Results 111 to 120 of about 275,008 (315)

Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer

FEBS Open Bio, EarlyView.
Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold, Janik Riese, Lancelot Seillier, Mark Kühnel, Julia Pannhausen, Charlotte O. J. Fröhlich, Christian Martin, Peter Boor, Matthias Saar, Danny D. Jonigk, Nadine T. Gaisa, Michael Rose   +11 more
wiley   +1 more source

Análises das diretrizes para o apoio institucional das gestões da Atenção Básica das capitais brasileiras

Saúde em Debate
Objetivou-se investigar os limites e as potencialidades das diretrizes gerais das gestões da Atenção Básica das capitais brasileiras para o apoio institucional. O estudo é descritivo, exploratório, qualitativo, realizado de fevereiro a outubro de 2014, a
Lygia Maria de Figueiredo Melo, Claudia Santos Martiniano, Jacileide Guimarães, Marize Barros de Souza, Paulo de Medeiros Rocha   +4 more
doaj   +1 more source

Choosing ICT Tools: Proposition of a Model to Deliver Value for Clients

Journal of Technology Management & Innovation, 2013
Several tools of Information and Communication Technology (ICT) are being used nowadays to support customer relationship processes. Literature review shows that, in the selection and deployment of these tools, internal goals of productivity and ...
Paulo Grise, Melby Karina Zuniga Huertas
doaj   +1 more source

The cooperative regulation of miR‐221 by APE1 and AUF1 impacts p27Kip1 defining a miR signature relevant for cervical cancer

FEBS Open Bio, EarlyView.
A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti, Nicolò Gualandi, Gianluca Tell, Giulia Antoniali   +3 more
wiley   +1 more source

Caracterización de la cultura organizacional de una institución de educación superior

Psicogente, 2012
In order to characterize the organizational culture of an institution of higher education located in the city of Bogotá, this descriptive research implemented a mixed methodology using the techniques of qualitative data collection in focus groups and a ...
Jaime Ferro Vásquez, David Bernal Giraldo, Liliana Andrea Torres, Pamela Noriega Serrano   +3 more
doaj  

Recursos para la inclusión educativa en el contexto de educación primaria

Infancias Imágenes, 2014
El propósito la presente investigación es identificar los requisitos y recursos necesarios para la atención a la diversidad e inclusión educativa en el contexto de educación primaria. Se realizó un estudio mixto (cuantitativo y cualitativo).
Blanca Aurelia Valenzuela, Reyna de los Ángeles Campa Álvarez, Manuela Guillén Lúgigo   +2 more
doaj   +1 more source

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

FEBS Open Bio, EarlyView.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui, Taobo Hu, Thomson Christian Husein, Wai Hei Shek, Bingrong Chen, Depeng Wang, Shu Wang, Weichuan Yu, Xiaodan Fan, Mengping Long, Toyotaka Ishibashi   +10 more
wiley   +1 more source

A multi-method proposal to study the Public Space in the Scale of Neighborhood from a Transactional Approach Una propuesta Multimétodo para un Abordaje Transaccional del Espacio Público en la Escala de Barrio

Athenea Digital, 2012
The transactional perspective is very attractive to analyze and act on public space on the scale of the neighborhood, however, language and methodological differences between the various disciplines involved make it quite complex.
Hector Rodrigo Berroeta Torres, Tomeu Vidal Moranta   +1 more
doaj  

Sentidos e significados da participação democrática através da Internet: uma análise da experiência do Orçamento Participativo Digital

Revista de Administração Pública, 2014
Este trabalho analisa três edições (2006, 2008 e 2011) do Orçamento Participativo Digital (OPD) de Belo Horizonte (MG). Objetiva deslindar os sentidos e significados da participação democrática mediada pela internet nessa experiência.
Júlio Cesar Andrade de Abreu, José Antonio Gomes de Pinho   +1 more
doaj   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source