Results 211 to 220 of about 808,349 (313)

Deconstruction of Human Age‐Related Cataract Capsules Defines Aging

Advanced Science, EarlyView.
We generate a comprehensive atlas of age‐related cataracts (ARC) at a single‐cell resolution, encompassing three disease states—mild cataract group (Mild), severe cortical cataract group (Severe_C), and severe nuclear cataract group (Severe_N). We find that ARC involves seven distinct lens capsule cell types, with notable differences in cellular ...
Qiaomei Tang, Ziyang Tong, Chunmei Fan, Silong Chen, Jiarui Guo, Jianghua Hu, Ke Yao, Zi Yin, Xiao Chen, Yibo Yu   +9 more
wiley   +1 more source

A method for analysing tissue motion and deformation during mammalian organogenesis. [PDF]

PLoS Comput Biol
Raiola M, Esteban I, Ivanovitch K, Sendra M, Torres M.   +4 more
europepmc   +1 more source

CALB2 is a Mechanoresistance Gene in Metastatic Prostate Cancer

Advanced Science, EarlyView.
Prostate cancer cell lines of differing origins were cultured over many passages while being subjected to semi‐lethal levels of fluid shear stress, representing the harsh mechanical environment these cells are subjected to in the circulation during the process of distant metastasis.
Abigail R. Fabiano, Allen C. Luo, Paul Taufalele, Jenna A. Dombroski, Ehsan Aalaei, Schyler J. Rowland, Melissa S. Cantú, Alexandria T. Carter, Samantha V. Knoblauch, Cynthia A. Reinhart‐King, Michael R. King   +10 more
wiley   +1 more source

InnerEye-HS: a disease-agnostic clinical tool for hippocampal segmentation. [PDF]

Brain Commun
Schroder A, Moggridge J, Salhab HA, Micallef C, Wu J, Bristow M, Pérez-García F, Alvarez-Valle J, Vos SB, Yousry TA, Thornton JS, Barkhof F, Duncan JS, Alexander DC, Grech-Sollars M.   +14 more
europepmc   +1 more source

Multi‐regional Organoid Biobank Reveals FAK‐ACSL1‐Driven Doxorubicin‐Resistance and Predictive Biomarkers in Breast Cancer

Advanced Science, EarlyView.
This study established a high‐quality organoid biobank derived from 68 tumor sites across 50 Chinese patients, elucidated the drug sensitivity‐based molecular subtyping in breast cancer, and revealed a novel mechanism of drug resistance mediated by the FAK‐ACSL1 pathway.
Hao Xu, Zhijun Qin, Jiapeng Yang, Baoyuan Zhang, Manqing Cao, Peng Wang, Zaiqi Wang, Jinghui Cheng, Lei Wang, Hong Liu, Hui Yang   +10 more
wiley   +1 more source

Biomechanical Evaluation of Different Posterior Mandibular Implant Configurations Under Bruxism: An FEA Study. [PDF]

J Funct Biomater
Ates M, Akin C.
europepmc   +1 more source

Single‐cell Transcriptome Profiling Reveals Gene Regulatory Networks and Key Genes in the Root Epidermis and Cortical Cells Associated with Early Nodulation in Glycine Max

Advanced Science, EarlyView.
Single‐cell transcriptomics of soybean roots soon after rhizobial inoculation reveals epidermal and cortical cell‐specific programs and gene‐regulatory networks acting in symbiosis establishment. We identify an ethylene‐driven regulatory circuit involving WRKY6.3/6.4 transcription factors targeting select Nod19 genes that promotes infection‐thread ...
Yongbin Zhuang, Yu Geng, Xinyu Guo, Chen Wang, Yongjing Sun, Luqi Liu, Li Liu, QianQian Gao, XinFang Zhu, Hongxiang Cao, Gengshuo Zhang, Yunxia Liu, Guobin Zhang, Baoyin Chen, Jinfei Zhang, Xin Hou, Xiaoming Li, Dajian Zhang   +17 more
wiley   +1 more source

GRAIL-heart: A graph attention network for inferring ligand-receptor interactions in spatial transcriptomics. [PDF]

MethodsX
Kgabeng T, Wang L, Ngwangwa H, Nemavhola F, Pandelani T.   +4 more
europepmc   +1 more source

A Pan‐Methylome Framework for Population‐Scale Bacterial Epigenomics

Advanced Science, EarlyView.
A scalable quantitative framework unlocks population‐level comparative epigenomics in bacteria. By transforming site‐level data into standardized traits, this approach reconstructs methylation‐informed phylogenies and defines the core epigenome.
Bin Ma, Huimin Gong, Ran Zhuo, Zaixiao Rao, Yanxi Wan, Mingyang Wang, Zahra Zeinalzadeh, Yuan Gao, Aohan Guan, Xinrun Li, Wanting Chen, Xiliang Wang, Yun Wan, Sihua Zhang, Yuncai Xiao, Qi Huang, Paul R. Langford, Xiangru Wang, Rui Zhou, Rui Luo, Hongbo Zhou, Chengliang Zhu, Hui Jin   +22 more
wiley   +1 more source

Single-cell RNA sequencing of terminal ileal biopsies identifies signatures of Crohn's disease pathogenesis. [PDF]

Nat Genet
Krzak M, Alegbe T, Taylor DL, Jones GR, Ghouraba M, Strickland M, Harris BT, Satti R, Arestang K, Ramirez-Navarro L, Nishad N, Cheam KAX, Tutert M, Ozols M, Noell G, Leonard S, Przybilla MJ, Suastegui CR, Khabirova E, Deng T, Najgebauer H, Petrova V, Jones CP, Wana N, Hu MX, Skelton J, Ostermayer J, Gu Y, Garri W, Brezina B, Caballes CQ, Corridoni D, Parkes M, Iyer V, Martin CC, McIntyre RE, Raine T, Anderson CA.   +37 more
europepmc   +1 more source