Results 61 to 70 of about 113,594 (358)
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
A Simple Subgrid‐Scale Model for Slope Winds on Mars
Earth and Space ScienceGlobal Climate Models (GCMs) are useful tools for simulating the dynamics of Mars atmosphere on a planetary scale. However their coarse resolution (∼100 km) does not allow to capture small‐scale phenomena such as slope winds which can occur over scales ...
T. Pierron +4 more
doaj +1 more source
Geophysical Research Letters, 2023 Heterogeneous electrochemistry induced by Martian dust activity is an important type of atmosphere‐surface interaction that affects geochemical processes at the Martian surface and in the Martian atmosphere.
Alian Wang +6 more
doaj +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Methane on Mars: Thermodynamic Equilibrium and Photochemical Calculations [PDF]
, 2010 The detection of methane (CH4) in the atmosphere of Mars by Mars Express and Earth-based spectroscopy is very surprising, very puzzling, and very intriguing. On Earth, about 90% of atmospheric ozone is produced by living systems.
Ewell, M., Levine, J. S., Summers, M. E.
core +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Water ice clouds in a martian global climate model using data assimilation [PDF]
, 2011 The water cycle is one of the key seasonal cycles on Mars, and the radiative effects of water ice clouds have recently been shown to alter the thermal structure of the atmosphere.
Lewis, S. R. +3 more
core
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
The upper atmosphere and ionosphere of Mars [PDF]
The topics discussed include the following: the dynamic atmosphere of Mars; possible similarities with Earth and Venus; the atmosphere and ionosphere of Mars; solar wind interactions; future approved missions; and possible future ...
Brace, Larry H.
core +1 more source