Results 311 to 320 of about 118,937 (337)
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2009
Even though coronary, cerebral, and peripheral arterial disease represents the most common features of atherosclerosis, it progresses in the absence of any symptoms for most of its developmental course. Generally, the severity of a coronary stenosis is of poor predictive value for cardiac events such as sudden death, myocardial infarction, or unstable ...
Massimo Fioranelli +2 more
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Even though coronary, cerebral, and peripheral arterial disease represents the most common features of atherosclerosis, it progresses in the absence of any symptoms for most of its developmental course. Generally, the severity of a coronary stenosis is of poor predictive value for cardiac events such as sudden death, myocardial infarction, or unstable ...
Massimo Fioranelli +2 more
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Taking AIM2 at atherosclerotic plaques
Nature Reviews Drug Discovery, 2021Clonal haematopoiesis — an expansion of blood cell clones due to advantageous somatic mutations — is linked to myocardial infarction. A new study shows that activation of the AIM2 inflammasome in clonally expanded macrophages exacerbates atherosclerosis by driving both proliferation and pyroptosis.
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Development of atherosclerotic plaques
Acta Medica Scandinavica, 1985ABSTRACT. Atherosclerosis is a multifactorial disease. A unified model for the lesion development reveals many connections between the response‐to‐injury hypothesis and the lipid hypothesis. Various cellular uptake mechanisms for native and modified lipoproteins are discussed with respect to foam cell formation and lesion development.
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Apoptosis in human atherosclerotic plaques
Apoptosis, 1999Intimal cell death has been a recognized feature of advanced atherosclerotic disease. With the advent of DNA in situ end labelling and/or ultrastructural techniques, recent findings suggest that cells of an atheroma undergo programmed cell death or apoptosis. The pathophysiologic relevance of apoptosis in atherosclerotic disease is debatable. Apoptotic
Renu Virmani +3 more
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Agents that stabilise atherosclerotic plaque
Expert Opinion on Investigational Drugs, 2003The concept of plaque stabilisation was developed to explain how medications could decrease adverse coronary events without a substantial reduction in the regression of atherosclerosis. With this concept, a comprehensive view of atherosclerosis is now appreciated.
Jun R Chiong, Alan B Miller
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2015
Over the past decade, significant strides have been made in advanced non-invasive cardiac imaging. Technological advances in both hardware and software applications have made direct visualization of atherosclerotic plaque a reality. These advances have come at a crucial time, and help to fill a gap in contemporary diagnostic modalities, which have ...
P. Singh, A. Tawakol
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Over the past decade, significant strides have been made in advanced non-invasive cardiac imaging. Technological advances in both hardware and software applications have made direct visualization of atherosclerotic plaque a reality. These advances have come at a crucial time, and help to fill a gap in contemporary diagnostic modalities, which have ...
P. Singh, A. Tawakol
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MR imaging of atherosclerotic plaque
Radiologic Clinics of North America, 2002MRI is a powerful noninvasive imaging tool with high spatial resolution that continues to prove its value in determining atherosclerotic plaque size, volume, and tissue components. Multispectral MRI sequences have been validated to characterize atherosclerotic plaque components in animals; they have recently been applied to human aorta and carotid ...
Christopher M. Kramer, C. Joon Choi
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Is regression of atherosclerotic plaque possible?
Clínica e Investigación en Arteriosclerosis (English Edition), 2017As it is well-known, a thrombus evolving into a disrupted/eroded atherosclerotic plaque causes most acute coronary syndromes. Plaque stabilization via reduction of the lipid core and/or thickening of the fibrous cap is one of the possible mechanisms accounted for the clinical benefits displayed by different anti-atherosclerotic strategies.
José A. Páramo, Fernando Civeira
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Atherosclerotic plaque assessment by NMR
Magnetic Resonance Materials in Physics, Biology and Medicine, 1998Developing imaging technologies capable of identifying unstable atheromatous plaques in vivo is a major issue of clinical cardiovascular research. These techniques would allow an earlier surgical or medical therapy before acute ischemic syndromes [1]. Plaque stability and its counterpart i.e.
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Impact of Statins on Atherosclerotic Plaque
Future Cardiology, 2007Lowering levels of low-density lipoprotein cholesterol with inhibitors of 3-hydroxy-methylglutaryl coenzyme A reductase (statins) has a profound impact on cardiovascular event rates. The degree of benefit is proportional to the extent of low-density lipoprotein cholesterol lowering achieved. In addition to lowering levels of atherogenic lipids, statins
Adnan K. Chhatriwalla +2 more
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