Results 61 to 70 of about 111,299 (362)

YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma

Molecular Oncology, EarlyView.
The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy, Samuel Hartzler, Paula A. Vargas Carranza, Shyaman Jayasundara, Madison E. Yates, Nimod D. Janson, Bozhi Liu, Annaleigh Benton, Majid Kazemian, Jason A. Hanna   +9 more
wiley   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Trace gas assimilation of Mars orbiter observations [PDF]

, 2012
Ozone, water vapour and argon are minor constituents in the Martian atmosphere, observations of which can be of use in constraining atmospheric dynamical and physical processes.
Holmes, J. A., Lewis, S. R., Patel, M. R.   +2 more
core  

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Spherical Wind Sensor for the Atmosphere of Mars [PDF]

IEEE Sensors Journal, 2016
A novel wind speed and direction sensor designed for the atmosphere of Mars is described. It is based on a spherical shell divided into four triangular sectors according to the central projection of tetrahedron onto the surface of the unit sphere. Each sector is individually controlled to be heated above the ambient temperature
Lukasz Kowalski, Maria Teresa Atienza, Sergi Gorreta, Vicente Jimenez, Manuel Dominguez-Pumar, Santiago Silvestre, Luis M. Castaner   +6 more
openaire   +4 more sources

A guide to reactive oxygen species in tumour hypoxia: measurement and therapeutic implications

Molecular Oncology, EarlyView.
Hypoxia reshapes tumour redox landscapes by altering compartmental ROS production (mitochondria, NOX, ER, peroxisomes). Accurate interpretation requires oxygen‐contextualised measurement (live biosensors, chemical probes, EPR, LC–MS) and awareness of artefacts (reoxygenation, probe specificity).
Lina Hacker, Elysia Sarsam, Stuart J. Conway, Ester M. Hammond   +3 more
wiley   +1 more source

Breeding vectors and predictability in the Oxford Mars GCM [PDF]

, 2003
A breeding vectors approach is used to study the intrinsic predictability of the Martian atmosphere using the Oxford Mars General Circulation Model (MGCM).
Lewis, S.R., Newman, C.E., Read, P.L.
core  

The Challenge of Atmospheric Data Assimilation on Mars [PDF]

Earth and Space Science, 2017
Data assimilation is carried out for the Martian atmosphere with the Mars Climate Sounder (MCS) retrievals of temperature, dust, and ice. It is performed for the period Ls = 180° to Ls = 320° of Mars Year 29 with the Local Ensemble Transform Kalman Filter scheme and the Laboratoire de Météorologie Dynamique (LMD) Mars Global Climate Model (GCM).
T. Navarro, F. Forget, E. Millour, S. J. Greybush, E. Kalnay, T. Miyoshi   +5 more
openaire   +4 more sources

The E3 ubiquitin ligase, RNF219, suppresses CNOT6L expression to exhibit antiproliferative activity

FEBS Open Bio, EarlyView.
We identified RNF219 as a CCR4‐NOT complex‐interacting E3 ubiquitin ligase that targets the CCR4‐NOT subunit CNOT6L for ubiquitination. RNF219 directly binds to the DUF3819 domain of CNOT1 through its putative α‐helix spanning amino acids 521–542. Our findings also suggest that antiproliferative activity of RNF219 is at least partially mediated by ...
Shou Soeda, Melissa Montrose, Akinori Takahashi, Risa Ishida, Sandrine Burriel, Nao Ohmine, Tohru Natsume, Shungo Adachi, Minsoo Kim, Tadashi Yamamoto   +9 more
wiley   +1 more source

Observation based climatology Martian atmospheric waves perturbation Datasets

Scientific Data, 2023
The Martian atmospheric waves perturbation Datasets (MAWPD) version 2.0 is the first observation-based climatology dataset of Martian atmospheric waves. It contains climatology-gridded temperature, gravity waves, and tides spanning the whole Martian year.
Jie Zhang, Qianqian Ji, Zheng Sheng, Mingyuan He, Yang He, Xinjie Zuo, Zefeng He, Zilin Qin, Gangyao Wu   +8 more
doaj   +1 more source