Results 221 to 230 of about 596,401 (334)

Novel ATR/PARP1 Dual Inhibitors Demonstrate Synergistic Antitumor Efficacy in Triple‐Negative Breast Cancer Models

open access: yesAdvanced Science, EarlyView.
Novel ATR/PARP1 dual inhibitors are developed for the first time. Advanced lead B8 effectively reduces cell viability in vitro and suppresses tumor growth in vivo, with better potency than ATRi and PARPi alone or in combination. Mechanistically, B8 induces apoptosis, arrests the cell cycle, and inhibits cancer cells colony formation, migration, and ...
Yuan Gao   +13 more
wiley   +1 more source

Abiotic Factors and Plant Communities Shape the Distribution of Soil Pathogenic Oomycetes in Chinese Grasslands

open access: yesAdvanced Science, EarlyView.
The continental‐scale study reveals that soil phosphorus strongly predicts the richness of soil pathogenic oomycetes in Chinese grasslands, while precipitation and plant species richness drive their absolute abundance; modeling predicts ≈42% of grassland areas may face elevated oomycete disease risk under future climate scenarios, especially in typical
Junsheng Ke   +10 more
wiley   +1 more source

Genetic Regulation of Alternative Polyadenylation Provides Novel Insights into Molecular Mechanisms Underlying Non‐small Cell Lung Cancer

open access: yesAdvanced Science, EarlyView.
Compared with the non‐risk G allele of rs9606, the risk T allele of rs9606 decreases the binding affinity of NUDT21 for LYRM4, triggering 3'UTR shortening that stabilizes LYRM4 mRNA and elevates its expression. Increased LYRM4 expression promoted malignant phenotypes of non‐small cell lung cancer (NSCLC) cells through modulating ferroptosis, supporting
Meng Jin   +11 more
wiley   +1 more source

Amino Acid‐Sensing Neurons in the Anterior Piriform Cortex Control Brown Adipose Tissue Thermogenesis

open access: yesAdvanced Science, EarlyView.
This study identifies a class of amino acid‐sensing neurons, APCCRH neurons, which regulate BAT thermogenesis. Leucine deficiency alters intrinsic excitability through GCN2 signaling pathway, activating APCCRH neurons, which in turn regulate BAT thermogenesis via projections to the lateral hypothalamus.
Peixiang Luo   +15 more
wiley   +1 more source

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