Results 41 to 50 of about 892,504 (360)

Fly Cell Atlas: a single-nucleus transcriptomic atlas of the adult fruit fly

Science, 2022
For more than 100 years, the fruit fly Drosophila melanogaster has been one of the most studied model organisms. Here, we present a single-cell atlas of the adult fly, Tabula Drosophilae, that includes 580,000 nuclei from 15 individually dissected sexed ...
Hongjie Li, Jasper Janssens, M. de Waegeneer, Sai Saroja Kolluru, K. Davie, V. Gardeux, Wouter Saelens, Fabrice P. A. David, Maria Brbić, Katina I. Spanier, J. Leskovec, C. McLaughlin, Qijing Xie, Robert C. Jones, Katja Brueckner, Jiwon Shim, S. G. Tattikota, F. Schnorrer, Katja Rust, T. Nystul, Z. Carvalho-Santos, C. Ribeiro, Soumitra Pal, Sharvani Mahadevaraju, T. Przytycka, Aaron M. Allen, S. Goodwin, Cameron W. Berry, M. Fuller, H. White-Cooper, E. Matunis, S. DiNardo, Anthony Galenza, L. O’Brien, J. Dow, Heinrich Jasper, B. Oliver, N. Perrimon, B. Deplancke, S. Quake, L. Luo, S. Aerts, D. Agarwal, Yasir Ahmed-Braimah, M. Arbeitman, Majd M. Ariss, Jordan Augsburger, Kumar Ayush, Catherine C. Baker, T. Banisch, Katja Birker, R. Bodmer, Benjamin Bolival, Susanna E. Brantley, J. Brill, Nora C. Brown, Norene A. Buehner, Xiao Cai, Rita Cardoso-Figueiredo, F. Casares, Amy K. Chang, T. R. Clandinin, Sheela Crasta, C. Desplan, A. Detweiler, D. Dhakan, E. Donà, Steffi Engert, Swann Floc’hlay, Nancy George, Amanda J. González-Segarra, A. Groves, Samantha C. Gumbin, Yanmeng Guo, Devon E. Harris, Y. Heifetz, Stephen L. Holtz, Felix Horns, Bruno Hudry, Ruei-Jiun Hung, Y. Jan, J. Jaszczak, G. Jefferis, Jim Karkanias, T. Karr, Nadja S. Katheder, James N. Kezos, Anna A. Kim, Seung K. Kim, L. Kockel, N. Konstantinides, T. Kornberg, H. Krause, Andrew Labott, M. Laturney, R. Lehmann, Sarah G. Leinwand, Jiefu Li, Joshua Shing Shun Li, Kai Li, Ke Li, Liying Li, Tun Li, M. Litovchenko, Hanji Liu, Yifang Liu, Tzu-Chiao Lu, J. Manning, A. Mase, Mikaela Matera-Vatnick, Neuza R. Matias, Caitlin E. McDonough-Goldstein, A. McGeever, A. McLachlan, Paola Moreno-Roman, N. Neff, Megan C. Neville, Sang M Ngo, Tanja Nielsen, C. O’BRIEN, David Osumi-Sutherland, M. N. Özel, I. Papatheodorou, M. Petkovic, C. Pilgrim, A. Pisco, C. Reisenman, E. Sanders, Gilberto dos Santos, Kristin Scott, Aparna Sherlekar, Philip K. Shiu, David Sims, R. Sit, Maija Slaidina, Harold E. Smith, Gabriella R. Sterne, Yun-Han Su, Daniel A. Sutton, Marco Tamayo, Michelle Tan, I. Tastekin, C. Treiber, David Vacek, Georg Vogler, S. Waddell, Wanpeng Wang, Rachel I. Wilson, M. Wolfner, Yiu-Cheung E. Wong, Anthony Xie, Jun Xu, Shinya Yamamoto, Jia-cheng Yan, Zepeng Yao, Kazuki Yoda, Ruijun Zhu, R. Zinzen   +157 more
semanticscholar   +1 more source

A comparison of BeadChip and WGS genotyping outputs using partial validation by sanger sequencing

BMC Genomics, 2020
Background Head-to-head comparison of BeadChip and WGS/WES genotyping techniques for their precision is far from straightforward. A tool for validation of high-throughput genotyping calls such as Sanger sequencing is neither scalable nor practical for ...
Kirill A. Danilov, Dimitri A. Nikogosov, Sergey V. Musienko, Ancha V. Baranova   +3 more
doaj   +1 more source

Automated anatomical labelling atlas 3

NeuroImage, 2020
Following a first version AAL of the automated anatomical labeling atlas (Tzourio-Mazoyer et al., 2002), a second version (AAL2) (Rolls et al., 2015) was developed that provided an alternative parcellation of the orbitofrontal cortex following the ...
E. Rolls, Chu-Chung Huang, Ching-Po Lin, Jianfeng Feng, M. Joliot   +4 more
semanticscholar   +1 more source

FROM PERSONALIZED TO PRECISION MEDICINE

Рациональная фармакотерапия в кардиологии, 2017
The need to maintain a high quality of life against a backdrop of its inevitably increasing duration is one of the main problems of modern health care.
K. V. Raskina, E. Y. Martynova, A. V. Perfilyev, D. A. Sychev, G. N. Shuev, I. R. Fatkhutdinov, S. V. Musienko, D. A. Nikogosov, I. O. Zhegulina, L. G. Bavykina, Y. E. Poteshkin   +10 more
doaj   +1 more source

CASTp 3.0: computed atlas of surface topography of proteins

Nucleic Acids Res., 2018
Geometric and topological properties of protein structures, including surface pockets, interior cavities and cross channels, are of fundamental importance for proteins to carry out their functions. Computed Atlas of Surface Topography of proteins (CASTp)
Wei Tian, Chang Chen, X. Lei, Jieling Zhao, Jie Liang   +4 more
semanticscholar   +1 more source

The Tabula Sapiens: A multiple-organ, single-cell transcriptomic atlas of humans

bioRxiv, 2021
Molecular characterization of cell types using single cell transcriptome sequencing is revolutionizing cell biology and enabling new insights into the physiology of human organs.
S. Quake
semanticscholar   +1 more source

Vinorelbine- Autophagy Agent Combinations Induce Synergistic Cytotoxicity in SH-SY5Y Neuroblastoma Cells

Recent Trends in Pharmacology
Objective: To investigate whether pharmacological agents associated with autophagy induction or inhibition modulate vinorelbine-induced cytotoxic responses in SH-SY5Y neuroblastoma cells.
Berna Yıldırım, Melike Seçilmiş, Burcu Biltekin, Mete Hakan Karalök, Turgay Barut, Ayhan Bilir   +5 more
doaj   +1 more source

Short bowel syndrome after near total enterectomy in an elderly patient: case report and review of the literature [PDF]

Exploration of Digestive Diseases
Acute mesenteric ischemia (AMI) is a rare but highly lethal vascular emergency resulting from the abrupt interruption of intestinal blood flow. In advanced stages, extensive bowel necrosis may require near total enterectomy, leading to short bowel ...
Emine Yildirim, Ahmet Sezer Sezgin, Kudret Kirsan, Cagla Feyzioglu, Asude Nur Say, Abdulhalim Senyigit, Omer Ozyigit, Hafize Uzun   +7 more
doaj   +1 more source

A single-cell atlas of the peripheral immune response in patients with severe COVID-19

Nature Medicine, 2020
There is an urgent need to better understand the pathophysiology of Coronavirus disease 2019 (COVID-19), the global pandemic caused by SARS-CoV-2, which has infected more than three million people worldwide1.
A. Wilk, A. Rustagi, Nancy Q. Zhao, J. Roque, Giovanny J. Martínez-Colón, J. McKechnie, Geoffrey T. Ivison, T. Ranganath, Rosemary Vergara, Taylor Hollis, L. Simpson, P. Grant, A. Subramanian, A. Rogers, C. Blish   +14 more
semanticscholar   +1 more source

Low discontinuation rate of tirzepatide treatment in Japanese patients with diabetes mellitus; importance of traditional Japanese diet

Journal of Health, Population and Nutrition
Tirzepatide, a novel dual GIP and GLP-1 receptor agonist, has demonstrated robust efficacy in clinical trials; however, discontinuation rates due to gastrointestinal adverse events have been reported at 6–10% in Western populations. In contrast, our real-
Takahiro Hiraide, Yoshihiko Suzuki, Satoko Yamamoto, Soroku Yagihashi, Motoaki Sano   +4 more
doaj   +1 more source