Results 91 to 100 of about 634,659 (335)
Resolving parameter degeneracies in long-baseline experiments by atmospheric neutrino data
, 2005 In this work we show that the physics reach of a long-baseline (LBL) neutrino oscillation experiment based on a superbeam and a megaton water Cherenkov detector can be significantly increased if the LBL data are combined with data from atmospheric ...
J. J. Gomez-Cadenas +7 more
core +3 more sources
Molecular Oncology, EarlyView.Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source
Discriminatory fees, coordination and investment in shared ATM networks [PDF]
This paper empirically examines the effects of discriminatory fees on ATM investment and welfare, and considers the role of coordination in ATM investment between banks.
Stijn Ferrari
core
Ataxia-telangiectasia Mutated (ATM)-dependent Activation of ATR Occurs through Phosphorylation of TopBP1 by ATM [PDF]
, 2007 ATM (ataxia-telangiectasia mutated) is necessary for activation of Chk1 by ATR (ATM and Rad3-related) in response to double-stranded DNA breaks (DSBs) but not to DNA replication stress. TopBP1 has been identified as a direct activator of ATR.
Dunphy, William G. +4 more
core +3 more sources
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Energy savings using an adaptive base station-to-relay station switching paradigm [PDF]
, 2012 Applying a Base Station (BS) sleep approach during low traffic periods has recently been advocated as a strategy for reducing energy consumption in cellular networks. The complete switching off of certain BS however, can lead to coverage holes and severe
Alam, Atm Shafiul +3 more
core +1 more source
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
CHROMATIN STRUCTURE AND DNA DAMAGE RESPONSE
Паёми Сино, 2017 Genomic integrity is constantly exposed to the products of metabolic activities and environmental processes that can induce DNA damage. A well-organized network of signaling cascade, designated as DNA damage response (DDR), encompasses systems of damage ...
M.A. NORMATOVA
doaj +1 more source
On Deviations from Bimaximal Neutrino Mixing [PDF]
, 2004 The PMNS neutrino mixing matrix U_{PMNS} is in general a product of two unitary matrices U_{lep} and U_{\nu} arising from the diagonalization of the charged lepton and neutrino mass matrices, U_{PMNS} = U^{\dagger}_{lep} U_{\nu}. Assuming that U_{\nu} is
Aguilar-Saavedra +57 more
core +3 more sources