Results 331 to 340 of about 999,481 (385)

Advancements in dual-targeting nanoparticle strategies for enhanced atherosclerosis therapy: Overcoming limitations of single-targeting approaches. [PDF]

Bioact Mater
Yang C, Mo L, Zhang G, Dai Y, Li B, Tan Z, Guo Y, Lu S, Hong Y, He H, Yang H, He J.   +11 more
europepmc   +1 more source

The Aging Gut–Brain Axis: Effects of Dietary Polyphenols and Metal Exposure

Chronic Diseases and Translational Medicine, EarlyView.
The influence of gut microbiota on brain health ABSTRACT Diet provides essential metals, which are required for the growth, development, and well‐functioning of the body. Nonetheless, some natural and human activities add toxic heavy metals to the diet, consequently introducing them to our bodies, resulting in several disorders and death. The intestine,
Luqi Cao, Saurabh Kumar Jha, Neha Gupta, Xiang Chen, Renuka Soni, Luoxi Yuan, Rashi Srivastava, Zhe‐Sheng Chen   +7 more
wiley   +1 more source

Nanogel‐Mediated Immunotherapy to Tackle Cancer and Inflammatory Diseases

ChemistryEurope, EarlyView.
Nanogels formed through self‐assembly, microemulsion, or precipitation polymerization method enable precise delivery of immunotherapeutic factors and immune cell targeting, thus effectively modulating immune responses. This review highlights recent advances in stimuli‐responsive nanogel design, underlying mechanisms, and their potentials to tackle ...
Ziwen Zhang, Jinxia Wang, Guang‐Zhi Jin, István Bányai, Dzmitry Shcharbin, Ivan Stoikov, Mingwu Shen, Xiangyang Shi   +7 more
wiley   +1 more source

Influence of LDL cholesterol and Lp(a) on monocytes and macrophages in atherosclerosis. [PDF]

Biochem Med (Zagreb)
Ugovšek S, Jeras J, Šebeštjen M, Zupan J.   +3 more
europepmc   +1 more source

Nanomaterial‐Based Precision Medicine for Breast Cancer Diagnosis and Treatment

ChemNanoMat, EarlyView.
This research emphasizes the use of targeted precision medicine in the treatment of breast cancer. Through the integration of diagnosis and therapeutic delivery, nanocarriers are designed to selectively target cancer cells, preserving healthy tissue, thereby improving treatment effectiveness and reducing side effects.
Tanaka Ndongwe, Xavier Siwe Noundou, Gauta Gold Matlou, Stéphanie Bessoles, Johanne Seguin, Cyrille Richard, Nathalie Mignet, Yohann Corvis, Bwalya Angel Witika   +8 more
wiley   +1 more source

Carotid artery atherosclerosis, MRI-defined structural brain abnormalities, and cognitive performance in elderly American Indians: The Strong Heart Study. [PDF]

Front Epidemiol
Ali T, Buchwald D, Shibata D, Roman MJ, Verney S, Howard BV, Umans J, Cole S, West C, Zhang Y, Reese J, Rhoades DA, O'Leary M, Longstreth WT, Fretts A, Suchy-Dicey A.   +15 more
europepmc   +1 more source

Anti-JNK2 peptide–siRNA nanostructures improve plaque endothelium and reduce thrombotic risk in atherosclerotic mice [PDF]

, 2018
Akk, Antonina, Bacon, John, Hou, Kirk K, Miller, Mark J, Palekar, Rohun U, Pan, Hua, Pham, Christine T.N, Schlesinger, Paul H, Springer, Luke E, Wickline, Samuel A, Yan, Huimin, Yang, Lihua   +11 more
core   +1 more source

Effectiveness and Safety of Reduced‐Dose Prasugrel in an East Asian Population: PRASFIT‐ACS Emulation Using National Health Insurance Claims Data

Clinical Pharmacology &Therapeutics, EarlyView.
Prasugrel is recommended for acute coronary syndrome (ACS) patients undergoing percutaneous coronary intervention (PCI). However, East Asians exhibit a stronger antiplatelet response, raising concerns about bleeding risks with standard dosing. This retrospective cohort study evaluated the real‐world effectiveness and safety of reduced‐dose prasugrel in
Li‐Wen Huang, Yee‐Jen Wu, Fang‐Ju Lin, Chien‐Chih Wu, Hsin‐Yi Huang, Chi‐Chuan Wang, Xiaojuan Li   +6 more
wiley   +1 more source

Plasma proteomic and metabolomic profiling of coronary and carotid atherosclerosis in the SCAPIS study-differences and similarities. [PDF]

Cardiovasc Res
Fall T, Gummesson A, Hammar U, Ahlström H, Angerås O, Blomberg A, Brandberg J, Caidahl K, Chorell E, Engvall JE, Eriksson P, Erlinge D, Gigante B, Hjelmgren O, Hultdin J, Jernberg T, Kihlberg J, Lind L, Magnusson M, Nyström FH, Pirazzi C, Schiopu A, Sundström J, Söderberg S, Östgren CJ, Engström G.   +25 more
europepmc   +1 more source

Clinical Trials With Pragmatic Elements: A Review of Use Cases and Real‐World Data Utilization

Clinical Pharmacology &Therapeutics, EarlyView.
Clinical trials with pragmatic elements can capture diverse patient populations, enable efficient follow‐up, and reflect routine clinical practices; yet there is limited understanding of their design features, characteristics, and use of real‐world data (RWD). Based on a targeted search of PubMed/EMBASE (Jan‐2016 to Jul‐2024), a review was conducted to
Le Su, Lei Chen, Seema Betigeri, Nancy Dreyer, Helga Gardarsdottir, Rachele Hendricks‐Sturrup, Mehmet Burcu   +6 more
wiley   +1 more source