Results 31 to 40 of about 42,048 (220)

Interaction of perforin and granzyme B and HTLV-1 viral factors is associated with ATL development [PDF]

Iranian Journal of Basic Medical Sciences, 2020
Objective(s): Human T cell leukaemia virus type 1 (HTLV-1) is associated with adult T cell leukaemia (ATL), a malignant lymphoproliferative disease that infects CD4 T cells.
Mohammad Mehdi Akbarin, Sadegh Farhadi, Abolghasem Allahyari, Mohammad Mehdi Koshayar, Abbas Shirdel, Hossain Rahimi, Abdolrahim Rezaee, Maryam Mahdifar, Zahra Mozaheb, Asadollah Mohamadi, Alireza Bari, Seyedeh Tahereh Mohaddes, Houshang Rafatpanah   +12 more
doaj   +1 more source

Targeted zinc-finger repressors to the oncogenic HBZ gene inhibit adult T-cell leukemia (ATL) proliferation

, 2023
Human T-lymphotropic virus type I (HTLV-I) infects CD4+ T-cells resulting in a latent, life-long infection in patients. Crosstalk between oncogenic viral factors results in the transformation of the host cell into an aggressive cancer, adult T-cell ...
Scott, TA, Scott, Tristan A, Morris, Kevin V, Ray, RM, Soemardy, Citradewi, Soemardy, C, Morris, KV, Ray, Roslyn M   +7 more
core   +1 more source

ATL2 Recruits TRAK1 to Promote Mitochondrial Transport at ER–Mitochondria Contact Sites

Advanced Science, EarlyView.
ABSTRACT Mitochondrial transport and distribution are crucial for cellular homeostasis, yet whether and how they are regulated by endoplasmic reticulum (ER)–mitochondria contact sites remains unclear. Here, we demonstrate that the ER protein atlastin‐2 (ATL2) orchestrates mitochondrial transport and distribution by promoting assembly of the transport ...
Yiru Cheng, Peiyuan Chai, Xiayuhe Pei, Yiwen Chen, Xiaoshuai Huang, Bei Liu, Yiqian Wu, Junlin Teng, Pengli Zheng, Jianguo Chen   +9 more
wiley   +1 more source

Controversies in Targeted Therapy of Adult T Cell Leukemia/Lymphoma: ON Target or OFF Target Effects?

Viruses, 2011
Adult T cell leukemia/lymphoma (ATL) represents an ideal model for targeted therapy because of intrinsic chemo-resistance of ATL cells and the presence of two well identified targets: the HTLV-I retrovirus and the viral oncoprotein Tax.
Hugues de Thé, Rihab Nasr, Ali Bazarbachi, Olivier Hermine, Youmna Kfoury, Hiba El Hajj   +5 more
doaj   +1 more source

The accuracy of the Montenegro skin test for leishmaniasis in PCR-negative patients

Revista da Sociedade Brasileira de Medicina Tropical, 2020
INTRODUCTION: As highly specific molecular biology-based techniques may not be sensitive enough for the diagnosis of American tegumentary leishmaniasis (ATL), clinicians frequently rely on immunological tests before treatment initiation.
Ana Bárbara Sapienza Pinheiro, Patricia Shu Kurizky, Marina de Freitas Ferreira, Marco Antonio de Souza Mota, Jaqueline Santos Ribeiro, Edson Zuza de Oliveira Filho, Carlos Augusto Souza, Daniel Holanda Barroso, Raimunda Nonata Ribeiro Sampaio, Ciro Martins Gomes   +9 more
doaj   +1 more source

Low‐Voltage Operation of IGZO Memtransistors Enabled by Coupling Enhancement Through 2T Drain‐Driven Operation for Neuromorphic Computing

Advanced Intelligent Systems, EarlyView.
A two‐terminal IGZO memtransistor enabling low‐voltage operation is demonstrated through coupling enhancement. By utilizing drain‐induced Fowler–Nordheim tunneling, the device achieves programming below 10 V with a large memory window and high on/off ratio.
Junhyeong Park, Sunyeol Bae, Yumin Yun, Chae‐Hwan Park, Donghyeon Lee, Soo‐Yeon Lee   +5 more
wiley   +1 more source

Drosophila Atlastin regulates synaptic vesicle mobilization independent of bone morphogenetic protein signaling

Biological Research, 2023
Background The endoplasmic reticulum (ER) contacts endosomes in all parts of a motor neuron, including the axon and presynaptic terminal, to move structural proteins, proteins that send signals, and lipids over long distances.
Francisca Bertin, Jorge Jara-Wilde, Benedikt Auer, Andrés Köhler-Solís, Carolina González-Silva, Ulrich Thomas, Jimena Sierralta   +6 more
doaj   +1 more source

Synergistic effects of HDAC inhibitor tucidinostat and ENT inhibitor dipyridamole in T-cell malignancies

Scientific Reports
Achieving both selectivity and cytotoxicity against cancer cells remains a major challenge in cancer therapy. Histone deacetylase (HDAC) inhibitors, such as tucidinostat, suppress tumor growth by epigenetically regulating tumor suppressor gene expression
Jiazhou Li, Ahmed E. Goda, Daniel Enriquez-Vera, Shuhei Fujii, Satomi Harazono, Jhajaira M. Araujo, Nao Nishikoba, Sophia Velarde, Atakan Zeki Namli, Alvaro De Jesus Huamani Ortiz, Shingo Nakahata   +10 more
doaj   +1 more source

Alternating-time temporal logic with finite-memory strategies [PDF]

Electronic Proceedings in Theoretical Computer Science, 2013
Model-checking the alternating-time temporal logics ATL and ATL* with incomplete information is undecidable for perfect recall semantics. However, when restricting to memoryless strategies the model-checking problem becomes decidable.
Steen Vester
doaj   +1 more source

JAG1 overexpression contributes to Notch1 signaling and the migration of HTLV-1-transformed ATL cells

Journal of Hematology & Oncology, 2018
Background HTLV-1 is a retrovirus that infects over 20 million people worldwide and is responsible for the hematopoietic malignancy adult T cell leukemia (ATL). We previously demonstrated that Notch is constitutively activated in ATL cells.
Marcia Bellon, Ramona Moles, Hassiba Chaib-Mezrag, Joanna Pancewicz, Christophe Nicot   +4 more
doaj   +1 more source