Results 141 to 150 of about 510,672 (398)

Astrocytic ET‐1 System Determines Microglia Phenotype Following Spinal Cord Injury

Advanced Science, EarlyView.
The study reveals that astrocytic ET‐1 system is solely activated by thrombin following SCI via RhoA/NF‐κB and MAPKs/NF‐κB signal pathway. The release of astrocytic ET‐1 drives microglia polarization toward M1 phenotype through YAP signaling via ETA and ETB receptors.
Bingqiang He, Si Xu, Mengdi Li, Hui Li, Shaolan Li, Li Niu, Honghua Song, Rixin Cai, Yue Zhou, Zhilong Cao, Yingjie Wang, Yongjun Wang   +11 more
wiley   +1 more source

MO‐hHHO: Multi‐Objective Hybrid Harris Hawks Optimization for Prediction of Coronary Artery Disease

Advanced Intelligent Systems, EarlyView.
This article proposes a novel Multi‐Objective hybrid Harris Hawks Optimization (MO‐hHHO) algorithm for simultaneous feature selection and hyperparameter tuning in heart disease classification. The approach leverages adaptive exploration‐exploitation strategies to enhance convergence efficiency.
Anu Ragavi Vijayaraj, Subbulakshmi Pasupathi   +1 more
wiley   +1 more source

Integration of Cholesterol Oxidase‐Based Biosensors on a Smart Contact Lens for Wireless Cholesterol Monitoring from Tears

Advanced Intelligent Systems, EarlyView.
The combination of a parity‐time symmetry wireless technology with a cholesterol sensor integrated into a smart contact lens enables high‐sensitivity cholesterol sensing at low concentration. Cholesterol plays a critical role in physiological functions, but elevated levels increase the risk of cardiovascular disease.
Yang Cui, Lin Zhuo, Yuta Nishina, Saman Azhari, Takeo Miyake   +4 more
wiley   +1 more source

Harnessing Physiological Shear Stress in a Perfusion Bioreactor for Enhanced Endothelialization of Small‐Diameter Vascular Grafts

Advanced NanoBiomed Research, EarlyView.
Traditional static culture provides limited physiological relevance for evaluation of vascular grafts. A perfusion bioreactor system can provide more accurate in vitro model for evaluation of vascular grafts, exposing endothelial cells on 3D structure to physiological or pathological shear stress.
Praveesuda L. Michael, Yuen Ting Lam, Timothy C. Mitchell, Miguel Santos, Alex H. P. Chan, Xinying Liu, Angus J. Grant, Matthew J. Moore, David F. Fletcher, Richard P. Tan, Steven G. Wise   +10 more
wiley   +1 more source

Macrophage autophagy in atherosclerosis [PDF]

, 2013
Macrophages play crucial roles in atherosclerotic immune responses. Recent investigation into macrophage autophagy (AP) in atherosclerosis has demonstrated a novel pathway through which these cells contribute to vascular inflammation.
Carnuccio, R., Grassia, G., Ialenti, A., Maffia, P., Maiuri, M.C., Platt, A.   +5 more
core   +2 more sources

Inhibiting macrophage proliferation suppresses atherosclerotic plaque inflammation

Science Advances, 2015
Nanoparticle-based delivery of simvastatin inhibits plaque macrophage proliferation in apolipoprotein E–deficient mice. Inflammation drives atherosclerotic plaque progression and rupture, and is a compelling therapeutic target.
Jun Tang, M. Lobatto, Laurien T Hassing, Susanne E M van der Staay, Sarian M. van Rijs, C. Calcagno, Mounia S. Braza, Samantha Baxter, F. Fay, Brenda L. Sánchez-Gaytán, R. Duivenvoorden, H. Sager, Yaritzy M. Astudillo, W. Leong, S. Ramachandran, G. Storm, C. Pérez-Medina, T. Reiner, D. Cormode, G. Strijkers, E. Stroes, F. Swirski, M. Nahrendorf, E. Fisher, Z. Fayad, W. Mulder   +25 more
semanticscholar   +1 more source

High shear stress induces atherosclerotic vulnerable plaque formation through angiogenesis

Regenerative Biomaterials, 2016
Rupture of atherosclerotic plaques causing thrombosis is the main cause of acute coronary syndrome and ischemic strokes. Inhibition of thrombosis is one of the important tasks developing biomedical materials such as intravascular stents and vascular ...
Yi Wang, J. Qiu, Shisui Luo, Xiang Xie, Yiming Zheng, Kang Zhang, Z. Ye, Wanqian Liu, H. Gregersen, Guixue Wang   +9 more
semanticscholar   +1 more source

Extracellular Vesicles in Calcium Oxalate Nephrolithiasis: Emerging Biomarkers and Therapeutic Potential

Advanced NanoBiomed Research, EarlyView.
Kidney stones cause significant pain and healthcare costs. Current prediction, diagnosis, and treatment options are limited. Extracellular vesicles (EVs), rich in proteins, lipids, and nucleic acids, offer a promising solution. This review explores the roles of EVs in kidney stone management, highlighting their potential as biomarkers and therapeutic ...
Wang Zhu, Xu Changzhi, Deng Qiong, Liang Hui   +3 more
wiley   +1 more source

CT attenuation analysis of carotid intraplaque hemorrhage [PDF]

, 2018
Background and Purpose: Intraplaque hemorrhage is considered a leading parameter of carotid plaque vulnerability. Our purpose was to assess the CT characteristics of intraplaque hemorrhage with histopathologic correlation to identify features that allow ...
Bassareo, P. P., Cecco, C. N. D., Faa, X. G., Francone, M., Lai, L., Montisci, R., Saba, L., Sanfilippo, Rosa, Suri, J. S.   +8 more
core   +1 more source

Serotonergic Modulators in Alzheimer's Disease: A Hope in the Hopeless Condition

Chemistry &Biodiversity, EarlyView.
ABSTRACT Alzheimer's disease (AD) is the main cause of dementia worldwide. AD is a progressive brain neurodegenerative disease due to genetic and environmental factors that induce a progressive accumulation of intracellular hyperphosphorylated tau protein and extracellular amyloid protein (Aβ).
Najlaa Hamed Almohmadi, Hayder M. Al‐Kuraishy, Ali I. Al‐Gareeb, Ali K. Albuhadily, Morkoss M. Fakhry, Athanasios Alexiou, Marios Papadakis, Gaber El‐Saber Batiha   +7 more
wiley   +1 more source