Results 91 to 100 of about 399,430 (333)
Revised Line Profile Function for Hydrogenic Species
Open Astronomy, 2012 Analytical series expansions for the hydrogenic spectral line profile functions are derived starting from the three single expressions, obtained by integrating twice the convolution of the Holtsmark, Lorentz and Doppler line profile functions.
Sapar A., Poolamäe R.
doaj +1 more source
Ambiances, 2018 The paper provides a conceptual framework for understanding collectively shared political agency in public space. By using a phenomenological approach, it explores the spaces of protest movements by deploying Elias Canetti’s perspective on crowds and ...
Simon Runkel
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Molecular Oncology, EarlyView.Genetic testing in epithelial ovarian cancer includes both germline and tumor‐testing. This approach often duplicates resources. The current prospective study assessed the feasibility of tumor‐first multigene testing by comparing tumor tissue with germline testing of peripheral blood using an 18‐gene NGS panel in 106 patients.
Elisabeth Spenard +12 more
wiley +1 more source
How atmospheres inform urban planning practice – insights from the Tempelhof airfield in Berlin
Ambiances, 2019 The fundamental subject matter of urban planning is urban space. However, this fact is rarely reflected in planning theory. Instead of dealing with the everyday use of urban space and its atmospheric perception, planning discourse is dominated by ...
Ulrike Mackrodt
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Molecular Oncology, EarlyView.CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir +12 more
wiley +1 more source
, 2014 Basic assumptions of the NLTE approximation in stellar atmospheres are summarized. The assumptions of thermodynamic equilibrium, local thermodynamic equilibrium (LTE), and non-LTE (NLTE) are compared.
Kubát, Jiří
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Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
Harvesting Atmospheres—Exploring Atmospheric Elements in Spatial Design
ArchitectureThe atmosphere of an interior space within an architectural built form can be defined by the interactions between the material and immaterial elements surrounding the inhabitant of a space, expressed through our own responding embodied experience.
Gillian Treacy
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Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source