Results 71 to 80 of about 657,034 (319)
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Quality and reliability of YouTube videos on breast engorgement
International Breastfeeding JournalBackground Breast engorgement is a common and painful condition that can lead to the early cessation of breastfeeding. Many mothers turn to online platforms like YouTube for information and support, but the quality of this content is often unverified ...
Şehma Şen +2 more
doaj +1 more source
Mapping malaria seasonality in Madagascar using health facility data
BMC Medicine, 2020 Background Many malaria-endemic areas experience seasonal fluctuations in case incidence as Anopheles mosquito and Plasmodium parasite life cycles respond to changing environmental conditions.
Michele Nguyen +19 more
doaj +1 more source
ATLAS Event Display: Triple W-boson Production [PDF]
, 2021 Candidate event displays of three W bosons produced in the ATLAS ...
ATLAS Collaboration
core
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Identifying mental health status using deep neural network trained by visual metrics
Translational Psychiatry, 2020 Mental health is an integral part of the quality of life of cancer patients. It has been found that mental health issues, such as depression and anxiety, are more common in cancer patients. They may result in catastrophic consequences, including suicide.
Somayeh B. Shafiei +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
ATLAS Outstanding Achievement Awards 2015 [PDF]
, 2015 ATLAS Outstanding Achievement Awards ceremony, 18 June ...
ATLAS Collaboration
core
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Discover Artificial IntelligenceThis study presents a deep learning framework that integrates gene expression and proteomic-proxy features to predict breast cancer biomarkers ER, PR, and HER2.
Naim Ajlouni, Abdelrahman Almassri
doaj +1 more source