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Real‐World Effectiveness and Safety of Saccharomyces boulardii CNCM I‐745 as Adjunct Therapy for Helicobacter pylori Eradication: Data From the European Registry on H. pylori Management (Hp‐EuReg)

Helicobacter, Volume 31, Issue 2, March/April 2026.
ABSTRACT Background Saccharomyces boulardii CNCM I‐745 (Sb) is one of the most widely used probiotics in clinical practice. The aim of this study was to assess the impact of adding Sb to Helicobacter pylori eradication therapy on treatment outcomes (effectiveness and safety) in routine European gastroenterology clinical practice.
Olga P. Nyssen +191 more
wiley +1 more source

Efficacy of a Multicomponent Intervention for Frailty or Physical Function in Prefrail or Frail Older Adults: FRAILMERIT Multicenter Clinical Trial

Journal of the American Geriatrics Society, Volume 74, Issue 3, Page 658-668, March 2026.
Clinical management of the older adult. ABSTRACT Objectives Frailty is a common condition in community‐dwelling older adults with high health and socioeconomic implications. However, primary care‐led randomized trials have been scarcely tested. Design Multicenter cluster randomized clinical trial.
Adriana Abizanda Saro +86 more
wiley +1 more source

Continuities in Policies and Turnover Among Actors: Instrument Constituencies in French Primary Care Reforms

European Policy Analysis, Volume 12, Issue 1, Winter 2026.
ABSTRACT Over the past decade, the concept of “instrument constituency” has been proposed as a way in which to bridge studies on policy networks and policy instruments. This concept focuses on policy networks composed of diverse actors who are brought together by the shared goal of promoting a specific instrument.
Noémie Morize
wiley +1 more source

Pleiotrophin/Midkine Pathway Is Dysregulated in a TDP‐43A315T Mouse Model of Amyotrophic Lateral Sclerosis (ALS)

Neuropathology, Volume 46, Issue 1, February 2026.
ABSTRACT Amyotrophic lateral sclerosis (ALS) is a fatal motor neuron disease (MND) characterized by progressive degeneration of both upper and lower motor neurons, along with skeletal muscles innervated by them. The identification of key molecules involved in disease pathology remains crucial for ALS, as no curative treatment is currently available ...
Paloma Martínez‐Alesón +3 more
wiley +1 more source

Nonsteroidal Anti‐Inflammatory Drugs and Risk of Gastrointestinal Bleeding: A Systematic Review and Meta‐Analysis

Clinical Pharmacology &Therapeutics, Volume 119, Issue 1, Page 46-62, January 2026.
Nonsteroidal anti‐inflammatory drugs (NSAIDs) are widely used for pain and inflammation but are associated with gastrointestinal (GI) bleeding. While this risk is well established, most studies evaluate NSAIDs as a homogenous class, limiting clinical decision‐making based on individual agent safety.
Abdelrahman G. Tawfik +7 more
wiley +1 more source

Long‐Term Effect of Macrolides on Helicobacter pylori Eradication: Data From the European Registry on Helicobacter pylori Management (Hp‐EuReg)

Helicobacter, Volume 31, Issue 1, January/February 2026.
ABSTRACT Background and Aims Previous antibiotic use influences Helicobacter pylori antibiotic resistance. This study evaluated how prior population‐level macrolide (especially clarithromycin) use affects H. pylori eradication success in naïve patients. Methods Retrospective, multicenter, ecological study. Multivariate logistic regression was performed
Olga P. Nyssen +177 more
wiley +1 more source

Social Determinants of Sepsis Mortality in the United States: A Retrospective, Epidemiologic Analysis

World Medical &Health Policy, Volume 17, Issue 4, Page 823-830, December 2025.
ABSTRACT Sepsis is a leading cause of mortality in the United States, with over 350,000 deaths annually, yet the contribution of neighborhood‐level social determinants of health (SDoH) remains underexplored. We conducted a retrospective analysis of 4.4 million hospitalized patients with sepsis, identified using ICD‐10 codes, leveraging de‐identified ...
Ahad Khaleghi Ardabili +3 more
wiley +1 more source

Disentangling eye movement desensitization and reprocessing mechanisms of action: The impact of eye movements in the eye blink conditioning task

Psychology and Psychotherapy: Theory, Research and Practice, Volume 98, Issue 4, Page 1005-1016, December 2025.
Abstract Objectives Eye movement desensitization and reprocessing (EMDR) is an effective evidence‐based treatment for post‐traumatic stress disorder. However, the therapeutic mechanisms underlying eye movements (EM) remain unclear. This study aimed to investigate the effect of horizontal EM on fear extinction learning in healthy individuals, using an ...
Daniel Folch‐Sanchez +8 more
wiley +1 more source

Epilepsia Open—August 2026 Announcements

Epilepsia Open, Volume 11, Issue 4, Page 1382-1383, August 2026.
wiley +1 more source

[Management by objectives and funding of primary care teams: Critical reflections]. [PDF]

Aten Primaria
Bayona-Huguet X, Fumàs-Coma À, Escosa-Farga À. +2 more
europepmc +1 more source

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