Results 51 to 60 of about 111,299 (362)

BMP antagonist CHRDL2 enhances the cancer stem‐cell phenotype and increases chemotherapy resistance in colorectal cancer

Molecular Oncology, EarlyView.
Overexpression of CHRDL2 in colon cancer cells makes them more stem‐like and resistant to chemo‐ and radiotherapy. CHRDL2‐high cells have upregulation of the WNT pathway, genes involved in the DNA damage response (DDR) pathway and epithelial‐to‐mesenchymal transition (EMT). This leads to quicker repair of damaged DNA and more cell migration.
Eloise Clarkson, Annabelle Lewis
wiley   +1 more source

MISSION PROFILE AND DESIGN CHALLENGES FOR MARS LANDING EXPLORATION [PDF]

The International Archives of the Photogrammetry, Remote Sensing and Spatial Information Sciences, 2017
An orbiter and a descent module will be delivered to Mars in the Chinese first Mars exploration mission. The descent module is composed of a landing platform and a rover.
J. Dong, Z. Sun, W. Rao, Y. Jia, L. Meng, C. Wang, B. Chen   +6 more
doaj   +1 more source

Olaparib synergy screen reveals Exemestane induces replication stress in triple‐negative breast cancer

Molecular Oncology, EarlyView.
Screening 166 FDA‐approved anticancer drugs identifies the aromatase inhibitor Exemestane as a synergistic partner of PARP inhibitor Olaparib in BRCA‐proficient triple‐negative breast cancer. Exemestane induces ROS‐mediated replication stress, enhancing DNA damage and apoptosis alongside Olaparib.
Nur Aininie Yusoh, Liping Su, Suet Lin Chia, Xiaohe Tian, Haslina Ahmad, Martin R. Gill   +5 more
wiley   +1 more source

Water ice clouds in a martian global climate model using data assimilation [PDF]

, 2011
The water cycle is one of the key seasonal cycles on Mars, and the radiative effects of water ice clouds have recently been shown to alter the thermal structure of the atmosphere.
Lewis, S. R., Mulholland, D. P., Patel, M. R., Steele, Liam   +3 more
core  

RKIP overexpression reduces lung adenocarcinoma aggressiveness and sensitizes cells to EGFR‐targeted therapies

Molecular Oncology, EarlyView.
RKIP, a metastasis suppressor protein, modulates key oncogenic pathways in lung adenocarcinoma. In silico analyses linked low RKIP expression to poor survival. Functional studies revealed RKIP overexpression reduces tumor aggressiveness and enhances sensitivity to EGFR‐targeted therapies, while its loss promotes resistance.
Ana Raquel‐Cunha, Joana Pinheiro, Rui F. Marques, Patrícia Fontão, Diana Cardoso‐Carneiro, Adriana Mendes, Izabela N. F. Gomes, Ana Carolina Laus, Renato J. da Silva‐Oliveira, Rui Manuel Reis, Olga Martinho   +10 more
wiley   +1 more source

Nitrogen Fixation at Paleo‐Mars in an Icy Atmosphere

Geophysical Research Letters
Recent findings of NO near Gale Crater on Mars have been explained by two pathways: formation of nitric acid (HNO3) in a warm climate or formation of peroxynitric acid (HO2NO2) in a cool climate.
Danica Adams, Armin Kleinböhl, King‐Fai Li, Franklin P. Mills, Run‐Lie Shia, Robin Wordsworth, Yuk L. Yung   +6 more
doaj   +1 more source

Mars 2000 [PDF]

, 2000
Twenty years after the Viking Mission, Mars is again being scrutinized in the light of a flood of information from spacecraft missions to Mars, the Hubble Space Telescope, and the SNC meteorites.
Albee, Arden L.
core   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Effects of the 2018 Martian Global Dust Storm on Boundary Positions in the Induced Magnetosphere

The Planetary Science Journal
Global dust storms at Mars have a significant impact on the atmosphere and ionosphere, but only recently has their impact on the magnetosphere been investigated.
Catherine E. Regan, Andrew J. Coates, Mark Lester, Anne Wellbrock, Geraint H. Jones, Beatriz Sánchez-Cano, Philippe Garnier, Louisa J. Preston, František Němec, Václav Linzmayer, Rudy A. Frahm, Mats Holmström   +11 more
doaj   +1 more source

Quantification of Carbonates, Oxychlorines, and Chlorine Generated by Heterogeneous Electrochemistry Induced by Martian Dust Activity

Geophysical Research Letters, 2023
Heterogeneous electrochemistry induced by Martian dust activity is an important type of atmosphere‐surface interaction that affects geochemical processes at the Martian surface and in the Martian atmosphere.
Alian Wang, Andrew W. Jackson, Neil C. Sturchio, Jen Houghton, Chuck Y. C. Yan, Kevin S. Olsen, Quincy H. K. Qu   +6 more
doaj   +1 more source