Results 191 to 200 of about 793,722 (339)

Molecular mechanisms and therapeutic progress in atherosclerosis: bridging immune inflammation and precision medicine. [PDF]

Front Immunol
Han Y, Xu H, Yao X, Li Z, Zhu C, Li X, Chen B, Sun H.   +7 more
europepmc   +1 more source

Macrophagic Sclerostin Loop2‐ApoER2 Interaction Required by Sclerostin for Cardiovascular Protective Action

Advanced Science, EarlyView.
Sclerostin loop2‐ApoER2 interaction in macrophages is required by sclerostin to suppress NF‐κB nuclear translocation and phosphorylation, to promote macrophage conversion into anti‐inflammatory subtypes in atherosclerotic aortas, as well as to prevent atherosclerosis and aortic aneurysm development in ApoE−/− mice. Abstract Therapeutic antibody against
Luyao Wang, Xiaohui Tao, Ning Zhang, Xin Yang, Hewen Jiang, Xiaofei Li, Shenghang Wang, Shijian Ding, Sifan Yu, Huarui Zhang, Yihao Zhang, Nanxi Li, Haitian Li, Zhanghao Li, Xiaoxin Wen, Meiheng Sun, Chuanxin Zhong, Jin Liu, Yuanyuan Yu, Xianghang Luo, Tao Zhang, Shu Zhang, Péter Ferdinandy, Yu Huang, Daqing Ma, Aiping Lu, Baoting Zhang, Ge Zhang   +27 more
wiley   +1 more source

Growth Differentiation Factor 15 as a Link Between Obesity, Subclinical Atherosclerosis, and Heart Failure: A Systematic Review. [PDF]

Medicina (Kaunas)
Alexa RE, Ceasovschih A, Morărașu BC, Asaftei A, Constantin M, Diaconu AD, Balta A, Haliga RE, Șorodoc V, Șorodoc L.   +9 more
europepmc   +1 more source

Effectiveness of Pre‐Transplant Dual GLP‐1 Receptor Agonist and SGLT2 Inhibitor Therapy on All‐Cause Mortality in Organ Transplantation Candidates with Obesity and Type 2 Diabetes: a Target‐Trial Emulation

Advanced Science, EarlyView.
This target trial emulation in solid organ transplant candidates with obesity and type 2 diabetes evaluates whether pre‐transplant dual therapy with GLP‐1 receptor agonists plus SGLT2 inhibitors is associated with post‐transplant mortality and kidney graft outcomes compared with monotherapy or usual care, using multinational electronic health records ...
Yu‐Nan Huang, Min‐Yu Tsou, Pin‐Hung Li, Jo‐Ching Chen, Yen‐Liang Liu, Gideon Meyerowitz‐Katz, Tsung‐Hsun Tsai, Pen‐Hua Su   +7 more
wiley   +1 more source

CD147/Basigin: From Integrative Molecular Hub to Translational Therapeutic Target

Advanced Science, EarlyView.
This review conceptualizes CD147 as a fundamental “Energy‐Structure Coupler,” physically bridging metabolic flux (via MCTs) with morphogenetic plasticity (via integrins/MMPs) to drive cancer, infection, and autoimmunity. Addressing the “specificity paradox” that limits current translation, the authors chart a strategic roadmap—spanning logic‐gated ...
Xiang‐Min Yang, Huijie Bian, Zhi‐Nan Chen   +2 more
wiley   +1 more source

Molecular mechanism for pancreatic β-cell dysfunction and atherosclerosis. [PDF]

Diabetol Int
Kaneto H.
europepmc   +1 more source

Chaperone‐Mediated Autophagic Degradation of USP9X in Macrophages Exacerbates Postmyocardial Infarction Inflammation and Cardiac Dysfunction

Advanced Science, EarlyView.
This study demonstrates that inflammatory stimuli induce the acetylation‐triggered, chaperone‐mediated autophagic degradation of ubiquitin‐specific peptidase 9 X‐linked (USP9X) in macrophages. USP9X acts as a macrophage “inflammation switch” after myocardial infarction (MI). USP9X loss destabilizes tumor necrosis factor receptor‐associated factor (TRAF)
Biqing Wang, Xiangheng Cai, Mengqi Li, Xue Liu, Junhui Xue, Ye Liu, Ding Ai, Xinyang Hu   +7 more
wiley   +1 more source

Differences and Compatibility between Human and Porcine Fibrinolytic Components toward Plasmin Generation and Fibrin Degradation

TH Open
Paul Y. Kim, Chengliang Wu, Hena Noorzada, Ali Aftabjahani   +3 more
doaj   +1 more source

Non-Coding RNA Profile in the Progression of Carotid Atherosclerosis: A Systematic Review. [PDF]

Int J Mol Sci
Sardelli G, Bufano P, Ragusa R, Laurino M, Masini G, Gargani L, Neglia D, De Caterina R, Caselli C.   +8 more
europepmc   +1 more source

Outward Remodeling of Coronary Arteries in Cardiac Allograft Vasculopathy Is Reduced Compared to Native Atherosclerosis [PDF]

, 2013
Dylan V. Miller, Charles German, Selby Oberton, Mónica P. Revelo, Josef Stehlik, E.M. Gilbert, Jose Nativí, Rami Alharethi, D. Budge, Melanie D. Everitt, Kimberly Molina, Stavros G. Drakos, M. Elizabeth H. Hammond, A.G. Kfoury   +13 more
openalex   +1 more source