Results 81 to 90 of about 729,804 (377)

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

A Rare Presentation of Os Odontoideum with Multiple Vertebral Fusion in Type III Klippel-Feil Syndrome (KFS) – A Case Report [PDF]

Journal of Clinical and Diagnostic Research, 2014
An abnormal atlas and axis with presence of os odontoideum and fusion of multiple vertebrae were noted in an intact skeleton, in the osteology museum of the Department of Anatomy of North Bengal Medical College, West Bengal, India.These multiple ...
Shabana Begum, Tanushree Roy, Tanwi Ghosal (Sen), Indrajit Gupta   +3 more
doaj   +1 more source

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

FEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan, Bethany C. Guerra, Selina Uranga, Jessica M. Cardin, Steven E. Riechman, Mariana Janini Gomes, James D. Fluckey   +6 more
wiley   +1 more source

PSACNN: Pulse Sequence Adaptive Fast Whole Brain Segmentation

, 2019
With the advent of convolutional neural networks~(CNN), supervised learning methods are increasingly being used for whole brain segmentation. However, a large, manually annotated training dataset of labeled brain images required to train such supervised ...
Fischl, Bruce, Greve, Douglas N., Hoopes, Andrew, Jog, Amod, Van Leemput, Koen   +4 more
core   +1 more source

The Human Brainnetome Atlas: A New Brain Atlas Based on Connectional Architecture

Cerebral Cortex, 2016
The human brain atlases that allow correlating brain anatomy with psychological and cognitive functions are in transition from ex vivo histology-based printed atlases to digital brain maps providing multimodal in vivo information.

semanticscholar   +1 more source

Lesion Location and Functional Connections Reveal Cognitive Impairment Networks in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Cognitive impairment, fatigue, and depression are common in multiple sclerosis (MS), potentially due to disruption of regional functional connectivity caused by white matter (WM) lesions. We explored whether WM lesions functionally connected to specific brain regions contribute to these MS‐related manifestations.
Alessandro Franceschini, Paolo Preziosa, Paola Valsasina, Damiano Mistri, Monica Margoni, Federica Esposito, Massimo Filippi, Maria A. Rocca   +7 more
wiley   +1 more source

Interactive three-dimensional atlas of the mineralized skeleton of the sand tiger shark Carcharias taurus

Royal Society Open Science
Non-invasive computed tomography (CT) of an adult sand tiger shark Carcharias taurus Rafinesque, 1810 is used to provide an interactive three-dimensional ‘general’ shark (Selachimorpha) anatomy atlas.
Emil Alexander Byriel Winkel, Rune Kristiansen, Peter Rask Møller, Henrik Lauridsen   +3 more
doaj   +1 more source

Complete occipitalization of atlas vertebra with other congenital malformations - a rare variation

National Journal of Clinical Anatomy, 2015
Occipitalization of the atlas vertebra or atlantooccipital fusion represents the most cephaled blocked vertebra found in the vertebral column. It is defined as the congenital bony fusion of the atlas vertebra to the base of the occipital bone of the ...
PoonamVerma, Seema, Anupama Mahajan
doaj   +1 more source

CSF Levels of NPTX2 Are Associated With Less Brain Atrophy Over Time in Cognitively Unimpaired Individuals

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Introduction Neuronal pentraxin 2 (NPTX2) is a synaptic protein involved in synaptic plasticity and regulation of neuronal excitability. Lower baseline cerebrospinal fluid (CSF) NPTX2 levels have been shown to be associated with an earlier onset of mild cognitive impairment (MCI), a pre‐dementia syndrome, even after CSF Alzheimer's Disease (AD)
Juan P. Vazquez, Corinne Pettigrew, Yuxin Zhu, Claire Anderson, Guray Erus, Christos Davatzikos, Michael Miller, Abhay Moghekar, Sungtaek Oh, Chan‐Hyun Na, Marilyn Albert, Paul Worley, Anja Soldan   +12 more
wiley   +1 more source

Bayesian Estimation of Probabilistic Atlas for Anatomically-Informed Functional MRI Group Analyses [PDF]

, 2013
International audienceTraditional analyses of Functional Magnetic Resonance Imaging (fMRI) use little anatomical information. The registration of the images to a template is based on the individual anatomy and ignores functional information; subsequently
Allassonnière, Stéphanie, Thirion, Bertrand, Xu, Hao   +2 more
core   +1 more source