Results 61 to 70 of about 892,504 (360)

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

malariaAtlas: an R interface to global malariometric data hosted by the Malaria Atlas Project

Malaria Journal, 2018
Background The Malaria Atlas Project (MAP) has worked to assemble and maintain a global open-access database of spatial malariometric data for over a decade.
Daniel A. Pfeffer, Timothy C. D. Lucas, Daniel May, Joseph Harris, Jennifer Rozier, Katherine A. Twohig, Ursula Dalrymple, Carlos A. Guerra, Catherine L. Moyes, Mike Thorn, Michele Nguyen, Samir Bhatt, Ewan Cameron, Daniel J. Weiss, Rosalind E. Howes, Katherine E. Battle, Harry S. Gibson, Peter W. Gething   +17 more
doaj   +1 more source

Editorial–This Is Not an Atlas

, 2018
This chapter introduces the basic idea of »This Is Not an Atlas« and its history. It explains why the publication starts with a love-hate relation to maps and atlases. It also shows how critical cartography can be a starting point for both, criticizing the power of maps as well as actively engaging in mapping and making critical maps.
Severin Halder, Boris Michel
openaire   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

An anatomically comprehensive atlas of the adult human brain transcriptome

Nature, 2012
Neuroanatomically precise, genome-wide maps of transcript distributions are critical resources to complement genomic sequence data and to correlate functional and genetic brain architecture.
M. Hawrylycz, E. Lein, A. Guillozet‐Bongaarts, E. Shen, Lydia Ng, Jeremy A. Miller, L. N. V. D. Lagemaat, Kimberly A. Smith, Amanda J. Ebbert, Z. Riley, Chris Abajian, C. Beckmann, Amy Bernard, Darren Bertagnolli, A. Boe, P. Cartagena, M. Chakravarty, Mike Chapin, Jimmy Chong, R. Dalley, B. Daly, Chinh Dang, S. Datta, N. Dee, Tim Dolbeare, V. Faber, David Feng, David R. Fowler, Jeff Goldy, B. Gregor, Zeb Haradon, D. Haynor, J. Hohmann, S. Horvath, Robert E. Howard, A. Jeromin, Jayson M. Jochim, M. Kinnunen, C. Lau, E. Lazarz, Changkyu Lee, Tracy A. Lemon, Lingling Li, Yang Li, J. Morris, C. Overly, Patrick D. Parker, Sheana E. Parry, M. Reding, J. Royall, J. Schulkin, P. A. Sequeira, C. Slaughterbeck, Simon C. Smith, Andrew Sodt, S. Sunkin, B. Swanson, M. Vawter, Derric Williams, Paul E. Wohnoutka, H. Zielke, D. Geschwind, P. Hof, Stephen M. Smith, Christof Koch, S. Grant, Allan R. Jones   +66 more
semanticscholar   +1 more source

ATLAS Feature: Looking inside trillion degree matter

, 2022
Images included in the ATLAS Feature article, "Looking inside trillion degree matter with ...
ATLAS Collaboration
core  

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Análisis de la apariencia de los recubrimientos y ensayos de durabilidad de defectos inducidos en superficies usando un sistema de análisis de proceso de captación digital de imágenes

Revista de Metalurgia, 2003
No hay técnicas establecidas o aceptadas para una caracterización precisa de los cambios de apariencia dados por los rayones profundos y daños superficiales en los recubrimientos.
F. Lee, B. Pourdeyhimi, C. Hazzard, J. Summerville   +3 more
doaj   +1 more source

Atlas Drugged [PDF]

Cell, 2019
Vasaikar et al. report a comprehensive proteogenomic analysis of 110 colon cancer samples to identify a variety of potential signaling and metabolic targets, neoantigens, and biomarkers. This resource helps expand our understanding of the fundamental pathophysiology of this tumor type, and future mechanistic studies should help guide novel therapeutic ...
Jung-Kuei, Chen, Michael B, Yaffe
openaire   +2 more sources