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2017
In this chapter, we discuss the manner through which the immune system regulates the cardiovascular system in health and disease. We define the cardiovascular system and elements of atherosclerotic disease, the main focus in this chapter. Herein we elaborate on the disease process that can result in myocardial infarction (heart attack), ischaemic ...
Rahman, MS, Woollard, K
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In this chapter, we discuss the manner through which the immune system regulates the cardiovascular system in health and disease. We define the cardiovascular system and elements of atherosclerotic disease, the main focus in this chapter. Herein we elaborate on the disease process that can result in myocardial infarction (heart attack), ischaemic ...
Rahman, MS, Woollard, K
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Leukotrienes and Atherosclerosis
Current Drug Targets, 2010Evidence from experimental and genetic studies suggest the existence of a potential link between the leukotrienes (LT) signalling cascade, and the pathogenesis/progression of atherosclerosis and its serious consequences such as acute myocardial infarction (AMI), stroke, aortic aneurysms, and intimal hyperplasia.
G. Riccioni, M. Bäck, V. Capra
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Journal of Cardiovascular Pharmacology, 1984
The lesions of atherosclerosis are proliferative smooth-muscle lesions which may result from various forms of endothelial injury or dysfunction associated with the different risk factors for atherosclerosis. These lesions have been associated with interactions between platelets, macrophages, and with substances released from these cells, including ...
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The lesions of atherosclerosis are proliferative smooth-muscle lesions which may result from various forms of endothelial injury or dysfunction associated with the different risk factors for atherosclerosis. These lesions have been associated with interactions between platelets, macrophages, and with substances released from these cells, including ...
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Epigenetics and atherosclerosis
Biochimica et Biophysica Acta (BBA) - General Subjects, 2009The contribution of epigenetic mechanisms to cardiovascular diseases remains poorly understood. Hypomethylation of genomic DNA is present in human atherosclerotic lesions and methylation changes also occur at the promoter level of several genes involved in the pathogenesis of atherosclerosis, such as extracellular superoxide dismutase, estrogen ...
Mikko P, Turunen +2 more
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Atherosclerosis, biomarkers of atherosclerosis and Alzheimer's disease
International Journal of Neuroscience, 2013Alzheimer's disease (AD) is the most prevalent type of dementia, involving progressive deterioration of neuronal networks. Although the pathophysiological mechanism of AD is not fully elucidated, apart from β-amyloid and tau protein, a diverse number of factors such as cardiovascular risk factors, inflammation, and lipids metabolism may play a ...
Aidonio, Fiolaki +5 more
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Atherosclerosis, 2000
Epidemiological studies have demonstrated a correlation between environmental or occupational arsenic exposure and a risk of vascular diseases related to atherosclerosis. Studies summarized in this review suggest that arsenic induces endothelial dysfunction, including inflammatory and coagulating activity as well as impairs nitric oxide (NO) balance ...
Petia P, Simeonova, Michael I, Luster
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Epidemiological studies have demonstrated a correlation between environmental or occupational arsenic exposure and a risk of vascular diseases related to atherosclerosis. Studies summarized in this review suggest that arsenic induces endothelial dysfunction, including inflammatory and coagulating activity as well as impairs nitric oxide (NO) balance ...
Petia P, Simeonova, Michael I, Luster
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Current Atherosclerosis Reports, 2008
Atherothrombosis is the underlying cause of several clinical manifestations, such as acute coronary syndromes, cerebrovascular disease, and peripheral artery disease, which together are the leading cause of death in the Western world. Proteins from vascular cells or atherosclerotic plaques that are present in plasma are modified along the different ...
Roxana, Martinez-Pinna +5 more
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Atherothrombosis is the underlying cause of several clinical manifestations, such as acute coronary syndromes, cerebrovascular disease, and peripheral artery disease, which together are the leading cause of death in the Western world. Proteins from vascular cells or atherosclerotic plaques that are present in plasma are modified along the different ...
Roxana, Martinez-Pinna +5 more
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Hypertension and Atherosclerosis
Journal of Cardiovascular Pharmacology, 1990Membrane phospholipase C (PLC) activation is induced by the interaction of numerous vasoactive hormones and growth factors with their receptors. Two products are liberated: inositol triphosphate (IP3) and diacyglycerol (DG). The first product liberates intracellular calcium from its stores in the sarcoplasmic reticulum and the second one activates a ...
M, Baudouin-Legros, P, Meyer
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Forensic Science International, 1995
A cohort of alcoholics who underwent a medico-legal autopsy during a 5-year period was compared with non-alcoholic controls who did not differ from the alcoholics in selection criteria. The degree of atherosclerosis in the coronary arteries and the aorta was examined.
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A cohort of alcoholics who underwent a medico-legal autopsy during a 5-year period was compared with non-alcoholic controls who did not differ from the alcoholics in selection criteria. The degree of atherosclerosis in the coronary arteries and the aorta was examined.
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THROMBOSIS AND ATHEROSCLEROSIS
British Medical Bulletin, 1978From the clinical point of view the most important end results of atherosclerosis are stenosis and occlusion of the affected artery. A prerequisite for this is a degree of plaque growth sufficient to encroach significantly on the integrity of the vessel lumen.
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