Results 71 to 80 of about 1,040,330 (310)

Quantification et bilan de matiere de la reaction clinopyroxene-spinelle lors de la formation du plagioclase dans les lherzolites a spinelle

Estudios Geologicos, 1998
La formación de plagioclasa sódica (Pl) y de vidrio en las peridotitas de Saghro (Anti-Atlas marroquí) y de La Palma (Islas Canarias) se puede explicar como resultado de un proceso de metasomatismo y de fusión parcial de climpyroxeno (Cpx) y espinela ...
A. Ibhi, H. Nachit, M. Berrahma, H. Abia, J. Hernández   +4 more
doaj   +1 more source

Análisis de la implementación de una Política Pública Educativa utilizando la herramienta Atlas Ti

miradas (Pereira), 2022
Una política pública se genera de la necesidad de modificar una situación problema identificada en una sociedad, por medio de acciones tomadas desde un ente gubernamental (Deubel, 2002) en Colombia en el año 2015 se planteó la Política de Día de la Excelencia como respuesta a la necesidad de mejorar los resultados académicos y alcanzar el objetivo de ...
openaire   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Performance of temperature and radiation index models for point-scale snow water equivalent (SWE) simulations in the Moroccan High Atlas Mountains

Hydrological Sciences Journal, 2018
Four models of increasing complexity were tested and compared to simulate snow water equivalent at the local scale in the Moroccan High Atlas range. A classical temperature index model (TI) and three enhanced temperature index models that respectively ...
H. Bouamri, A. Boudhar, S. Gascoin, C. Kinnard   +3 more
semanticscholar   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Sentidos e significados da trajetória laboral de uma pessoa com deficiência no mundo do trabalho

Revista Trabalho, Política e Sociedade
A pesquisa visa compreender o processo de inclusão no mercado de trabalho a partir da narrativa dos sentidos e significados da trajetória laboral de uma pessoa com deficiência. Na perspectiva da Psicologia Social dodo Trabalho assumem-se os conceitos de
Carolina Moreira de Pinho Tavares, Fabiana Pinto de Almeida Bizarria, Flávia Lorenne Sampaio Barbosa   +2 more
doaj   +1 more source

UNA APROXIMACIÓN A LOS PATRONES DE COMUNICACIÓN ENTRE EL PROFESOR MENTOR Y EL PROFESOR-ESTUDIANTE EN EL CONTEXTO DE LA PRÁCTICA PEDAGÓGICA

Educación XX1, 2012
Puesto que la Formación Inicial Docente (FID) ha sido, en este último tiempo, parte de la agenda nacional del Ministerio de Educación de Chile, este estudio tiene como objetivo comprender los patrones de comunicación establecidos entre un grupo ...
Claudio Díaz Larenas, Cecilia Bastías Díaz   +1 more
doaj   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source