Results 21 to 30 of about 892,504 (360)

Short-Term Efficacy of Using a Novel Low-Volume Bone Marrow Aspiration Technique to Treat Knee Osteoarthritis: A Retrospective Cohort Study

Stem Cells International, 2022
Background. Intra-articular bone marrow concentrate (BMC) and aspirate (BMA) injections have been used with mixed results to treat osteoarthritis (OA). Given the various aspiration and concentration methods available for preparing bone marrow, more data ...
Daniel Kuebler, Alexandra Schnee, Lisa Moore, Jason Kouri, Alexis McLaughlin, Robert Hanson, Patrick Kuebler, Ignacio Dallo, Alberto Gobbi   +8 more
doaj   +1 more source

A DNA methylation atlas of normal human cell types

Nature, 2023
DNA methylation is a fundamental epigenetic mark that governs gene expression and chromatin organization, thus providing a window into cellular identity and developmental processes^ 1 .
Netanel Loyfer, J. Magenheim, A. Peretz, G. Cann, J. Bredno, A. Klochendler, Ilana Fox-Fisher, Sapir Shabi-Porat, M. Hecht, Tsuria Pelet, J. Moss, Zeina Drawshy, Hamed Amini, P. Moradi, Sudharani Nagaraju, D. Bauman, D. Shveiky, S. Porat, U. Dior, G. Rivkin, O. Or, N. Hirshoren, E. Carmon, A. Pikarsky, A. Khalaileh, G. Zamir, R. Grinbaum, Machmud Abu Gazala, I. Mizrahi, N. Shussman, A. Korach, O. Wald, U. Izhar, E. Erez, V. Yutkin, Yaacov Samet, Devorah Rotnemer Golinkin, K. Spalding, H. Druid, P. Arner, A. Shapiro, M. Grompe, Alex Aravanis, O. Venn, A. Jamshidi, R. Shemer, Y. Dor, Benjamin Glaser, Tommy Kaplan   +48 more
semanticscholar   +1 more source

Spatiotemporal transcriptomic atlas of mouse organogenesis using DNA nanoball patterned arrays

bioRxiv, 2021
Spatially resolved transcriptomic technologies are promising tools to study cell fate decisions in a physical microenvironment, which is fundamental for enhancing our knowledge of mammalian development.
Ao Chen, Sha Liao, Mengnan Cheng, Kailong Ma, Liang Wu, Yiwei Lai, Xiaojie Qiu, Jin Yang, Wenjia Li, Jiangshan Xu, Shijie Hao, Xin Wang, Huifang Lu, Xi Chen, Xingmin Liu, Xin Huang, Feng Lin, Zhao-Peng Li, Yanping Hong, Defeng Fu, Yujia Jiang, Jian Peng, Shuai Liu, Mengzhe Shen, Chuanyu Liu, Quan-Zhen Li, Yue Yuan, Hui-chao Zheng, Zhifeng Wang, Zhaohui Wang, Haitao Xiang, Lei Han, Baoming Qin, Pengcheng Guo, Pura Muñoz- Cánoves, J. Thiery, Qingfeng Wu, Fuxiang Zhao, Mei Li, Haoyan Kuang, Junhou Hui, Ou Wang, Haorong Lu, Bo Wang, Shiping Liu, Ming Ni, Wenwei Zhang, Feng Mu, Ye Yin, Huanming Yang, M. Lisby, R. Cornall, J. Mulder, M. Uhlén, M. Esteban, Yuxiang Li, Longqi Liu, Xun Xu, Jian Wang   +58 more
semanticscholar   +1 more source

A single-cell and spatially resolved atlas of human breast cancers

Nature Genetics, 2021
Breast cancers are complex cellular ecosystems where heterotypic interactions play central roles in disease progression and response to therapy. However, our knowledge of their cellular composition and organization is limited.
Sunny Z. Wu, G. Al-Eryani, D. Roden, S. Junankar, K. Harvey, Alma Andersson, A. Thennavan, Chenfei Wang, J. Torpy, N. Bartonicek, Taopeng Wang, L. Larsson, D. Kaczorowski, N. Weisenfeld, C. Uytingco, J. Chew, Zachary W. Bent, Chia-Ling Chan, Vikkitharan Gnanasambandapillai, C. Dutertre, L. Gluch, M. Hui, J. Beith, A. Parker, E. Robbins, D. Segara, C. Cooper, C. Mak, B. Chan, S. Warrier, F. Ginhoux, Ewan K. A. Millar, J. Powell, Stephen R. Williams, X. Liu, S. O'toole, E. Lim, J. Lundeberg, C. Perou, A. Swarbrick   +39 more
semanticscholar   +1 more source

An atlas of substrate specificities for the human serine/threonine kinome

Nature, 2023
Protein phosphorylation is one of the most widespread post-translational modifications in biology^ 1 , 2 . With advances in mass-spectrometry-based phosphoproteomics, 90,000 sites of serine and threonine phosphorylation have so far been identified, and ...
Jared L. Johnson, T. Yaron, Emily M Huntsman, A. Kerelsky, Junho Song, A. Regev, Ting Lin, Katarina M Liberatore, Daniel M. Cizin, Benjamin M. Cohen, N. Vasan, Yilun Ma, Konstantin Krismer, Jaylissa Torres Robles, Bert van de Kooij, Anne E. van Vlimmeren, Nicole Andrée-Busch, N. Käufer, Maxim V. Dorovkov, A. Ryazanov, Y. Takagi, Edward R. Kastenhuber, M. Goncalves, B. Hopkins, O. Elemento, D. Taatjes, A. Maucuer, A. Yamashita, A. Degterev, Mohamed Uduman, Jingyi Lu, Sean D. Landry, Bin Zhang, Ian Cossentino, R. Linding, J. Blenis, P. Hornbeck, B. Turk, M. Yaffe, L. Cantley   +39 more
semanticscholar   +1 more source

Learning to code: interplay of attitude, emotions, and fun

Humanities & Social Sciences Communications, 2023
There is a worldwide pursuit to increase children’s interest in STEM (Science, Technology, Engineering, Mathematics) especially in computer science through extra-curricular activities such as coding workshops, hackathons, and FabLab initiatives. However,
Gabriella Tisza, Panos Markopoulos, Tilde Bekker   +2 more
doaj   +1 more source

Approximation of a Microbiome Composition Shift by a Change in a Single Balance Between Two Groups of Taxa

mSystems, 2022
Linking microbiome composition obtained from metagenomic or 16S rRNA sequencing to various factors poses a real challenge. The compositional approach to such data is well described: a so-called isometric log-ratio (ILR) transform provides correct ...
Vera E. Odintsova, Natalia S. Klimenko, Alexander V. Tyakht   +2 more
doaj   +1 more source

The GTEx Consortium atlas of genetic regulatory effects across human tissues

Science, 2019
The Genotype-Tissue Expression (GTEx) project was established to characterize genetic effects on the transcriptome across human tissues and to link these regulatory mechanisms to trait and disease associations.
F. Aguet, A. Barbeira, Rodrigo Bonazzola, A. Brown, S. Castel, Brian Jo, S. Kasela, Sarah Kim-Hellmuth, Yanyu Liang, Meritxell Oliva, P. Parsana, Elise D. Flynn, L. Frésard, Eric R Gaamzon, Andrew R. Hamel, Yuan He, F. Hormozdiari, P. Mohammadi, Manuel Muñoz-Aguirre, YoSon Park, A. Saha, Ayellet V Segrć, B. Strober, Xiaoquan Wen, Valentin Wucher, Sayantani Das, D. Garrido-Martín, Nicole R. Gay, R. Handsaker, Paul J. Hoffman, Seva Kashin, Alan M. Kwong, Xiao Li, D. MacArthur, J. Rouhana, M. Stephens, E. Todres, A. Viñuela, Gao Wang, Yuxin Zou, Christopher D. Brown, N. Cox, E. Dermitzakis, B. Engelhardt, G. Getz, R. Guigó, S. Montgomery, Barbara E. Stranger, H. Im, A. Battle, K. Ardlie, T. Lappalainen   +51 more
semanticscholar   +1 more source

Efficient Parallelization of RooFit Computations for Accelerated Higgs Combination Fits [PDF]

EPJ Web of Conferences
In the context of High Energy Physics (HEP) analyses the advent of large-scale combination fits forms an increasing computational challenge for the underlying software frameworks on which these fits rely.
Wolffs Zef, Bos Patrick, Brenner Lydia, Verkerke Wouter, van Vulpen Ivo   +4 more
doaj   +1 more source

Retrospective analysis of biochemical markers in COVID-19 intensive care unit patients

The Egyptian Journal of Bronchology, 2022
Background The aim of the study was to evaluate the presence and effects of hematological and biological parameters in the diagnosis of the disease by performing blood tests on COVID-19 patients admitted to the intensive care unit (ICU).
Sema Ketenci, İlkay Saraçoğlu, Recep Duranay, Çağrı Serdar Elgörmüş, A. Şükrü Aynacıoğlu   +4 more
doaj   +1 more source