Results 121 to 130 of about 3,054,495 (336)

Measurement report: Characterization of the vertical distribution of airborne Pinus pollen in the atmosphere with lidar-derived profiles – a modeling case study in the region of Barcelona, NE Spain

, 2021
Michaël Sicard, Oriol Jorba, Jiang Ji Ho-Zhang, Rebeca Izquierdo, Concepción De Linares, Marta Alarcón, Adolfo Comerón, Jordina Belmonte   +7 more
openalex   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

Model atmospheres of chemically peculiar stars: Self-consistent empirical stratified model of HD24712

, 2009
High-resolution spectra of some chemically peculiar stars clearly demonstrate the presence of strong abundance gradients in their atmospheres. However, these inhomogeneities are usually ignored in the standard scheme of model atmosphere calculations ...
Alecian, Babel, Bard, Bard, Black, Blackwell, Blackwell, Blanco, Campos, D. Shulyak, Fleurier, Garz, Goncharsky, Hauck, Hauschildt, Hui-Bon-Hoa, Khan, Khan, Kochukhov, Kochukhov, Kochukhov, Kochukhov, Kochukhov, Kupka, L. Mashonkina, Lueftinger, Lundberg, Mashonkina, Mashonkina, Mashonkina, Mashonkina, Michaud, Nieuwenhuijzen, O. Kochukhov, Piskunov, Piskunov, Piskunov, Raassen, Ryabchikova, Ryabchikova, Ryabchikova, Ryabchikova, Rybicki, Rybicki, Seaton, Smith, Smith, Smith, Smith, Stepanov, T. Ryabchikova, Vogt, Warner, Weiss, Wolff   +54 more
core   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

THE ANALYSIS OF THE ADVERSE AND DANGEROUS PHENOMENA OF THE WEATHER IN THE TERRITORY OF THE STAVROPOL REGION

Современная наука и инновации, 2022
The analysis of the climate characteristics of the hazardous hydrometeorological weather events in the territory of the Stavropol territory was carried out.
Galina Khamzatovna Badakhova, Nelly Anatolievna Kravchenko, Olga Grigorievna Fabrikantova   +2 more
doaj  

Formation of stratospheric nitric acid by a hydrated ion cluster reaction: Implications for the effect of energetic particle precipitation on the middle atmosphere [PDF]

, 2012
Ole‐Kristian Kvissel, Yvan Orsolini, Frøde Stordal, I. S. A. Isaksen, M. L. Santee   +4 more
openalex   +1 more source

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

FEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini, Nicolò Antonelli, Gianluca Molla   +2 more
wiley   +1 more source

Indoleamine 2,3‐dioxygenase 1 inhibition reverses cancer‐associated fibroblast‐mediated immunosuppression in high‐grade serous ovarian cancer

FEBS Open Bio, EarlyView.
CAF‐mediated immunosuppression in ovarian cancer is driven by IDO1, reducing T‐cell function. Inhibiting IDO1 restores T‐cell proliferation and cytotoxicity, increases cancer cell apoptosis, and may help overcome CAF‐induced immune suppression in high‐grade serous ovarian cancer. Targeting IDO1 may improve antitumor immunity.
Hyewon Lee, Jung Yoon Ho, In Sun Hwang, Youn Jin Choi   +3 more
wiley   +1 more source

Solar Impact on Climate: Modeling the Coupling Between the Middle and the Lower Atmosphere [PDF]

, 2005
Solar variability influences the earth's atmosphere on different time scales. In particular, the impact of the 11-year solar cycle is of interest as it provides the major contribution to natural climate variability.
Langematz, Ulrike, Matthes, Katja
core