Results 141 to 150 of about 808,349 (313)

Inhibition of IGFBP4 in Granulosa Cells Improves Reproductive Performance and Maintains Fertility With Age via YAP Signaling

Advanced Science, EarlyView.
IGFBP4 is upregulated in granulosa cells of aged ovaries across monkeys, mice, and humans. It inhibits YAP signaling, thereby suppressing cell proliferation and contributing to follicular dysfunction. Deletion of Igfbp4 in granulosa cells enhances ovulatory output, improves hormone profiles, and reproductive performance in aged female mice, suggesting ...
Qianhui Hu, Ajun Geng, Ziyuan Li, Fanghao Guo, Jingqiang Wang, Xinyi Chen, Meiling Zhang, Yi Arial Zeng, Wen Li   +8 more
wiley   +1 more source

The combined use of scRNA-seq and network propagation highlights key features of pan-cancer Tumor-Infiltrating T cells.

PLoS ONE
Improving the selectivity and effectiveness of drugs represents a crucial issue for future therapeutic developments in immuno-oncology. Traditional bulk transcriptomics faces limitations in this context for the early phase of target discovery as ...
Adèle Mangelinck, Elodie Molitor, Ibtissam Marchiq, Lamine Alaoui, Matthieu Bouaziz, Renan Andrade-Pereira, Hélène Darville, Etienne Becht, Céline Lefebvre   +8 more
doaj   +1 more source

ATLAS data-taking milestone: 1EB of data

ATLAS enters the exascale! The ATLAS experiment has 1 EB (1 billion billion bytes) of real and simulated data worldwide, managed using ...
ATLAS Collaboration
core  

Coixenolide Enhances Antitumor Immunity of Cytotoxic CD8+ T Cells by Inhibiting S100A8/A9‐CD36 Axis in Obesity‐Associated Pancreatic Adenocarcinoma

Advanced Science, EarlyView.
Pancreatic adenocarcinoma (PAAD) remains highly lethal with limited treatment options. This study demonstrates that coixenolide, a bioactive compound from Coix lacryma‐jobi L. and a key component of the clinically approved Kanglaite injection, exhibits enhanced antitumor efficacy in high‐fat diet (HFD)‐induced obese mice bearing PAAD tumors compared to
Kaidi Chen, Rong Chen, Wei Li, Bin Song, Ruiying Zhang, Lewei Dai, Yuwei Qi, Ruqian Chen, Yifan Xu, Hangbin Li, Jingyi Huang, Fangping Wu, Jianan Peng, Xinyu Wang, Yang Xiong, Chaofeng Mu, Guilin Cheng, Zhaoshen Li, Shanming Ruan, Lei Huang, Mancang Gu   +20 more
wiley   +1 more source

Multilab replicatieonderzoek, kwalitatieve simulatie- en observatieanalyse met Atlas-ti

, 2018
Presentatie van multilab replicatieonderzoek Ulrich 1991, en simulatie spreek-/onderzoekskamer Nij Smellinghe en ander studentenonderzoek met Atlas-ti in het lectoraat Facility ...
openaire  

ATLAS "Splash event" September 10, 2008

, 2014
September 10, 2008 - A 'splash event' as ATLAS detects particles from nearby collisions from the first beams through the ...
ATLAS, Experiment
core  

INVESTIMENTOS EM TI VERSUS PLANEJAMENTO: UMA AVALIAÇÃO NAS INSTITUIÇÕES DE ENSINO DA AMAZÔNIA LEGAL [PDF]

, 2014
O objetivo deste artigo é identificar as instituições de ensino públicas federais da Amazônia Legal brasileira que realizaram planejamento específico para a área de tecnologia da informação (TI).
Tourinho, Maria Berenice Alho da Costa, Bravim, Jhordano Malacarne, Falcão, Leonardo, Leandro, Marcos Roberto de Lima   +3 more
core  

Transcription Factor Promiscuity Drives Regulatory Rewiring and Evolvability in Gene Networks in Bacteria

Advanced Science, EarlyView.
When a master transcription factor (TF) is lost, bacteria can rapidly rewire gene regulatory networks by co‐opting related regulators. Using experimental evolution in Pseudomonas fluorescens, we show that TF promiscuity (low‐level, non‐cognate binding) provides the raw material for rewiring. Successful co‐option follows a predictable hierarchy governed
Tiffany B. Taylor, Alan M. Rice
wiley   +1 more source

Single‐Cell Dissection of Therapy‐Induced Remodeling Uncovers a Fibroblast‐Driven Immunosuppressive Niche and Targetable Vulnerabilities in Lethal Prostate Cancer

Advanced Science, EarlyView.
Single‐cell longitudinal profiling reveals that androgen‐deprivation therapy induces a DPT+ fibroblast‐complement axis that suppresses macrophage inflammation and drives CD8+ T cell exhaustion in prostate cancer. Concurrently, resistant epithelial subpopulations persist and engage TSPAN1‐ and NRXN1‐mediated programs promoting CRPC and neuroendocrine ...
Yang Chen, Dandan Dong, Jinling Liao, Naikai Liao, Mengqi Liu, Qin Zhang, Siting Chen, Qi Liu, Ying Lu, Tianyu Li, Chunlin Zou, Qiong Song, Qiuyan Wang, Jian Liang, Qiji Xie, Chengyang Li, Mengyun Wang, Jiwen Cheng, Zengnan Mo, Gong‐Hong Wei   +19 more
wiley   +1 more source

RENEWING SOCIOLOGICAL ANALYSIS TOOLS IN THE AGE OF ARTIFICIAL INTELLIGENCE: A CRITICAL ASSESSMENT OF THE EXPERIENCES WITH MONKEYLEARN, NVIVO AI, AND ATLAS. TI

Metafizika Journal
This study aims to evaluate the effectiveness of artificial intelligence applications in renewing sociological analysis tools among postgraduate students, particularly those who are delayed in completing their scientific research. The study focuses on three primary applications: MonkeyLearn, NVivo AI, and Atlas.
openaire   +1 more source