort Study in the Area of Barcelona (CITEMB Study)

open access: yesBJOG: An International Journal of Obstetrics &Gynaecology, Volume 133, Issue 5, Page 1037-1045, April 2026.
ABSTRACT Objective To determine the CMV seroprevalence among pregnant women and assess the rate of primary CMV infections during the first trimester. Design Prospective multicentre observational cohort study. Setting Four primary care centres (ASSIRs) and two tertiary hospitals in Barcelona and its metropolitan area. Pupulation or Sample Pregnant women
María Ángeles Sánchez‐Durán   +21 more
wiley   +1 more source

Communicative Justice in Later Life: A Critical Discourse Study and Bioethics‐of‐Vulnerability Analysis of Older Adults' Primary Care in Spain

open access: yesNursing Inquiry, Volume 33, Issue 2, April 2026.
ABSTRACT Older adults' experiences of primary care are shaped not only by service capacity but by the language and routines through which access and care are organised. Using a qualitative Critical Discourse Studies (CDS) approach informed by the bioethics of vulnerability, we analysed interviews and focus groups with 12 community‐dwelling older adults
Pablo Martínez‐Angulo   +1 more
wiley   +1 more source

Global Governance and Corruption in Healthcare: A Bibliometric Mapping of Policy Challenges and Global Research Trends

open access: yesWorld Medical &Health Policy, Volume 18, Issue 1, March 2026.
ABSTRACT This study aims to conduct a bibliometric analysis of scientific research related to the concept of corruption in the health sector worldwide, utilizing a scientific mapping method to compare the top 20 countries. The VOSviewer program was employed for bibliometric mapping.
Burhanettin Uysal
wiley   +1 more source

Impact of Socioeconomic Status on Dietary Intake in Adults Aged 60 and Over, in Northwestern Spain: A Study of Community‐Dwelling Older Adults Enrolled in a Municipal Active Aging Program

open access: yesGeriatrics &Gerontology International, Volume 26, Issue 3, March 2026.
We analyzed the impact of socioeconomic status on the diet of 192 older adults. Results reveal significant disparities in macronutrient intake, suggesting that health promotion strategies must consider the socioeconomic context to be effective. ABSTRACT Background Unhealthy lifestyles and poor dietary habits pose a major challenge to global public ...
Ana María Murillo‐Zaldívar   +6 more
wiley   +1 more source

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