Results 241 to 250 of about 275,008 (315)

Personalized high-intensity temporal interference stimulation decouples cerebellar networks to enhance implicit learning. [PDF]

J Neuroeng Rehabil
Tang D, Qin L, Hu L, Jian Y, Gao S, Huang Z, Cai L, Shao X, Chang C, Zhao G, Zhu Z.   +10 more
europepmc   +1 more source

SLC2A3‐Mediated Lactate Metabolism Promotes Lung Cancer Bone Metastasis by Modulating P53 Lactylation and Immune Evasion

Advanced Science, EarlyView.
SLC2A3 derived lactate promotes metastasis through p53 lactylation at K120 and osteoclast differentiation. Pharmacological inhibition of SLC2A3 upregulates PD‐1 expression on CD8+ T cells via lactate induced p53 lactylation, which modulates immune evasion. ABSTRACT Bone metastasis is a devastating consequence of lung cancer.
Yi Ding, Yuying Tian, Wenjie Ren, Xianglin Hu, Mengjuan Li, Bei Liu, Chen chen, Yunhan Lu, Lei Li, Wangjun Yan, Kun Li   +10 more
wiley   +1 more source

Radiographic prevalence and associated factors of hallux rigidus in a large-scale population-based cohort. [PDF]

Osteoarthr Cartil Open
Yagi Y, Matsumoto T, Uchio A, Takeda R, Iidaka T, Horii C, Oka H, Muraki S, Hashizume H, Yamada H, Yoshida M, Nakamura K, Tanaka S, Yoshimura N.   +13 more
europepmc   +1 more source

Promotion of DFU Wound Healing via BRG1–COL16A1 Axis in Fibroblasts

Advanced Science, EarlyView.
In normal wound healing, transcription factor BRG1 is upregulated and binds the COL16A1 promoter to enhance its expression, promoting fibroblast proliferation, migration, contraction, extracellular matrix deposition, and granulation tissue formation, thus accelerating wound closure.
Penghui Wang, Jiaming Sun, Ying Wang, Bichen Ren, Yuxin Liu, Yunhan Liu, Liang Chen, Lu Yu, Tao Dai, Li Yu, Zhihui Dong   +10 more
wiley   +1 more source

Tissue-specific and circulatory immune signatures of mucosal inflammation in Crohn’s disease

Ramirez-Navarro L, Jones G, Alegbe T, Harris BT, Strickland M, Ghouraba M, Ostermayer J, Wana N, Hu MX, Skelton J, Garri W, Brezina B, Caballes CQ, Leonard S, Iyer V, McIntyre RE, Parkes M, Martin CC, Anderson CA, Raine T.   +19 more
europepmc   +1 more source

MRI-based human brain atlases of R1, R2, proton density, and myelin volume fraction using synthetic quantitative imaging at 1.5 T. [PDF]

J Neurol
Sbaihat H, Roenneke K, Müller D, Ladopoulos T, Schneider R, Krieger B, Bellenberg B, Lukas C.   +7 more
europepmc   +1 more source

Single‐Cell Atlas of Subchondral Bone Marrow Lesions Reveals Proteostasis Dysfunction as a Druggable Mechanism for Early Osteoarthritis

Advanced Science, EarlyView.
This study reveals that abnormal mechanical stress downregulates the expression of HSP70 and impairs proteasome function in osteoarthritic bone cells, leading to misfolded collagen I accumulation and ER stress. When intracellular proteostasis capacity is exceeded, USP19 mediates the secretion of misfolded proteins into the extracellular space ...
Hailun Xu, Ting He, Yu Qian, Jia Li, Bowei Ni, Xiaojie Xu, Huanbo Wang, Peng Wang, Guoqing Cao, Siqi Ying, Guangyu Ding, Rong Wang, Zenghui Gu, Wei Li, Zhentao Man, Houfeng Zheng, Zhaohua Zhu, Zhen Li, Qingjun Meng, Chao Zheng, Liu Yang   +20 more
wiley   +1 more source

Systematic identification and targeting of master regulator checkpoints (MRC) governing tumor microenvironment-mediated immune evasion. [PDF]

J Immunother Cancer
Laise P, Bosker G, Babor M, Sun X, Andrews S, Tomassoni L, Califano A, Alvarez M.   +7 more
europepmc   +1 more source