Results 161 to 170 of about 620,434 (340)

A Human Engineered Heart Tissue‐Derived Lipotoxic Diabetic Cardiomyopathy Model Revealed Early Benefits of Empagliflozin

Advanced Science, EarlyView.
This study develops a human engineered heart tissue‐derived model of diabetic cardiomyopathy that accurately replicates the dynamic changes in the structural, contractile, and electrophysiological properties of the myocardium. Furthermore, this model is used to confirm the direct protective effects of empagliflozin on the heart through an SGLT2 off ...
Lin Cai, Yuxin Zhao, Zilong Li, Liping Xiao, Yifan Wu, Shiya Wang, Qian Liu, Yida Ye, Yuxuan Guo, Donghui Zhang   +9 more
wiley   +1 more source

The Effect of a Cholesterol-Free Brain Fraction against Diet-Induced Atherosclerosis [PDF]

, 1953
Richard J. Jones, Sumner C. Kraft, S. Huffman, E. L. Balter, Robert B. Gordon   +4 more
openalex   +1 more source

Macrophage WEE1 Directly Binds to and Phosphorylates NF‐κB p65 Subunit to Induce Inflammatory Response and Drive Atherosclerosis

Advanced Science, EarlyView.
The present study shows that macrophage WEE1 drives NF‐κB activation and inflammatory atherosclerosis by directly phosphorylating p65 at S536. This finding illustrates a macrophage‐specific WEE1‐p65 axis in regulating inflammatory atherosclerosis and points out new directions to broaden the clinical applications for WEE1 inhibitors in atherosclerosis ...
Zhuqi Huang, Sirui Shen, Weixin Li, Mengyang Wang, Yudie Yang, Wu Luo, Xue Han, Zheng Xu, Julian Min, Xiaohong Long, Weijian Huang, Gaojun Wu, Yi Wang, Guang Liang   +13 more
wiley   +1 more source

The hydrophobic tunnel present in LOX-1 is essential for oxidized LDL recognition and binding

Journal of Lipid Research, 2009
Lectin-like oxidized LDL (ox-LDL) receptor-1 (LOX-1) is a type-II transmembrane protein that belongs to the C-type lectin family of molecules. LOX-1 acts as a cell surface endocytosis receptor and mediates the recognition and internalization of ox-LDL by
Omar L. Francone, Meihua Tu, Lori J. Royer, Jian Zhu, Kimberly Stevens, Joseph J. Oleynek, Zhiwu Lin, Lorraine Shelley, Thomas Sand, Yi Luo, Christopher D. Kane   +10 more
doaj  

Serum-cholesterol levels and atherosclerosis: effects of composition of diet and tri-iodothyronine on the rat [PDF]

, 1959
William Cuthbertson, P. V. Elcoate, Dennis Ireland, Daniel C. Mills, Patricia Shearley   +4 more
openalex   +1 more source

Non-invasive detection of endothelial dysfunction in children and adults at risk of atherosclerosis

The Lancet, 1992
D. Celermajer, K. Sørensen, V. Gooch, D. Spiegelhalter, O. Miller, I. Sullivan, J. Lloyd, J. Deanfield   +7 more
semanticscholar   +1 more source

Magnetite Micro/Nanorobots for Efficient Targeted Alleviation of Inflammatory Bowel Disease

Advanced Science, EarlyView.
Improved reactive oxygen species scavenging capacities of functionalized micro/nanorobots (MNRs) are useful for the treatment of inflammatory bowel disease (IBD). MNRs can break the harmful bacteria in IBD, thereby eliminating inflammation and restoring the intestinal barrier function.
Ying Feng, Yang Liu, Linlin Liu, Qian Yang, Miao An, Huaming Yang   +5 more
wiley   +1 more source

Serum Lipids and Atherosclerosis [PDF]

, 1953
Henry T. Ricketts
openalex   +1 more source

SUMOylation is a Translatable Target in Hypoxic MNPs Regulating Retinal Vasculopathy

Advanced Science, EarlyView.
During ischemic retinopathy/retinal vasculopathy, UBC9‐mediated SUMOylation in retinal macrophages enhances their pro‐angiogenic capacity via hypoxia‐induced SUMOylation of FUS at K327/K502. This modification suppresses FUS binding to the Vegfa mRNA 3’UTR, stabilizing transcripts and facilitating VEGFA production. Targeting UBC9 inhibition can serve as
Zheng Zhong, Guangyu Liang, Huimin Yu, Jiaqi Li, Ruohong Wang, Xiaohong Ma, Ziqing Zhou, Yin Zhao, Fei Sun, Xufang Sun   +9 more
wiley   +1 more source

Inflammation and Atherosclerosis

Circulation, 2002
P. Libby, P. Ridker, A. Maseri
semanticscholar   +1 more source